Tranexamic acid mouthwash — A prospective randomized study of a 2-day regimen vs 5-day regimen to prevent postoperative bleeding in anticoagulated patients requiring dental extractions

Carter, G.; Goss, AN

doi:10.1016/s0901-5027(03)90414-5

Cited by 53 publications

(61 citation statements)

References 13 publications

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“…Thirty‐eight studies (28–66) have been identified as clinical studies, examining the relationship between oral anticoagulants and dental treatment. Out of 38, 14 studies were RCTs (28–42). The results of one study have been published twice, once in 2006 (42) and once again in 2007 (41).…”

Section: Resultsmentioning

confidence: 99%

The dental patient on oral anticoagulant medication: a literature review

Kosyfaki

Strub

2010

Journal of Oral Rehabilitation

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Specific diseases and medications may considerably influence the delivery of oral care and the course of dental therapy. The purpose of this literature review is to examine the relationship between oral anticoagulant medication and dental treatment. Electronic and manual searches were conducted for clinical studies in the English literature for the years 1988-2010. The review process provided a total of 110 pertinent literature references, out of which 38 studies dealt with oral anticoagulants and dental treatment. Different treatment strategies relative to dental periprocedural anticoagulation regimens have been identified, and their accompanying thromboembolic and bleeding risks are being presented and discussed. Regarding to what extent a safe and successful dental treatment in patients on anticoagulant medication is feasible, the level of evidence is lacking. Until high-level data are provided, an individualised treatment approach after consultation with the physician of the patient is highly recommended.

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Section: Resultsmentioning

confidence: 99%

The dental patient on oral anticoagulant medication: a literature review

Kosyfaki

Strub

2010

Journal of Oral Rehabilitation

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“…In these studies, post-extraction bleeding cases were generally well-controlled using local hemostatic measures. Pre-operative tranexamic acid mouthwash was proven effective in several articles, and post-operative procedures such as sutures, local pressure, and gauze biting were also effective in the post-extraction bleeding control 3,11,12,28,30…”

Section: Reviewmentioning

confidence: 99%

Is stopping of anticoagulant therapy really required in a minor dental surgery? - How about in an endodontic microsurgery?

Cho

Kim

2013

Restor Dent Endod

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Nowadays, oral anticoagulants are commonly prescribed to numerous patients for preventing cardiovascular accident such as thromboembolism. An important side effect of anticoagulant is anti-hemostasis. In a major surgery, the oral anticoagulant therapy (OAT) regimen must be changed before the surgery for proper post-operative bleeding control. However, in a minor dental surgery and endodontic surgery, the necessity for changing or discontinuing the OAT is open to debate. In this study, risks of the consequences were weighed and analyzed. In patients who stop the OAT, the occurrence of thromboembolic complication is rare but the result is fatal. In patients who continuing the OAT, post-operative bleeding can be controlled well with the local hemostatic measures. In the endodontic surgery, there are almost no studies about this issue. The intra-operative bleeding control is particularly important in the endodontic surgery because of its delicate and sensitive procedures such as inspection of resected root surface using dental microscope and retrograde filling. Further studies are necessary about this issue in the viewpoint of endodontic surgery.

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“…During some dental procedures, it may be necessary to use hemostatic measures such as gauze compression, sutures, gelatin, or collagen sponges . Antifibrinolytic substances such as tranexamic acid, a synthetic derivative of the amino acid lysine, can be administrated . Patients must use mouthwash by rinsing with 4.8% concentration solution for 2 min four times daily, for 1 week …”

Section: Introductionmentioning

confidence: 99%

“…Antifibrinolytic substances such as tranexamic acid, a synthetic derivative of the amino acid lysine, can be administrated . Patients must use mouthwash by rinsing with 4.8% concentration solution for 2 min four times daily, for 1 week …”

Section: Introductionmentioning

confidence: 99%