Trans-chalcone induces death by autophagy mediated by p53 up-regulation and β-catenin down-regulation on human hepatocellular carcinoma HuH7.5 cell line

Siqueira, Elaine da Silva; Concato, Vírgínia Márcia; Tomiotto-Pellissier, Fernanda; Silva, Taylon Felipe; Bortoleti, Bruna Taciane da Silva; Gonçalves, Manoela Daiele; Costa, Idessânia Nazareth; Verri, Waldiceu A.; Pavanelli, Wander Rogério; Mantovani, Mário; Miranda-Sapla, Milena Menegazzo; Conchon‐Costa, Ivete

doi:10.1016/j.phymed.2020.153373

Cited by 18 publications

(11 citation statements)

References 21 publications

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“…Further mechanistic studies demonstrated that TChal could bind and degrade chromosome region maintenance 1 (CRM1), a nuclear export receptor involved in the active transport of tumor suppressors, and increase heat-shock protein 40 (HSP40) expression in U2OS osteosarcoma cells; the interaction of HSP40 with MDM2 blocked MDM2-mediated ubiquitination of p53, leading to the enhanced stability and activation of p53 [ 128 , 130 ]. Moreover, Siqueira et al reported that TChal could reestablish the p53 pathway and prevent the overexpression of Wnt/β-catenin tumor development, inducing autophagy-related cell death and decreasing the metastatic capacity of HCC HuH7.5 cells [ 131 ]. Seba et al reported that the chalcone derivative 4′-aminochalcone ( 48 ) inhibited the migration and invasion of osteosarcoma cells through the inhibition of extracellular matrix enzymatic degradation and the modulation of p53, regulating the epithelial-mesenchymal transition (EMT)-related genes [ 132 ].…”

Section: Representative Mechanisms Of Anticancer Action Of Chalconesmentioning

confidence: 99%

Chalcone Derivatives: Role in Anticancer Therapy

et al. 2021

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Chalcones (1,3-diaryl-2-propen-1-ones) are precursors for flavonoids and isoflavonoids, which are common simple chemical scaffolds found in many naturally occurring compounds. Many chalcone derivatives were also prepared due to their convenient synthesis. Chalcones as weandhetic analogues have attracted much interest due to their broad biological activities with clinical potentials against various diseases, particularly for antitumor activity. The chalcone family has demonstrated potential in vitro and in vivo activity against cancers via multiple mechanisms, including cell cycle disruption, autophagy regulation, apoptosis induction, and immunomodulatory and inflammatory mediators. It represents a promising strategy to develop chalcones as novel anticancer agents. In addition, the combination of chalcones and other therapies is expected to be an effective way to improve anticancer therapeutic efficacy. However, despite the encouraging results for their response to cancers observed in clinical studies, a full description of toxicity is required for their clinical use as safe drugs for the treatment of cancer. In this review, we will summarize the recent advances of the chalcone family as potential anticancer agents and the mechanisms of action. Besides, future applications and scope of the chalcone family toward the treatment and prevention of cancer are brought out.

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Section: Representative Mechanisms Of Anticancer Action Of Chalconesmentioning

confidence: 99%

Chalcone Derivatives: Role in Anticancer Therapy

et al. 2021

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“…260 Besides, the benefits of plant-derived, natural compounds is that they can inhibit β-catenin signaling to induce cytotoxicity against HCC cells, while they are safe and have no toxicity on normal cells or hematological profile. 116 A few experiments have evaluated synthetic small molecules as inhibitors of β-catenin signaling. C-82 is a small molecule and active form of PRI-724 that can induce cell cycle arrest at G0/G1 phase and prevents growth of HCC cells.…”

Section: Dovepressmentioning

confidence: 99%

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Paskeh

Mirzaei

Ashrafizadeh

et al. 2021

JHC

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“…In addition, chalcones capable of inducing autophagy include hydroxysafflor yellow A [ 143 ], cardamonin [ 105 ], panduratin A [ 163 ], bavachalcone (isolated from Cullen corylifolium) [ 111 ], trans-chalcone [ 164 ], or α,2′-dihydroxy-4,4′-dimethoxydihydrochalcone, isolated from Cedrela odorata (Meliaceae) [ 165 ].…”

Section: Induction Of Cell Deathmentioning

confidence: 99%

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

Michalková¹,

Mirossay²,

Gazdova³

et al. 2021

Cancers

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Although great progress has been made in the treatment of cancer, the search for new promising molecules with antitumor activity is still one of the greatest challenges in the fight against cancer due to the increasing number of new cases each year. Chalcones (1,3-diphenyl-2-propen-1-one), the precursors of flavonoid synthesis in higher plants, possess a wide spectrum of biological activities including antimicrobial, anti-inflammatory, antioxidant, and anticancer. A plethora of molecular mechanisms of action have been documented, including induction of apoptosis, autophagy, or other types of cell death, cell cycle changes, and modulation of several signaling pathways associated with cell survival or death. In addition, blockade of several steps of angiogenesis and proteasome inhibition has also been documented. This review summarizes the basic molecular mechanisms related to the antiproliferative effects of chalcones, focusing on research articles from the years January 2015–February 2021.

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Trans-chalcone induces death by autophagy mediated by p53 up-regulation and β-catenin down-regulation on human hepatocellular carcinoma HuH7.5 cell line

Cited by 18 publications

References 21 publications

Chalcone Derivatives: Role in Anticancer Therapy

Chalcone Derivatives: Role in Anticancer Therapy

Wnt/β-Catenin Signaling as a Driver of Hepatocellular Carcinoma Progression: An Emphasis on Molecular Pathways

Molecular Mechanisms of Antiproliferative Effects of Natural Chalcones

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