Tranexamic acid suppresses ultraviolet B eye irradiation‐induced melanocyte activation by decreasing the levels of prohormone convertase 2 and alpha‐melanocyte‐stimulating hormone

Hiramoto, Keiichi; Yamate, Yurika; Sugiyama, Daijiro; Takahashi, Yumi; Mafune, Eiichi

doi:10.1111/phpp.12131

Cited by 24 publications

(24 citation statements)

References 17 publications

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“…However, the pathways of the activation are distinct, although overlapping as discussed previously . Specifically, in Hiramoto's studies, UV conveys signals through the retina and UV‐sensing ganglionic cells , whereas (in our studies) increases in plasma levels of ACTH or α ‐MSH and β ‐END (present study) are secondary to the signals exclusively transmitted from the skin (eyes were covered).…”

Section: Discussionsupporting

confidence: 66%

Ultraviolet B stimulates proopiomelanocortin signalling in the arcuate nucleus of the hypothalamus in mice

Skobowiat

Slominski

2016

Experimental Dermatology

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We previously found that ultraviolet B (UVB) could stimulate the paraventricular nucleus (PVN) with activation the systemic hypothalamic–pituitary- adrenal (HPA) axis. To investigate whether UVB can also stimulate other hypothalamic nuclei, we tested its effect on the proopiomelanocortin (POMC) related signalling system in the arcuate nucleus (ARC) of female C57BL/6 and FVB albino mice. The shaved back skin of the mice was irradiated with either 100 or 400 mJ/cm2 of UVB. After 1, 3, 6 and 12 h, blood and hypothalamus were collected and processed for gene and protein expression, and measurement of α-MSH and β-endorphin (β-END) levels. An in situ immunohistochemical examination was performed for melanocortin receptor 4 (MC4R) and POMC-derived α-MSH. The expression of Pomc and MC4R mRNAs was stimulated, whereas that of AgRP was inhibited after exposure to UVB. It was accompanied by an increased number of both α-MSH- and MC4R-immunoreactive neurons in the ARC, and by increased levels of α-MSH and β-END (both found in the hypothalamus and plasma). This surprising discovery of UVB stimulating the POMC system in the ARC, accompanied by the increased plasma levels of α-MSH and β-END, paves the way for exciting areas of research on the communication between the skin and the brain, as well as is suggesting a new role for UVB in regulation of body metabolism.

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Section: Discussionsupporting

confidence: 66%

Ultraviolet B stimulates proopiomelanocortin signalling in the arcuate nucleus of the hypothalamus in mice

Skobowiat

Slominski

2016

Experimental Dermatology

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“…As a result of blocking the combination of plasminogen and plasmin from reaching the melanocytes, tranexamic acid obstructs the disengagement and activation of a melanin generation promotion factor by plasmin, and suppresses the pigmentation, for example, the conversion of the activity of a phospholipase A2 precursor , altering the processing from POMC to α‐MSH , and the disengagement of basic fibroblast growth factor . Moreover, in our recent report, it became clear that tranexamic acid obstructed PC2, which performs the processing of α‐MSH from the POMC of a pituitary gland by UVB eye irradiation . However, there are no reports of sex difference.…”

Section: Discussionmentioning

confidence: 99%

The gender differences in the inhibitory action of UVB‐induced melanocyte activation by the administration of tranexamic acid

Hiramoto

Yamate

Sugiyama

et al. 2016

Photoderm Photoimm Photomed

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“…We filtered out other wavelengths using Kodaul cellulose film (Eastmann Kodak Co., Rochester, NY, USA). This dose was based on that used in our previous study and the typical 1-h daytime doses received by humans in Osaka, Japan [14]. …”

Section: Methodsmentioning

confidence: 99%

The Preventive Effect of Coffee Compounds on Dermatitis and Epidermal Pigmentation after Ultraviolet Irradiation in Mice

Yamate

Hiramoto²,

Sato³

2017

Skin Pharmacol Physiol

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Background: Ultraviolet (UV) irradiation is well known to promote inflammation and pigmentation of skin. UVB mainly affects dermatitis and pigmentation. Coffee contains a number of polyphenols, such as caffeic acid (CA) and chlorogenic acid (CGA) but their in vivo bioactivity for photobiology remains unclear. Methods: C57BL/6j male mice were irradiated with UVB (1.0 kJ/m²/day) for 3 days. Five days after the final session of UVB irradiation, the dorsal skin, ear epidermis, and blood samples were analyzed to investigate the inflammatory factors, melanogenesis factors and related hormones. Results: After the oral administration of CA (100 mg/day) or CGA (100 mg/day) for 8 days, only CA was found to inhibit dermatitis and pigmentation. The pathway by which CA inhibits dermatitis is related to the mitogen-activated protein kinase (MAPK)/extracellular signal regulated kinase (ERK)1/2/cAMP response element binding protein (CREB) pathway. Otherwise, the pathway by which CA inhibits pigmentation is related to the activation of the β-endorphin-μ-opioid receptor and suppresses the cAMP-microphthalmia-associated transcription factor (MITF) pathway. Conclusion: It is suggested that the oral administration of CA prevented dermatitis and pigmentation after UVB irradiation in mice.

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Tranexamic acid suppresses ultraviolet B eye irradiation‐induced melanocyte activation by decreasing the levels of prohormone convertase 2 and alpha‐melanocyte‐stimulating hormone

Abstract: These results clearly indicate that tranexamic acid decreases the expression of PC2, which cleavages from proopiomelanocortin to α-MSH in the pituitary gland, thereby suppressing melanocyte activation.

Cited by 24 publications

References 17 publications

Ultraviolet B stimulates proopiomelanocortin signalling in the arcuate nucleus of the hypothalamus in mice

Ultraviolet B stimulates proopiomelanocortin signalling in the arcuate nucleus of the hypothalamus in mice

The gender differences in the inhibitory action of UVB‐induced melanocyte activation by the administration of tranexamic acid

The Preventive Effect of Coffee Compounds on Dermatitis and Epidermal Pigmentation after Ultraviolet Irradiation in Mice

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