Tranexamic acid decreases blood loss in total shoulder arthroplasty and reverse total shoulder arthroplasty

Abildgaard, Jeffrey T.; McLemore, Ryan; Hattrup, Steven J.

doi:10.1016/j.jse.2016.02.002

Cited by 50 publications

(46 citation statements)

References 28 publications

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“…Finally, 4 studies meet eligibility criteria of the present meta-analysis—2 of them were RCTs [15,16] and 2 were non-RCTs. [17,18] Overall, the 4 studies included 250 patients in the tranexamic acid group and 234 patients in the control group.…”

Section: Resultsmentioning

confidence: 99%

“…Two studies applied general anesthesia [15,18] and others did not provide a detailed description. All studies [15–18] reported that surgical procedure was operated by the same team. Prophylactic anticoagulation therapy was performed as a routine in all included articles.…”

Section: Resultsmentioning

confidence: 99%

“…Four studies [15–18] reported the postoperative hemoglobin level after total shoulder arthroplasty. A random-effects model was used ( χ 2 = 9.64, df = 3, I 2 = 68.9%, P = .02).…”

Section: Resultsmentioning

confidence: 99%

“…[15–18] A random-effects model was used ( χ 2 = 3.13, df = 3, I 2 = 4.0%, P = .373). The present meta-analysis showed that there was significant difference between the tranexamic acid and control groups in terms of transfusion requirements (OR 0.34, 95% CI 0.13–0.91, P = .03, d = 0.29; Fig.…”

Section: Resultsmentioning

confidence: 99%

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Efficiency and safety of tranexamic acid in reducing blood loss in total shoulder arthroplasty

Sun

Zhang

et al. 2017

Medicine

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Objective:This meta-analysis aimed to evaluate the efficiency and safety of tranexamic acid for reducing blood loss and transfusion requirements in patients undergoing total shoulder arthroplasty.Methods:A systematic search was performed in Embase (1980–2017.04, embase.com), Medline (1966–2017.04, medline.com), PubMed (1966–2017.04, pubmed.com), ScienceDirect (1985–2017.04, sciencedirect.com), and Web of Science (1950–2017.04, webofknowledge.com). Study which assessed the efficiency and safety of tranexamic acid in total shoulder arthroplasty was selected. Meta-analysis was performed using Stata 11.0 software.Results:In all, 484 patients from 2 randomized controlled trials (RCTs) and 2 non-RCTs were subjected to meta-analysis. The present meta-analysis demonstrated that there was less total blood loss (mean difference [MD] −172.16, 95% confidence interval [CI] −35.46 to −308.87, P = .01, d = 0.33) and transfusion rate (odds ratio 0.34, 95% CI 0.13 to 0.91, P = .03, d = 0.29) in tranexamic acid groups compared with the control groups. There were no significant differences in duration of surgery (MD 0.02, 95% CI −0.12 to 0.22, P = .89, d = 0.19), length of stay (MD −0.06, 95% CI −0.26 to 0.14, P = .56, d = 0.20), or incidence of adverse effects such as deep venous thrombosis (odds ratio 1.15, 95% CI 0.33 to 4.00, P = .83, d = 0.53).Conclusion:Clinical application of tranexamic acid seemed to result in significant reductions in total blood loss, hemoglobin decline and transfusion requirements following total shoulder arthroplasty. Moreover, no increased risk of the thrombotic events was identified. Due to the limited quality of the evidence currently available, higher quality RCTs are required.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Four studies [15–18] reported the postoperative hemoglobin level after total shoulder arthroplasty. A random-effects model was used ( χ 2 = 9.64, df = 3, I 2 = 68.9%, P = .02).…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Efficiency and safety of tranexamic acid in reducing blood loss in total shoulder arthroplasty

Sun

Zhang

et al. 2017

Medicine

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“…However, the benefits of TXA administration have not been comprehensively investigated in RTSA. A few comparative studies have been conducted in Caucasian populations on the use of TXA for reducing blood loss after TSA and RTSA [ 16 – 18 ]. However, it is not still clear in Asians with RTSA.…”

Section: Introductionmentioning

confidence: 99%

Effect of Tranexamic Acid on Hematologic Values and Blood Loss in Reverse Total Shoulder Arthroplasty

Kim

Jung

Kim

et al. 2017

BioMed Research International

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.Purpose. Use of tranexamic acid (TXA) in the setting of arthroplasty of the lower extremity has been previously described. The aim of this study was to evaluate the benefit of a single dose of TXA (500 mg vial) administered intravenously just prior to RTSA in an Asian population. Methods. The records of 48 patients (no TXA, = 24, versus TXA, = 24) that underwent RTSA for cuff tear arthropathy were retrospectively reviewed. All patients had a Hemovac drain positioned for 2 days after surgery. Hemoglobin (Hb) and hematocrit (Hct) were checked on postoperative day 2 and compared with preoperative levels. Results. Hematologic change on postoperative day 2 as determined by Hb level after surgery was statistically lower in the TXA group (2.8 ± 0.8 versus 2.1 ± 0.8 (mg/dL), = 0.006). Mean fall in Hct level was also significantly less in the TXA group (8.0 ± 2.5 versus 6.1 ± 2.6 (L/L), = 0.012). Total Hemovac drainage tended to be lower in the TXA group (263.4 ± 129.3 versus 203.5 ± 84.2 (ml), = 0.064). TXA was found to have no noticeable side effects. Conclusion. The use of a single intravenous dose of TXA immediately prior to RTSA reduces hematologic deterioration postoperatively and the amount of Hemovac drainage. TXA could avoid unnecessary transfusion and its associated medical side effects and cost.

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Neurosurgical Considerations for the Obese Patient

Kundu,

Salazar

2024

Obesity

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Tranexamic acid decreases blood loss in total shoulder arthroplasty and reverse total shoulder arthroplasty

Cited by 50 publications

References 28 publications

Efficiency and safety of tranexamic acid in reducing blood loss in total shoulder arthroplasty

Efficiency and safety of tranexamic acid in reducing blood loss in total shoulder arthroplasty

Effect of Tranexamic Acid on Hematologic Values and Blood Loss in Reverse Total Shoulder Arthroplasty

Neurosurgical Considerations for the Obese Patient

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