Trans-ferulic acid ameliorates cisplatin-induced testicular damage via suppression of TLR4, P38-MAPK, and ERK1/2 signaling pathways

Hassanein, Emad H.M.; Abdel-Wahab, Basel A.; Ali, Fares E.M.; El-Ghafar, Omnia A M Abd; Kozman, Magy R.; Sharkawi, Souty M.Z.

doi:10.1007/s11356-021-13544-y

Cited by 21 publications

(16 citation statements)

References 82 publications

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“…A pretreatment with C. endivia L. and the isolated compounds restored the disorganized architecture of the testes to nearly normal, as indicated by the histopathology and Johnsen score and thereby significantly elevated the serum level of testosterone compared to MTX alone. Our results are in agreement with those of others who suggested the useful use of Cichorium intybus , another species of the same family as C. endivia L., in testicular injury [ 86 , 87 ] and with others who examined the protective effect of coumaric [ 88 ], vanillic [ 89 , 90 ], and ferulic acids [ 89 , 90 , 91 ] against testicular damage.…”

Section: Discussionsupporting

confidence: 93%

“…Vanillic acid also demonstrated an anti-inflammatory effect, which is in agreement with other studies indicating the same results [ 94 , 104 , 105 ]. Hu et al [ 104 ], Hassanein et al [ 91 ], and Kassab et al [ 95 ] reported the anti-inflammatory action of ferulic acid and this supports our results.…”

Section: Discussionsupporting

confidence: 92%

“…Moreover, other studies documented the improved oxidative status of male reproductive organs by C. intybus [ 86 , 87 ]. Coumaric [ 92 ], vanillic [ 89 , 90 , 93 , 94 ], and ferulic acids [ 89 , 91 , 95 , 96 ] are phenolic compounds which are widely dispersed in numerous plants and have been extensively investigated for their antioxidant property. In the same manner, C. endivia L. crude extract and the phenolic fraction demonstrated an anti-inflammatory action by decreasing NF-κB, IL-1 β , IL-6, and TNF-α.…”

Section: Discussionmentioning

confidence: 99%

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Potential Gonado-Protective Effect of Cichorium endivia and Its Major Phenolic Acids against Methotrexate-Induced Testicular Injury in Mice

et al. 2022

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Cichorium endivia L. (Asteraceae) is a wide edible plant that grows in the Mediterranean region. In this study, a phytochemical investigation of C. endivia L. ethanolic extract led to the isolation of stigmasterol (1), ursolic acid (2), β-amyrin (3), azelaic acid (4), vanillic acid (5), (6S, 7E)-6-hydroxy-4,7-megastigmadien-3,9-dione (S(+)-dehydrovomifoliol) (6), 4-hydroxy phenyl acetic acid (7), vomifoliol (8), ferulic acid (9), protocatechuic acid (10), kaempferol (11), p. coumaric acid (12), and luteolin (13). In addition, the total phenolic content as well as the in vitro antioxidant activity of C. endivia L. extract were estimated. Moreover, we inspected the potential gonado-protective effect of C. endivia crude extract, its phenolic fraction, and the isolated coumaric, vanillic, and ferulic acids against methotrexate (MTX)-induced testicular injury in mice. There were seven groups: normal control, MTX control, MTX + C. endivia crude extract, MTX + C. endivia phenolic fraction, MTX + isolated coumaric acid, MTX + isolated vanillic acid, and MTX + isolated ferulic acid. MTX was given by i.p. injection of a 20 mg/kg single dose. The crude extract and phenolic fraction were given with a dose of 100 mg/kg/day, whereas the compounds were given at a dose of 10 mg/kg/day. A histopathological examination was done. The testosterone level was detected in serum together with the testicular content of malondialdehyde (MDA), catalase (CAT), superoxide dismutase (SOD), interleukin 1β (IL-1β), IL-6, tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB), B-cell lymphoma 2 (Bcl-2), Bcl-2 associated x protein (Bax), p53, and miR-29a. C. endivia crude extract, the phenolic fraction, and the isolated compounds showed significant elevation in their levels of testosterone, CAT, SOD, Bcl-2 with a significant decrease in their levels of MDA, TNF-α, IL-1β, IL-6, NF-κB, Bax, P53, and miR-29a compared to those of the MTX control group. In conclusion, C. endivia mitigated MTX-induced germ cell toxicity via anti-inflammatory, antioxidant, and antiapoptotic effects.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

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Potential Gonado-Protective Effect of Cichorium endivia and Its Major Phenolic Acids against Methotrexate-Induced Testicular Injury in Mice

et al. 2022

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“…Intensive research demonstrated that the activation of the MAPKs signaling pathway might affect the development of acute kidney injury [ 25 ]. A wave of recent research projects has pointed out the abnormal phosphorylation of JNK, ERK, and P38 proteins in the kidney of AKI mice [ 26 ].…”

Section: Discussionmentioning

confidence: 99%

Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity

et al. 2021

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Prevention of acute kidney injury caused by drugs is still a clinical problem to be solved urgently. Astaxanthin (AST) and docosahexaenoic acid (DHA) are important marine-derived active ingredients, and they are reported to exhibit renal protective activity. It is noteworthy that the existing forms of AST in nature are mainly fatty acid-acylated AST monoesters and diesters, as well as unesterified AST, in which DHA is an esterified fatty acid. However, no reports focus on the different bioactivities of unesterified AST, monoesters and diesters, as well as the recombination of DHA and unesterified AST on nephrotoxicity. In the present study, vancomycin-treated mice were used to evaluate the effects of DHA-acylated AST monoesters, DHA-acylated AST diesters, unesterified AST, and the recombination of AST and DHA in alleviating nephrotoxicity by determining serum biochemical index, histopathological changes, and the enzyme activity related to oxidative stress. Results found that the intervention of DHA-acylated AST diesters significantly ameliorated kidney dysfunction by decreasing the levels of urea nitrogen and creatinine, alleviating pathological damage and oxidative stress compared to AST monoester, unesterified AST, and the recombination of AST and DHA. Further studies revealed that dietary DHA-acylated AST esters could inhibit the activation of the caspase cascade and MAPKs signaling pathway, and reduce the levels of pro-inflammatory cytokines. These findings indicated that the administration of DHA-acylated AST esters could alleviate vancomycin-induced nephrotoxicity, which represented a potentially novel candidate or therapeutic adjuvant for alleviating acute kidney injury.

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“…In the exogenous pathway of apoptosis, TNF production is caused by LPS, the ligand of TLR4. The binding of LPS and TLR4 leads to secretion of a large amount of immunomotor TNF-α, which activates the innate immune responses through the TLR4-NF-κB or p38 MAPK pathway, playing a kay role in the modulation of apoptosis and inflammation ( Hassanein et al, 2021 ). It has been reported that TNF-α is involved in apoptosis mechanism via specific cell surface receptor TNFR 1, inducing apoptosis through TRADD ( Gao et al, 2020b ).…”

Section: Tlr4 Signalingmentioning

confidence: 99%

Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway

Shen

Cheng

et al. 2022

Front. Bioeng. Biotechnol.

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The repair and motor functional recovery after spinal cord injury (SCI) has remained a clinical challenge. Injury-induced gliosis and inflammation lead to a physical barrier and an extremely inhibitory microenvironment, which in turn hinders the recovery of SCI. TLR4-NF-κB is a classic implant-related innate immunomodulation signaling pathway and part of numerous biomaterial-based treatment strategies for SCI. Numerous experimental studies have demonstrated that the regulation of TLR4-NF-κB signaling pathway plays an important role in the alleviation of inflammatory responses, the modulation of autophagy, apoptosis and ferroptosis, and the enhancement of anti-oxidative effect post-SCI. An increasing number of novel biomaterials have been fabricated as scaffolds and carriers, loaded with phytochemicals and drugs, to inhibit the progression of SCI through regulation of TLR4-NF-κB. This review summarizes the empirical strategies for the recovery after SCI through individual or composite biomaterials that mediate the TLR4-NF-κB signaling pathway.

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Trans-ferulic acid ameliorates cisplatin-induced testicular damage via suppression of TLR4, P38-MAPK, and ERK1/2 signaling pathways

Cited by 21 publications

References 82 publications

Potential Gonado-Protective Effect of Cichorium endivia and Its Major Phenolic Acids against Methotrexate-Induced Testicular Injury in Mice

Potential Gonado-Protective Effect of Cichorium endivia and Its Major Phenolic Acids against Methotrexate-Induced Testicular Injury in Mice

Docosahexaenoic Acid-Acylated Astaxanthin Esters Exhibit Superior Renal Protective Effect to Recombination of Astaxanthin with DHA via Alleviating Oxidative Stress Coupled with Apoptosis in Vancomycin-Treated Mice with Nephrotoxicity

Strategies for Biomaterial-Based Spinal Cord Injury Repair via the TLR4-NF-κB Signaling Pathway

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