Tranexamic Acid Reduces Allogenic Transfusion in Revision Hip Arthroplasty

Noordin, Shahryar; Waters, Terrence; Garbuz, Donald S.; Duncan, Clivе P.; Masri, Bassam A.

doi:10.1007/s11999-010-1441-2

Cited by 46 publications

(21 citation statements)

References 24 publications

(23 reference statements)

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“…The TXA doses used in this study were the following: no‐IVTA group, 2 g topical; IVTA‐I and IVTA‐II groups, 2 g topical and 1 g IV; and TITA group, 3 g topical and 1 g IV (Tables and ). The TXA dose (4 g) used in the TITA group was higher than that in other studies (systemic dose range, 1‐3 g) . However, only 3 of the 4 g of TXA in the TITA group in this study was used topically.…”

Section: Discussionmentioning

confidence: 58%

Additional intraarticular tranexamic acid further reduced postoperative blood loss compared to intravenous and topical bathed tranexamic acid in total hip arthroplasty: a retrospective sequential series study

et al. 2016

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Section: Discussionmentioning

confidence: 58%

Additional intraarticular tranexamic acid further reduced postoperative blood loss compared to intravenous and topical bathed tranexamic acid in total hip arthroplasty: a retrospective sequential series study

et al. 2016

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“…14 Multiple prospective studies showed that tranexamic acid is effective in reducing blood loss and transfusion requirements in orthopedic patients undergoing hip and knee arthroplasty without an increased risk of thromboembolic disease. 1,8,[15][16][17] Furthermore, the medication is inexpensive and easy to administer around the time of surgery. 18 Although there has been no reported increased risk of cardiovascular complications after intravenous tranexamic acid administration, its use in high-risk patients undergoing total hip arthroplasty and total knee arthroplasty is controversial.…”

mentioning

confidence: 99%

Intravenous Tranexamic Acid Decreases Allogeneic Transfusion Requirements in Periacetabular Osteotomy

Bryan¹,

Sanders²,

Trousdale³

et al. 2016

Orthopedics

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Bernese (Ganz) periacetabular osteotomy is associated with significant blood loss and the need for perioperative transfusion. Tranexamic acid decreases blood loss and minimizes transfusion rates in total joint arthroplasty. However, no reports have described its use in patients undergoing Bernese periacetabular osteotomy. This study reports the use of intravenous tranexamic acid in these patients. The study included 137 patients (150 hips) who underwent isolated periacetabular osteotomy at a single institution between 2003 and 2014. Of these, 68 patients (75 hips) received intravenous tranexamic acid 1 g at the time of incision and 1 g at the time of closure. A group of 69 patients (75 hips) served as control subjects who underwent periacetabular osteotomy without administration of intravenous tranexamic acid. Thromboembolic disease was defined as deep venous thrombosis or pulmonary embolism occurring within 6 weeks of surgery. Outcomes measured included transfusion requirements, pre- and postoperative hemoglobin values, operative times, and thromboembolic disease rates. Aspirin was used as the thromboembolic prophylactic regimen in 95% of patients. The rate of allogeneic transfusion was 0 in the tranexamic acid group compared with 21% in the control group (P=.0001). No significant difference was found in the autologous cell salvage requirement (.96 vs 1.01; P=.43) or the thromboembolic disease rate between the tranexamic acid group and the control group (2.67% vs 1.33%; P=.31). The use of intravenous tranexamic acid led to a decreased transfusion requirement with no increased risk of thromboembolic disease in this contemporary cohort of patients undergoing periacetabular osteotomy.

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“…Chances are that CKD patients have poor surgical results [17] with the combination of their own medical problems [18,19], including infections, blood transfusions, medical complications, re-admissions and death rate, and their own diseases which have been reported as an independent risk factor. Generally, with lower levels of hemoglobin and a higher risk of blood loss, CKD patients take a higher risk of transfusions [20].…”

Section: Discussionmentioning

confidence: 99%

Hemostatic Effect of Tranexamic Acid on the Zhuang Nationality Patients with Chronic Kidney Disease in the Total Hip Arthroplasty

Huang

et al. 2020

Preprint

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Purpose The hemostatic effect of Tranexamic Acid (TXA) is analyzed in total hip total hip arthroplasty (THA) operated on chronic kidney disease (CKD) patients in Zhuang nationality. Methods A review of 53 Zhuang nationality patients with CKD who underwent unilateral total hip replacement at the People's Hospital of Guangxi Zhuang Autonomous Region from December 2012 to December 2019. They were divided into two groups: 28 patients in the TXA group and 25 patients in the non-TXA group. Nine aspects of comparison are operation time, blood loss during operation, postoperative drainage, changes of hemoglobin content before and after operation, prothrombin time before and after operation, recessive blood loss during operation, the number of patients with blood transfusion and that of thrombosis one month after operation. Results Two groups of CKD patients Compared, there was no statistically significant difference (p> 0.05) in the following aspects, namely, preoperative hemoglobin, preoperative and postoperative prothrombin time, preoperative and postoperative creatinine, preoperative and postoperative blood urea nitroge, while in the aspects of immediate postoperative hemoglobin, 24-hour postoperative hemoglobin, intraoperative bleeding, postoperative drainage and 24-hour occult blood loss, the number of patients with blood transfusion (4 in TXA group and 10 in non-TXA group), there was statistically significant difference (p< 0.05). Deep venous thrombosis of lower extremities was found in both groups of CKD patients after one month. No cases of complications or death were reported in the included patients. Conclusions In the THA, the use of TXA on CKD patients in Zhuang nationality can reduce dominant and recessive blood loss and decrease the incidence of lower extremity deep vein embolism.

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Tranexamic Acid Reduces Allogenic Transfusion in Revision Hip Arthroplasty

Cited by 46 publications

References 24 publications

Additional intraarticular tranexamic acid further reduced postoperative blood loss compared to intravenous and topical bathed tranexamic acid in total hip arthroplasty: a retrospective sequential series study

Additional intraarticular tranexamic acid further reduced postoperative blood loss compared to intravenous and topical bathed tranexamic acid in total hip arthroplasty: a retrospective sequential series study

Intravenous Tranexamic Acid Decreases Allogeneic Transfusion Requirements in Periacetabular Osteotomy

Hemostatic Effect of Tranexamic Acid on the Zhuang Nationality Patients with Chronic Kidney Disease in the Total Hip Arthroplasty

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