Tranexamic Acid Is Effective in Decreasing Postoperative Bleeding and Transfusions in Primary Coronary Artery Bypass Operations

Abstract

In this randomized, placebo-controlled trial, we investigated the efficacy of tranexamic acid to decrease bleeding and blood transfusions after open-heart operations. Tranexamic acid administered before and during the operation was effective in decreasing both bleeding and transfusions. When tranexamic acid was administered immediately after the operation, it had a minor beneficial effect.

Thromboelastography-Based Transfusion Algorithm Reduces Blood Product Use after Elective CABG: A Prospective Randomized Study

“…Second, it has been accepted that the benefit of antifibrinolytic drugs as a blood conservation tool must begin prior to the start of fibrinolysis. However, in a randomized trial by Brown et al, 21 it has been shown that TA exerts similar antifibrinolytic action when administered before and during operation. Its effect remains minimal when applied after operation.…”

Preservation of collagen-induced whole blood platelet aggregation by tranexamic acid therapy in primary cardiac valve surgery

“…18 Brown et al reported tranexamic acid preserved platelet function as measured by thromboelastogram. 12 However, as to platelet aggregation, tranexamic acid was reported to have no effect on collagen-, ADP-or thrombin-induced platelet aggregation in platelet-rich-plasma (PRP). 18 Menzies et al also reported that tranexamic acid had no effect on platelet aggregation in PRP.…”

Plasma and cerebral spinal fluid tranexamic acid quantitation in cardiopulmonary bypass patients

“…Tranexamic acid is used to treat a variety of bleeding disorders, and to reduce postoperative blood loss in various types of surgery. Intravenously administered TXA decreases postoperative blood loss and blood transfusion requirements in patients undergoing CPB [2][3][4].…”