Trans Fatty Acids: Effects on Eicosanoid Production

Sugano, Michihiro; Koga, Tetsuro; Yamato, Takako; Nonaka, Michiko; Gu, Jong Yan

doi:10.1159/000423578

Cited by 2 publications

(2 citation statements)

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“…JA fractionation was attempted under two fatty acid forms: fatty acid ethyl esters (FAEE) and free fatty acids (FFA). Beneficial properties reported for JA and XA are anti-inflammatory [33], anti-proliferative [34] and cholesterol lowering [35,36] activities, enhancement of memory [37][38][39], modulation of immune response [40], or supression of hypertension [41], amongst others. The authors used the same working conditions described above (170 bar and 333 K) and stationary phases, with similar flow rates (adjusted for each specific sample and stationary phase).…”

Section: Polyunsaturated Fatty Acids (Pufa)mentioning

confidence: 99%

Supercritical Fluid Chromatography as a Technique to Fractionate High-Valued Compounds from Lipids

Montañés¹,

Tallon²

2018

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Natural products are in high demand these days due to rising awareness among consumers. Healthy diets, especially those in emerging markets, growth in populations with nutritional deficiencies, and supporting government regulations provide high growth opportunities for these compounds. However, extraction of high-valued compounds from natural sources is not an easy task. Natural products are complex matrices, with relevant compounds present in small amounts and often mixed with other compounds of similar structures. Most of the applications are related to the pharmaceutical sector, but interest in food and natural products is growing fast. Lipid and carbohydrate extracts are examples of starting materials employed to purify these relevant compounds. At the same time supercritical fluid chromatography (SFC) is an emerging technique for preparative separation due to (1) use of supercritical fluids, commonly carbon dioxide, giving a large reduction in use of organic solvents; and (2) new hardware has been made commercially available recently that makes SFC a viable option. SFC fulfills high demands with respect to selectivity, versatility and sensibility. Fractionation or purification by SFC of high-valued compounds from natural sources is an interesting option, the relevance of which will increase in the future. This paper is a survey of trends and applications of SFC in the field of natural products purification.

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Section: Polyunsaturated Fatty Acids (Pufa)mentioning

confidence: 99%

Supercritical Fluid Chromatography as a Technique to Fractionate High-Valued Compounds from Lipids

Montañés¹,

Tallon²

2018

Separations

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“…One of the richest sources of JA is biota seed (Biota orientalis) a well-known source and a very popular component of traditional Chinese pharmacopeia [17]. A number of beneficial properties have been reported for conifer oils containing NMI PUFA including antiinflammatory [18], anti-proliferative and skin protective [19], cholesterol-lowering activity [20,21], suppression of hypertension [22], modulation of immune response [23], enhancement of memory [24][25][26], minimization of hepatic reperfusion injury [27], and anti-proliferative properties [28]. Approaches to JA isolation have included multistep thin layer argentation chromatography, urea inclusion and argentation liquid chromatography in combination with solid phase extraction chromatography, countercurrent chromatography or via chemical synthesis [6,8,[28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Isolation of Non‐methylene Interrupted or Acetylenic Fatty Acids from Seed Oils Using Semi‐preparative Supercritical Chromatography

Montañés

Tallon

Catchpole

2017

J Americ Oil Chem Soc

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Preparative scale supercritical fluid chromatography was used for isolating and purifying uncommon non‐methylene interrupted or acetylenic polyunsaturated fatty acids ethyl esters from seed oils. Fractionation of Biota orientalis seed oil ethyl esters was performed by supercritical fluid chromatography to obtain juniperonic acid [(5Z,11Z,14Z,17Z)‐eicosa‐5,11,14,17‐tetraenoic acid], a non‐methylene interrupted polyunsaturated fatty acid. Fractionation of sandalwood seed oil ethyl esters yielded ximenynic acid [(E)‐octadec‐11‐en‐9‐ynoic acid], an acetylenic polyunsaturated fatty acid. The effects of CO2 flow rate, column stationary phase and particle size were explored to optimize ximenynic and juniperonic ethyl ester recovery and purity from ethyl ester mixtures using online UV/Vis detection. Particle size, followed by the stationary phase, were found to be the most important parameters to achieving good separation. Under optimized conditions, ximenynic and juniperonic ethyl ester purities greater than 99 and 95%, respectively, were achieved in a one step process without co‐solvent. The isolation and recovery of juniperonic acid from biota seed oil free fatty acids was also attempted. Using free fatty acids as the feed material, the non‐methylene interrupted polyunsaturated sciadonic acid was also able to be separated from other compounds including juniperonic acid under some conditions, and gave an increase in concentration of more than 17 times.

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Trans Fatty Acids: Effects on Eicosanoid Production

Cited by 2 publications

References 0 publications

Supercritical Fluid Chromatography as a Technique to Fractionate High-Valued Compounds from Lipids

Supercritical Fluid Chromatography as a Technique to Fractionate High-Valued Compounds from Lipids

Isolation of Non‐methylene Interrupted or Acetylenic Fatty Acids from Seed Oils Using Semi‐preparative Supercritical Chromatography

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