Tranexamic Acid in Patients with Green Snake Bite in Western Region of Nepal

Sapkota, Subash; Acharya, Ramesh Raj; Paudel, Naba R.

doi:10.3126/bjhs.v3i1.19739

Cited by 1 publication

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“…44 Hence, antifibrinolytic drugs have been used in the management of snakebite victims by some. 45,46…”

Section: Discussionmentioning

confidence: 99%

“…44 Hence, antifibrinolytic drugs have been used in the management of snakebite victims by some. 45,46 Microthrombi formed in DIC are shown to lead to end organ damage, as evidenced most commonly by acute tubular necrosis and renal failure. 47 The possibility of thrombotic microangiopathy in bite victims and impaired clearing of microthrombi in renal vasculature leading to renal failure is an argument against the use of antifibrinolytics such as TXA.…”

Section: Role Of Tranexamic Acid In Snakebitementioning

confidence: 99%

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Hematotoxic Snakebite Victim with Trauma: The Role of Guided Transfusion, Rotational Thromboelastometry, and Tranexamic Acid

Abraham

Hakkeem

Mathew

et al. 2020

Wilderness & Environmental Medicine

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Hematotoxic snake bite is a leading cause of mortality in South India. However, it is rare for the emergency physician to encounter a patient with trauma associated with snakebite. Management of such a patient differs substantially from the routine management of either a trauma patient or a snakebite victim. A 59-y-old man was bitten by a snake, after which he lost consciousness, fell, and sustained facial trauma. He was rushed to the emergency department within 30 min and was discovered to have ongoing oromaxillofacial bleeding. His respiratory distress and gasping respirations warranted orotracheal intubation and ventilation. He was treated with anti-snake venom and underwent viscoelastometry-guided transfusion to correct coagulopathy. Hemostasis was achieved after administration of tranexamic acid and bilateral posterior nasal packing. Imaging studies revealed craniomaxillofacial trauma with intracranial hemorrhage. He underwent a delayed mandibular repair. Judicious, guided fluid management, adequate nutrition, and prompt weaning off the ventilator allowed early discharge of the patient from the hospital. The minimal weakness present in his left lower limb at the time of discharge had improved by the time of follow-up. This report shows the utility of early and rapid anti-snake venom in envenomated victims with coagulopathy. The role of cryoprecipitate, tranexamic acid, and viscoelastometric testing needs further exploration in specific hematotoxic snakebites.

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“…44 Hence, antifibrinolytic drugs have been used in the management of snakebite victims by some. 45,46…”

Section: Discussionmentioning

confidence: 99%