Tranexamic acid reduces blood loss after cementless total hip arthroplasty?prospective randomized study in 40 cases

Abstract

We investigated the effects of

Tranexamic acid reduces blood loss in cemented hip arthroplasty: A randomized, double-blind study of 39 patients with osteoarthritis

“…Although earlier studies have shown similar results, they have included patients with different diagnoses and the dosage and timing of medication have been different. There has been only one study on uncemented hip arthroplasty with similar results (Yamasaki et al 2004).…”

Tranexamic Acid for Hemostasis in the Surgical Treatment of Metastatic Tumors of the Spine

“…Metaanalysis 2 confirms efficacy in decreasing perioperative blood loss and transfusion requirements in arthroplasty, although it seems to behave differently at the hip than the knee. In total hip replacement, several studies [3][4][5][6] show no decrease in intraoperative blood loss, but decreased postoperative blood loss and decreased transfusion requirements are generally confirmed, although 1 study showed no benefit. 7 In total knee replacement, the literature is more extensive and consistent in confirming that even operative bleeding is consistently decreased.…”

Efectividad del ácido tranexámico en las pérdidas sanguíneas perioperatorias en la artroplastia de cadera: revisión sistemática de la literatura y metaanálisis

“…De los 16 estudios, ninguno fue triple ciego, 14 fueron doble enmascarado 16---27,30,31 , uno era enmascarado solo para los pacientes 28 , y en otro, el cegamiento fue incierto 29 (tabla 2). Tres estudios 28,29,31 utilizaron estrategias informáticas para realizar la asignación aleatoria, y otros 3 utilizaron sobres cerrados para el ocultamiento de la asignación 23,28,29 . En un estudio la asignación al azar fue realizada por una persona/farmacéutico/residente que no participó en el estudio o en el cuidado de los pacientes 26 (tabla 2).…”