Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) inhibits the effect of androgens on the rat prostate

Saito, Taiichi; Nohno, Tsutomu; Yoshida, Hiroaki; Yokoya, Hisashi

doi:10.1007/bf01960405

Cited by 6 publications

(2 citation statements)

References 8 publications

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“…Administration of 100 mg of ferulic acid to Holstein heifers did not influence serum concentrations of LH or thyroid hormones, and only slightly but not significantly elevated GH (6). When given to rats, ferulic acid produced antiandrogenic activity on the prostate but not the testis (18). t "…”

Section: Metabolic and Endocrine Effectsmentioning

confidence: 92%

Gamma Oryzanol–Plant Sterol Supplementation: Metabolic, Endocrine, and Physiologic Effects

Wheeler

Garleb

1991

International Journal of Sport Nutrition

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The use of gamma-oryzanol and phytosterols is gaining popularity among various athletic populations. These compounds are being consumed in the belief that they elicit anabolic effects ranging from increased testosterone production and release to stimulating human growth hormone release. However, published scientific studies suggest that these compounds are poorly absorbed. Furthermore, animal studies indicate that when these compounds are injected subcutaneously or intravenously, they induce antianabolic or catabolic activity. Normally, less than 5% of orally consumed phytosterols are absorbed from the Intestinal tract, with the majority being excreted in the feces. Intravenous or subcutaneous injections of gamma-oryzanol in rats have been shown to suppress luteinizing hormone release, reduce growth hormone synthesis and release, and increase release of the catecholamines, dopamine and norepinephrine, in the brain. Although it hasn't been directly measured, this metabolic milieu, if accurate, may actually reduce testosterone production.

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Section: Metabolic and Endocrine Effectsmentioning

confidence: 92%

Gamma Oryzanol–Plant Sterol Supplementation: Metabolic, Endocrine, and Physiologic Effects

Wheeler

Garleb

1991

International Journal of Sport Nutrition

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“…Therefore, tocopherols were selected for further study to determine their effect on SRD5A isozyme expression and for a molecular docking study. In addition, other bioactive compounds in rice bran extracts, such as ferulic acid [67], phytic acid [68], oleic acid [27,69], linoleic acid [27,69,70], γ-linolenic acid [69,71], and γ-oryzanol [28], which are involved in androgen metabolism pathways, were compared to tocopherols and standard controls (finasteride and dutasteride).…”

Section: Extraction Yield and Bioactive Compoundsmentioning

confidence: 99%

Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

Khantham

Yooin

Sringarm

et al. 2021

Biology

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Steroid 5-alpha reductases (SRD5As) are responsible for the conversion of testosterone to dihydrotestosterone, a potent androgen, which is the aetiologic factor of androgenetic alopecia. This study aimed to compare the SRD5A gene expression suppression activity exerted by Thai rice bran extracts and their components and investigate the interactional mechanism between bioactive compounds and SRD5A2 using molecular dynamics (MD) simulation. Bran of Oryza sativa cv. Tubtim Chumphae (TRB), Yamuechaebia Morchor (YRB), Riceberry (RRB), and Malinil Surin (MRB), all rice milling by-products, was solvent-extracted. The ethanolic extract of TRB had the highest sum of overall bioactive compounds (γ-oryzanol; α-, β-, and γ-tocopherol; phenolics; and flavonoids). Among all extracts, TRB greatly downregulated the expression of SRD5A1, SRD5A2, and SRD5A3; there were no significant differences between TRB and finasteride regarding SRD5A suppression. The linear relationship and principal component analysis supported that the α-tocopherol content was correlated with the SRD5A suppression exerted by TRB. Furthermore, MD simulation demonstrated that α-tocopherol had the highest binding affinity towards SRD5A2 by interacting with residues Phe118 and Trp201. Our findings indicate that α-tocopherol effectively downregulates the expression of SRD5A genes and inhibits SRD5A2 activity, actions that are comparable to standard finasteride. TRB, a source of α-tocopherol, could be developed as an anti-hair loss product.

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A chemical classification of nonsteroidal antagonists of sex-steroid hormone action

Miquel

Gilbert

1988

Journal of Steroid Biochemistry

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Trans-4-hydroxy-3-methoxycinnamic acid (ferulic acid) inhibits the effect of androgens on the rat prostate

Cited by 6 publications

References 8 publications

Gamma Oryzanol–Plant Sterol Supplementation: Metabolic, Endocrine, and Physiologic Effects

Gamma Oryzanol–Plant Sterol Supplementation: Metabolic, Endocrine, and Physiologic Effects

Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

A chemical classification of nonsteroidal antagonists of sex-steroid hormone action

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