Trans-gender induction of hair follicles

Reynolds, Amanda J.; Lawrence, C.M.; Cserhalmi-Friedman, Peter B.; Christiano, Angela M.; Jahoda, Colin A.B.

doi:10.1038/46938

Cited by 227 publications

(172 citation statements)

References 9 publications

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“…However, follicle-derived HSC activity may be of particular relevance to the human condition. It is now well established that rodent hair follicles display immune privilege, and our work and that of others has indicated that this is true for human dermal sheath cells (Paus et al, 1999;Reynolds et al, 1999); such cells may therefore prove to be admirable donor cell types in stem-cell-based therapies. Further, the ability to readily access dermal cell populations by skin biopsy, rather than a potentially more invasive procedure required for other stem cell types may make them particularly appropriate as a source of autologous or allogeneic HSC activity.…”

Section: Discussionmentioning

confidence: 98%

Hair follicle dermal cells repopulate the mouse haematopoietic system

Lako

Armstrong

Cairns

et al. 2002

Journal of Cell Science

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154

108

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Skin and hair follicle stem cell biology is the focus of increasing interest, not least because the adult hair follicle has well defined dermal and epithelial populations that display distinct developmental properties. Recent evidence suggests that a number of adult cell populations have much broader stem cell capabilities than previously thought. To examine whether this applied to the hair follicle, and with a view to developing the follicle as a stem cell model system we investigated whether adult hair follicles were capable of demonstrating haematopoietic stem cell activity. To investigate haematopoietic activity in hair follicles we first used in vitro haematopoietic colony assays. This demonstrated that rodent hair follicle end bulbs as well as micro-dissected dermal papilla and dermal sheath cells actively produced cells of erythroid and myeloid lineages but that follicle epithelial cells did not. As a more stringent test, we then transplanted cultured dermal papilla or dermal sheath cells from transgenically marked donor mice into lethally irradiated recipient mice and observed multi-lineage haematopoietic reconstitution when assayed at intervals of up to one year. Colony assays from bone marrow of primary recipients revealed that over 70% of clonogenic precursors were derived from donor hair follicle cells. When bone marrow from primary mice was harvested and used to repopulate secondary myeloablated recipients, multi-lineage haematopoietic engraftment was observed. Our data show that dermal but not epidermal compartments of the adult hair follicle have much broader stem cell activities than previously described. Although the treatment for many forms of blood disorder, such as leukemia, often requires transplantation of haematopoietic stem cells (HSC),their availability can be rate limiting. Given its easy accessibility, our identification of the hair follicle as a source of extramedullary haematopoietic stem cell activity makes it an attractive potential source for blood stem cell therapeutics and highlights its value as a model system in adult stem cell biology.

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Section: Discussionmentioning

confidence: 98%

Hair follicle dermal cells repopulate the mouse haematopoietic system

Lako

Armstrong

Cairns

et al. 2002

Journal of Cell Science

Self Cite

154

108

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“…?). The long, curved arrow denotes the demonstrated capability of adult epidermal cells to form a new hair follicle in response to appropriate mesenchymal stimuli (46,47). B, bulge; E, epidermis; FP, follicular or dermal papilla; M, matrix keratinocytes; ORS, outer root sheath; S, hair shaft; SC, stem cells; SG, sebaceous gland; TA, transit amplifying cells.…”

Section: Markers For Epidermal Stem Cells: the Search Continuesmentioning

confidence: 99%

Epidermal stem cells: Properties, markers, and location

Lavker

Sun

2000

Proc. Natl. Acad. Sci. U.S.A.

348

261

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“…1f). The DS contains DP progenitor cells (3,10,11), which may play a pivotal role in controlling the dynamic structural changes in HFs during hair cycling (12). Furthermore, their hair matrix cells were LEF1 + (Fig.…”

Section: Resultsmentioning

confidence: 99%

Restorative effect of hair follicular dermal cells on injured human hair follicles in a mouse model

Yamao

Inamatsu

Okada

et al. 2015

Experimental Dermatology

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No model is available for examining whether in vivodamaged human hair follicles (hu-HFs) are rescued by transplanting cultured hu-HF dermal cells (dermal papilla and dermal sheath cells). Such a model might be valuable for examining whether in vivo-damaged hu-HFs such as miniaturized hu-HFs in androgenic alopecia are improvable by autotransplanting hu-HF dermal cells. In this study, we first developed mice with humanized skin composed of hu-keratinocytes and hudermal fibroblasts. Then, a 'humanized scalp model mouse' was generated by transplanting hu-scalp HFs into the humanized skin. To demonstrate the usability of the model, the lower halves of the hu-HFs in the model were amputated in situ, and cultured hu-HF dermal cells were injected around the amputated area. The results demonstrated that the transplanted cells contributed to the restoration of the damaged HFs. This model could be used to explore clinically effective technologies for hair restoration therapy by autologous cell transplantation.

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Trans-gender induction of hair follicles

Cited by 227 publications

References 9 publications

Hair follicle dermal cells repopulate the mouse haematopoietic system

Hair follicle dermal cells repopulate the mouse haematopoietic system

Epidermal stem cells: Properties, markers, and location

Restorative effect of hair follicular dermal cells on injured human hair follicles in a mouse model

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