Trans fatty acids and conjugated linoleic acids in the milk of urban women and nomadic Fulani of northern Nigeria

Glew, Robert H.; Herbein, J.H.; Moya, Monica H.; Valdez, Jessica M.; Obadofin, Michael O.; Wark, W.A.; VanderJagt, Dorothy J.

doi:10.1016/j.cca.2005.10.030

Cited by 16 publications

(20 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent study from Spain, Luna et al (2007) reported that human milk contains 0.12-0.15% total fatty acids as CLA, with rumenic acid being the major component. This is close to the 0.14-0.28% reported earlier for the USA (Jensen et al, 1998) and 0.22-0.54% for Russia (McGuire et al, 1997) but values are lower for Africa (< 0.1%) (Glew et al, 2006). Compared to human milk, infant formulas contain less CLA (McGuire et al, 1997), but no recent data are available.…”

Section: F Conjugated Linoleic Acid (Cla) Isomers In Infant Nutritionsupporting

confidence: 83%

Dietary trans fatty acids: from the mother’s diet to the infant

Chardigny

2012

Trans Fatty Acids in Human Nutrition

View full text Add to dashboard Cite

Section: F Conjugated Linoleic Acid (Cla) Isomers In Infant Nutritionsupporting

confidence: 83%

Dietary trans fatty acids: from the mother’s diet to the infant

Chardigny

2012

Trans Fatty Acids in Human Nutrition

View full text Add to dashboard Cite

“…Our recent study that included 41 lactating Fulani women in northern Nigeria (34) found that they produced a milk-fat that contained 7-10 times less vaccenic acid and total TFA than the milk of women in France and several other developed countries. Since the mammary gland uses fatty acids contained in plasma lipoproteins to synthesize milk-fat, it is reasonable to expect that nursing Fulani women whose bodies have a low TFA content would produce a milk that contains proportionately low amounts of TFAs.…”

Section: Discussionmentioning

confidence: 99%

Lipid Profiles and <i>trans</i> Fatty Acids in Serum Phospholipids of Semi-nomadic Fulani in Northern Nigeria

Glew

Chuang

Berry

et al. 2010

J Health Popul Nutr

View full text Add to dashboard Cite

The Fulani are semi-nomadic pastoralists of West Africa whose diet, culture, and economy are centred on cattle. Previous studies have shown that the Fulani of northern Nigeria derive 50% of their total calories from fat and 30% of their calories from milk, cheese, yogurt, and butter oil that contain significant amounts of trans fatty acids (TFAs), primarily vaccenic acid, which raise total serum cholesterol and low-density lipoproteincholesterol (LDL-C), and lower high-density lipoprotein-cholesterol (HDL-C). The study was conducted to know how the consumption of relatively large amounts of dairy products by adult Fulani affected the TFA content of their serum phospholipids. Blood samples were collected from 22 male and 29 female Fulani, aged 35-60 years, who were living in rural areas of Gombe state in northeastern Nigeria. The total serum phospholipid fraction was isolated, and its fatty acid composition was determined. Surprisingly, vaccenic acid was not detected, and three other TFAs-18:1-t6, 18:1-t9, and 18:2-t9,t12-together accounted for only 0.16% of the total fatty acid. The mean serum total cholesterol, LDL-C, and triglyceride concentrations of the subjects were within the normal range for populations in developed countries; however, at 32 mg/dL, the mean serum HDL-C concentration of the Fulani males was slightly below the lower limit of the reference range. No correlations were observed between the total TFA percentage or that of the three individual TFAs and any of the parameters of the serum lipid profile. These findings indicate that, with respect to TFAs at least, the fatty acid pattern of the serum phospholipids of Fulani pastoralists does not reflect the high TFA content of their traditional diet. Despite the consumption of rumenic acid-rich dairy products, for unknown reasons, the semi-nomadic Fulani manage to maintain a low level of TFAs in their blood and a relatively healthful serum lipid profile. While the mechanism that accounts for this disconnect between the consumption of TFAs by Fulani pastoralists and the proportion of TFAs in their serum phospholipids is obscure, possibilities include discrimination against rumenic acid during the process of triglyceride synthesis and chylomicron synthesis in the intestine and the preferential oxidation of TFAs by Fulani the people compared to other ethnic groups.

show abstract

“…There are no studies on the effects of CLA on neonatal fatty acid metabolism in humans, but it is known that CLA may moderately modify the body weight, and fat and lean mass of growing animals [4]. Human milk contains measurable quantities of total CLA and these concentrations vary significantly all over the world [5][6][7][8][9][10] and can be strongly influenced by the diet and CLA intake [11][12][13]. Despite the interest in CLA content in human milk, data in the literature are not abundant and, in general, are limited to evaluating the RA content, the predominant isomer, or the total CLA content.…”

Section: Introductionmentioning

confidence: 99%

Fatty acid and conjugated linoleic acid isomer profiles in human milk fat

Luna

Juárez

Fuente

2007

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

The fatty acid composition of 39 mature human milk samples from four Spanish women collected between 2 and 18 weeks during lactation was studied by gas chromatography. The conjugated linoleic acid (CLA) isomer profile was also determined by silver‐ion HPLC (Ag+‐HPLC) with three columns in series. The major fatty acid fraction in milk lipids throughout lactation was represented by the monounsaturated fatty acids, with oleic acid being the predominant compound (36–49% of total fatty acids). The saturated fatty acid fraction represented more than 35% of the total fatty acids, and polyunsaturated fatty acids ranged on average between 10 and 13%. Mean values of total CLA varied from 0.12 to 0.15% of total fatty acids. The complex mixture of CLA isomers was separated by Ag+‐HPLC. Rumenic acid (RA, cis‐9 trans‐11 C18:2) was the major isomer, representing more than 60% of total CLA. Trans‐9 trans‐11 and 7‐9 (cis‐trans + trans‐cis) C18:2 were the main CLA isomers after RA. Very small amounts of 8‐10 and 10‐12 C18:2 (cis‐trans + trans‐cis) isomers were detected, as were different proportions of cis‐11 trans‐13 and trans‐11 cis‐13 C18:2. Although most of the isomers were present in all samples, their concentrations varied considerably.

show abstract

Trans fatty acids and conjugated linoleic acids in the milk of urban women and nomadic Fulani of northern Nigeria

Cited by 16 publications

References 53 publications

Dietary trans fatty acids: from the mother’s diet to the infant

Dietary trans fatty acids: from the mother’s diet to the infant

Lipid Profiles and <i>trans</i> Fatty Acids in Serum Phospholipids of Semi-nomadic Fulani in Northern Nigeria

Fatty acid and conjugated linoleic acid isomer profiles in human milk fat

Contact Info

Product

Resources

About