Tranexamic Acid in Patients With Cancer Undergoing Endoprosthetic Reconstruction: A Retrospective Review

Abstract

Introduction: Endoprosthetic reconstruction presents a significant risk of perioperative blood loss. Tranexamic acid (TXA) is an antifibrinolytic agent used to reduce blood loss in orthopaedic procedures. The safety and efficacy of TXA in arthroplasty are well documented. There is, however, a dearth of literature exploring the safety and efficacy of TXA in musculoskeletal oncology patients. This retrospective, comparative study explores the effects of TXA on perioperative blood loss, blood transfusion rates, venous thromboembolism (VTE) occurrence, and hospital stay in patients undergoing resection of an aggressive bone tumor and endoprosthetic reconstruction. Methods: For the study, charts from a total of 90 patients who underwent resection of an aggressive bone tumor and endoprosthetic reconstruction were reviewed; of these patients, 34 were in the TXA group and 56 in the non-TXA group. Study participants composed of a heterogeneous group of patients with primary bone sarcoma and metastatic osseous disease. Patients in the TXA group received 1 g of topical TXA administered into the wound bed before closure. The Hemoglobin Balance method was used to calculate blood loss. Patients were followed for 6 weeks. Results: Patients undergoing proximal femur replacement and distal femur replacement in the TXA group experienced a 796 and 687 mL reduction in 72-hour mean blood loss, respectively (P = 0.0003 and P = 0.006). Average blood transfusions decreased by 0.45 U of packed red blood cells per patient in the TXA group (P = 0.048) and transfusion incidence decreased by 21.1% compared with the non-TXA group (P = 0.04). Patients undergoing proximal femur replacement in the TXA group left the hospital 2.2 days earlier than those in the non-TXA group (P = 0.0004). No increase in VTE rate was observed with TXA use. Discussion: This study found results similar to total joint arthroplasty with regard to TXA's effect on perioperative blood loss, transfusion rates, hospital stay, and VTE occurrence. It provides initial data to support the efficacy of topical TXA use in this patient cohort. Level of Evidence: Level III, retrospective cohort study

Use of tranexamic acid is not associated with complications following bipolar hemiarthroplasty for metastatic disease

“…Despite the efficacy of TXA in other applications of orthopedic surgery, 10,12,13,17,18 this study did not demonstrate a reduction in postoperative blood loss or transfusion requirement. In this study, blood loss was evaluated via the hemoglobin balance method.…”

Thromboembolism in Malignant Musculoskeletal Tumour: A Literature Review

“…Haase et al found that the usage of tranexamic acid in cancer patients undergoing endoprosthetic reconstruction decreased the number of patients with venous thromboembolism postoperatively. However, the result was statistically insignificant, and the main purpose of tranexamic acid is to decrease blood loss and not to decrease or change the risk of postoperative venous thromboembolism in musculoskeletal cancer patients [ 21 ]. Thromboprophylaxis is a new approach used to prevent the occurrence of postoperative venous thromboembolism, in which a pharmacologic agent is administrated in order to decrease the risk of thrombus formation.…”

Tranexamic acid in patients with current or former cancer undergoing hip and knee arthroplasty

“…In fact, few, if any, studies have been able to identify TXA as a risk factor for VTEs, regardless of patient population. 1,17,18,[21][22][23][24] For instance, Sabbag et al 17 others. The administration of a lysine analog during surgery was associated with significantly decreased transfusion risk and blood loss, while there was no increased risk of mortality, infection, or VTE.…”