Tranexamic acid (CyklokapronR)-induced fixed-drug eruption

Nicholas

Case Reports in Immunology

2016

Tranexamic acid (TXA) allergy is extremely rare. An 80-year-old woman without prior exposure to TXA underwent elective knee replacement. Shortly after induction of anaesthesia and intravenous TXA, she developed hypotension, tachycardia, and facial erythema accompanied by a raised serum tryptase. Later, skin prick and intradermal testing confirmed positive responses to TXA in high dilution and with negative results to the other drugs used. While neuromuscular blocking agents, opiates, and antibiotics remain the most frequent cause of anaphylaxis during anaesthesia, allergy to TXA should always be borne in mind and requires skin testing for confirmation as there are presently no blood tests available.

“…This was attributed to tranexamic acid and was unresponsive to graded introduction of TXA on 2 occasions, with rashes appearing with doses as low as 25 micrograms [6]. …”

Section: Discussionmentioning

confidence: 99%

Tranexamic Acid: An Exceedingly Rare Cause of Anaphylaxis during Anaesthesia

Nicholas

Case Reports in Immunology

2016

J of Cosmetic Dermatology

“…No mutagenic activity or harmful fetal effects have been reported . Adverse events that have been reported include anaphylactic shock, skin reaction, and acute renal cortical necrosis . TA has no effect on coagulation parameters.…”

Section: Properties Of Ta and Its Safety Profilementioning

confidence: 99%

Tranexamic acid: an important adjuvant in the treatment of melasma

Tse¹,

Hui²

2013

123

125

“…To date, fixed drug eruption caused by tranexamic acid is rarely reported in English literatures. [ 1 ] Fixed drug eruption appears as solitary or multiple well-circumscribed, rounded erythematous macules. The pathogenesis of fixed drug eruption is not fully elucidated as yet; however, the resting lesions of previously affected sites contain a number of CD8-positive T cells in the basal layers of the epidermis, which play a major role in the epidermal injury via interferon-γ (IFN-γ).…”

Section: Discussionmentioning

confidence: 99%

Tranexamic acid-induced fixed drug eruption

2015

A 33-year-old male showed multiple pigmented patches on his trunk and extremities after he took tranexamic acid for common cold. He stated that similar eruptions appeared when he was treated with tranexamic acid for influenza 10 months before. Patch test showed positive results at 48 h and 72 h by 1% and 10% tranexamic acid at the lesional skin only. To our knowledge, nine cases of fixed drug eruption induced by tranexamic acid have been reported in Japan. Tranexamic acid is a safe drug and frequently used because of its anti-fibrinolytic and anti-inflammatory effects, but caution of inducing fixed drug eruption should be necessary.