Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery

doi:10.1056/nejmx180005

N Engl J Med

2018

DOI: 10.1056/nejmx180005

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Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery

Abstract: 1 found that the risk of death was not significantly higher with tranexamic acid than with placebo among patients undergoing cardiac surgery. This drug has a class IA indication for bleeding prophylaxis, decreasing the use of blood products and the risk of reintervention. Doses that are less than 50 mg per kilogram of body weight are effective in preventing bleeding as well as in decreasing the inflammatory response that is associated with cardiopulmonary bypass. 2Patients with the 5G/G genotype had a greater … Show more

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Cited by 2 publications

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tableone: An open source Python package for producing summary statistics for research papers

et al. 2018

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Objectives In quantitative research, understanding basic parameters of the study population is key for interpretation of the results. As a result, it is typical for the first table (“Table 1”) of a research paper to include summary statistics for the study data. Our objectives are 2-fold. First, we seek to provide a simple, reproducible method for providing summary statistics for research papers in the Python programming language. Second, we seek to use the package to improve the quality of summary statistics reported in research papers. Materials and Methods The tableone package is developed following good practice guidelines for scientific computing and all code is made available under a permissive MIT License. A testing framework runs on a continuous integration server, helping to maintain code stability. Issues are tracked openly and public contributions are encouraged. Results The tableone software package automatically compiles summary statistics into publishable formats such as CSV, HTML, and LaTeX. An executable Jupyter Notebook demonstrates application of the package to a subset of data from the MIMIC-III database. Tests such as Tukey’s rule for outlier detection and Hartigan’s Dip Test for modality are computed to highlight potential issues in summarizing the data. Discussion and Conclusion We present open source software for researchers to facilitate carrying out reproducible studies in Python, an increasingly popular language in scientific research. The toolkit is intended to mature over time with community feedback and input. Development of a common tool for summarizing data may help to promote good practice when used as a supplement to existing guidelines and recommendations. We encourage use of tableone alongside other methods of descriptive statistics and, in particular, visualization to ensure appropriate data handling. We also suggest seeking guidance from a statistician when using tableone for a research study, especially prior to submitting the study for publication.

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tableone: An open source Python package for producing summary statistics for research papers

et al. 2018

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A Systematic Review of Tranexamic Acid in Plastic Surgery: What’s New?

Scarafoni¹

2021

Plastic and Reconstructive Surgery - Global Open

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Background: Blood loss associated with surgical interventions can lead to several complications. Therefore, minimizing perioperative bleeding is critical to improve overall survival. Several interventions have been found to successfully reduce surgical bleeding, including the antifibrinolytic agent. After aprotinin was withdrawn from the market in 2008, TXA remained the most commonly used medication. The safety and efficacy of TXA has been well studied in other specialties. TXA has been rarely used in plastic surgery, except in craniofacial procedures. Since the last review, the number of articles examining the use of TXA has doubled; so the aim of this systematic review is to update the readers on the current knowledge and clinical recommendations regarding the efficacy of TXA in plastic surgical procedures. Methods: A systematic literature search was conducted in Medline, SciELO, Cochrane, and Google Scholar to evaluate all articles that discussed the use of TXA in plastic surgery in the fields of aesthetic surgery, burn care, and reconstructive microsurgery. Results: A total of 233 publications were identified using the search criteria defined above. After examination of titles and abstracts, and exclusion of duplicates, a total of 23 articles were selected for analysis. Conclusions: The literature shows a clear benefit of using TXA to decrease blood loss regardless of the administration route, with no risk of thrombosis events. Also, TXA elicits a potent anti-inflammatory response with a decrease in postoperative edema and ecchymosis, which improves recovery time. Further investigations are needed to standardize the optimal administration route and dosage of TXA.

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Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery

Cited by 2 publications

References 1 publication

tableone: An open source Python package for producing summary statistics for research papers

tableone: An open source Python package for producing summary statistics for research papers

A Systematic Review of Tranexamic Acid in Plastic Surgery: What’s New?

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