2021
DOI: 10.1016/j.cub.2021.08.051
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Trans-inhibition of axon terminals underlies competition in the habenulo-interpeduncular pathway

Abstract: Survival of animals is dependent on the correct selection of an appropriate behavioral response to competing external stimuli. Theoretical models have been proposed and underlying mechanisms are emerging to explain how one circuit is selected among competing neural circuits. The evolutionarily conserved forebrain to midbrain habenulo-interpeduncular nucleus (Hb-IPN) pathway consists of cholinergic and non-cholinergic neurons, which mediate different aversive behaviors. Simultaneous calcium imaging of neuronal … Show more

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Cited by 11 publications
(1 citation statement)
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References 46 publications
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“…We found that different populations of NI neurons also target specific IPN compartments; rln3a neurons project mainly to the dIPN and gsc2 neurons predominantly innervate the vIPN along its midline neuropil. A study byZaupa et al (2021) demonstrates that axon terminals from cholinergic and noncholinergic dHb neurons, which innervate the vIPN and dIPN respectively, show distinct patterns of activity. Spontaneous calcium spikes in cholinergic dHb terminals at the vIPN coincide with transient decreases in calcium signaling in non-cholinergic dHb terminals at the dIPN.…”
mentioning
confidence: 99%
“…We found that different populations of NI neurons also target specific IPN compartments; rln3a neurons project mainly to the dIPN and gsc2 neurons predominantly innervate the vIPN along its midline neuropil. A study byZaupa et al (2021) demonstrates that axon terminals from cholinergic and noncholinergic dHb neurons, which innervate the vIPN and dIPN respectively, show distinct patterns of activity. Spontaneous calcium spikes in cholinergic dHb terminals at the vIPN coincide with transient decreases in calcium signaling in non-cholinergic dHb terminals at the dIPN.…”
mentioning
confidence: 99%