Trans-chalcone added in topical formulation inhibits skin inflammation and oxidative stress in a model of ultraviolet B radiation skin damage in hairless mice

Topical emulsion containing pyrrolidine dithiocarbamate: effectiveness against ultraviolet B irradiation-induced injury of hairless mouse skin

“…Mice were randomly designed to different groups with five mice each: non‐irradiated control, irradiated control, irradiated and treated with control emulsion without PDTC (CTRLE), irradiated and treated with the EcPDTC. Mice received treatment with 0.5 g of the emulsions (EcPDTC or CTRLE) on the dorsal surface skin (application area of 11 cm 2 ) 12 h, 6 h and 5 min before and 6 h after the irradiation beginning session …”

“…Mice received treatment with 0.5 g of the emulsions (EcPDTC or CTRLE) on the dorsal surface skin (application area of 11 cm 2 ) 12 h, 6 h and 5 min before and 6 h after the irradiation beginning session. [11]…”

“…The oxidative stress and the level of DNA photodamage are major determinant of sunburn cell induction, identified as keratinocytes undergoing apoptosis . In this context, the utilization of anti‐inflammatory and antioxidant molecules can suppress interleukins and ROS production, thus preventing photoinactivation of antioxidant enzymes, LPO and induction of oxidative‐generated DNA damage after UVB irradiation exposure . UVB irradiation also triggers neutrophils and keratinocytes to produce matrix metalloproteinase‐9 (MMP‐9), which correlates with inflammatory skin diseases, accelerates photoageing and increases the metastatic potential of cancer cells .…”

“…[10] In this context, the utilization of anti-inflammatory and antioxidant molecules can suppress interleukins and ROS production, thus preventing photoinactivation of antioxidant enzymes, LPO and induction of oxidative-generated DNA damage after UVB irradiation exposure. [8,[11][12][13][14][15] UVB irradiation also triggers neutrophils and keratinocytes to produce matrix metalloproteinase-9 (MMP-9), which correlates with inflammatory skin diseases, accelerates photoageing and increases the metastatic potential of cancer cells. [16,17] Therefore, strategies targeting the biological alterations induced by UVB irradiation in the skin are promising therapeutic approaches.…”

Therapeutic Potential of Flavonoids in Pain and Inflammation: Mechanisms of Action, Pre-Clinical and Clinical Data, and Pharmaceutical Development

“…Topical formulations of flavonoids are a promising therapeutic option to provide a site-specific application of the drug with important pharmaceutical uses [261]. Several studies demonstrated that topical formulations containing quercetin, trans-chalcone, naringenin, and hesperidin methyl chalcone inhibit the UVB irradiation-induced inflammation and stress oxidative [50,61,72,263]. Therefore, their topical use may provide the required photochemical protection in addition to human sunscreens.…”