Tranexamic Acid Causes Chondral Injury Through Chondrocytes Apoptosis Induced by Activating Endoplasmic Reticulum Stress

Wang, Jiahao; Liang, Shuailong; Ma, Tianliang; Chen, Sijie; Hu, Yihe; Wang, Long

doi:10.1016/j.arthro.2023.08.019

Arthroscopy: The Journal of Arthroscopic & Related Surgery

2023

DOI: 10.1016/j.arthro.2023.08.019

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Tranexamic Acid Causes Chondral Injury Through Chondrocytes Apoptosis Induced by Activating Endoplasmic Reticulum Stress

Jiahao Wang,

Shuailong Liang,

Tianliang Ma

et al.

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2024

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Cited by 2 publications

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Brand,

Rossi,

Lubowitz

2024

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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Arthroscopy Honors 2023 Award Winning Publications and Authors

Brand,

Rossi,

Lubowitz

2024

Arthroscopy: The Journal of Arthroscopic & Related Surgery

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Melatonin partially rescues defects induced by tranexamic acid exposure during oocyte maturation in mice

Chen,

Zhang,

Song

et al. 2024

American Journal of Physiology-Cell Physiology

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Tranexamic acid (TXA) is widely used among young women because of its ability to whiten skin and treat menorrhagia. Nevertheless, its potential effects on oocyte maturation and quality have not yet been clearly clarified. Melatonin (MT) is an endogenous hormone released by the pineal gland and believed to protect cells from oxidative stress injury. In the present study, we used in vitro maturation model to investigate the toxicity of TXA and the protective role of MT in mouse oocyte. Compared with the control group, TXA-exposed group had significantly lower nuclear maturation (57.72% vs. 94.08%, P < 0.001) and early embryo cleavage rates (38.18% vs. 87.66%, P < 0.001). Further study showed that spindle organization (52.56% vs. 18.77%, P < 0.01) and chromosome alignment (33.23% vs. 16.66%, P < 0.01) were also disrupted after TXA treatment. Mechanistically, we have demonstrated that TXA induced early apoptosis of oocytes ( P < 0.001) by raising the level of ROS ( P < 0.001), which was consistent with an increase in mitochondrial damage ( P < 0.01). Fortunately, all these effects except the spindle defect were successfully rescued by an appropriate level of MT. Collectively, our findings indicate that MT could partially reverse TXA-induced oocyte quality deterioration in mouse by effectively improving mitochondrial function and reducing oxidative stress-mediated apoptosis.

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Tranexamic Acid Causes Chondral Injury Through Chondrocytes Apoptosis Induced by Activating Endoplasmic Reticulum Stress

Cited by 2 publications

References 58 publications

Arthroscopy Honors 2023 Award Winning Publications and Authors

Arthroscopy Honors 2023 Award Winning Publications and Authors

Melatonin partially rescues defects induced by tranexamic acid exposure during oocyte maturation in mice

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