1999
DOI: 10.1016/s0957-4166(99)00244-x
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trans-3,4-Disubstituted pyrrolidines by 1,3-dipolar cycloaddition: enantioselective approaches and their limitations

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Cited by 34 publications
(13 citation statements)
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“…In some cases we have observed selectivity of up to 5 to 1 in this addition. 28 The stereochemistry at the -carbon was determined by Xray of 53. Since there was interest in screening both diastereomers, the conditions were altered in such way that a $ 1:1 mixture could be obtained.…”
Section: Entries 18mentioning
confidence: 99%
“…In some cases we have observed selectivity of up to 5 to 1 in this addition. 28 The stereochemistry at the -carbon was determined by Xray of 53. Since there was interest in screening both diastereomers, the conditions were altered in such way that a $ 1:1 mixture could be obtained.…”
Section: Entries 18mentioning
confidence: 99%
“…) 1 H NMR (500 MHz, DMSO-d6) δ 9,66 (s, 1H), 6,91 (s, 2H), 6,83 (s, 2H), 3,71 (s, 6H), 3,61 (s, 3H), 3,57 (s, 1H), 2,31 (s, 6H), 2,18 (s, 3H), 1,67 (s, 3H), 1,40 (s, 9H); 13 C NMR (126 MHz, DMSO-d6) δ 175,9, 165,2, 164,3, 152,5, 138,9, 135,9, 134,4, 133,9, 132,1, 128,8, 99,2, 82,5, 60,1, 55,8, 48,7, 43,5, 27,6, 20,6, 20, ), 3,99 (q, J = 7,1 Hz, 2H), 3,92 (qt, J = 6,7, 3,3 Hz, 2H), 3,77 (s, 3H), 3,75 (s, 3H), 1,58 (s, 3H), 1,53 (s, 3H), 1,42 (s, 3H), 1,37 (s, 3H); 13 C NMR (126 MHz, DMSO-d6) δ diasztereomer keverék : 172,4, 172,3, 168,1, 167,3, 167,3, 167,2, 159,2, 159,1, 139,2, 139,2, 136,2, 135,1, 129,8, 129,7, 128,3, 128,2, 127,6, 127,5, 126,9, 126,8, 120,6, 120,0, 119,2, 118,0, 113,0, 112,5, 61,8, 61,3, 55,3, 55,3, 50,6, 49,7, 42,5, 42,5, 15,7, 14,1, 13,8, 13 1H), 1,49 (s, 3H), 1,30 (s, 9H), 0,95 (t, J = 6,9 Hz, 3H); 13 C NMR (126 MHz, DMSO-d6) δ 172,1,166,6,166,3,136,8,134,5,131,9,129,5,128,3,128,1,127,9,126,7,61,5,52,5,52,4,51,2,35,2,28,4,…”
Section: (±)-Terc-butil-transz-3-metil-3-((345-trimetoxifenil)-karbamoil)-1-(246trimetilbenzoil)-aziridin-2-karboxilát ((±)-281{32}mentioning
confidence: 99%
“…) 1 H NMR (500 MHz, DMSO-d6) δ 7,99 (d, J = 7,1 Hz, 2H), 7,63 (t, J = 7,4 Hz, 1H), 7,51 (t, J = 7,9 Hz, 2H), 7,35 (d, J = 7,5 Hz, 2H), 7,27 -7,22 (m, 2H), 7,22 -7,15 (m, 1H), 7,08 (s, 1H), 3,88 -3,74 (m, 2H), 3,28 -3,10 (m, 2H), 1,42 (s, 3H), 1,23 (d, J = 2,7 Hz, 9H), 0,82 (t, J = 7,2 Hz, 3H); 13 C NMR (126 MHz, DMSO-d6) δ 172,6,166,8,166,2,135,9,133,8,133,1,129,5,128,7,128,4,127,9,126,6,61,0,53,2,50,9,50,6,33,9,28,1,14,8,13 13 C NMR (126 MHz, DMSO-d6) δ 177,4,164,6,138,1,134,4,133,…”
Section: (±)-Etil-cisz-1-benzoil-2-benzil-3-(terc-butilkarbamoil)-3-metilaziridin-2-karboxilát ((±)-282{36}mentioning
confidence: 99%
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