Tranexamic acid ameliorates rosacea symptoms through regulating immune response and angiogenesis

Li, Yangfan; Xie, Hongfu; Deng, Zhili; Wang, Ben; Tang, Yan; Zhao, Zhixiang; Yuan, Xin; Zuo, Zhihong; Xu, San; Zhang, Yiya; Li, Ji

doi:10.1016/j.intimp.2018.12.031

Cited by 52 publications

(46 citation statements)

References 43 publications

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“…heat, UV-B, stress, Demodex, bacteria) may have a triggering role. 16 Several approaches of anti-inflammation and anti-angiogenesis treatment improve the symptoms. [17][18][19][20] Previous reports have shown an association between rosacea and numerous systemic diseases, such as cardiovascular, gastrointestinal, neurological and autoimmune diseases, and cancers.…”

Section: Discussionmentioning

confidence: 99%

Epidemiological features of rosacea in Changsha, China: A population‐based, cross‐sectional study

Wang

Deng

et al. 2020

The Journal of Dermatology

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Rosacea is a common chronic skin disorder of unknown etiology. While population prevalence rates range 0.2-22% in Europe and North America, prevalence in China is currently undetermined. We conducted a large populationbased case-control study to determine the present epidemiological status of rosacea in China, involving 10 095 participants aged 0-100 years (mean age, 35.5 ± 19.1; 50.5% female). A census of rosacea among 15 communities in Changsha in south central China was conducted with skin examination by board-certified dermatologists. Rosacea was observed in 3.48% (95% confidence interval, 3.13-3.85%) of the study population. Subtype distribution was erythematotelangiectatic in 47.6%, papulopustular in 35.0% and phymatous in 17.4%. Family history was noted in 37.8% and ocular symptoms in 31.3%. Associations with rosacea were observed for melasma, hypertension, hyperthyroidism and breast cancer in females (P < 0.05), and also for hyperthyroidism and peptic ulcers in males (P < 0.05). Our results provide baseline information about epidemiological aspects of rosacea in China.

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Section: Discussionmentioning

confidence: 99%

Epidemiological features of rosacea in Changsha, China: A population‐based, cross‐sectional study

Wang

Deng

et al. 2020

The Journal of Dermatology

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“…Rosacea is a chronic inflammatory disease that can manifest as an increase of inflammatory cytokines and immune cell infiltration . Accumulating epidemiological evidence suggests that chronic inflammation is extremely important in tumor development and progression by immunosuppression .…”

Section: Discussionmentioning

confidence: 99%

“…Rosacea is a chronic inflammatory disease that can manifest as an increase of inflammatory cytokines and immune cell infiltration. 34 Accumulating epidemiological evidence suggests that chronic inflammation is extremely important in tumor development and progression by immunosuppression. 35,36 Continuous activation of inflammation-related signaling pathways, recruitment of cytokines and chemokines (IL-1, IL-6, IL-8, CCL1, CCL2), and increased production of ROS lead to massive immune cell infiltration and neovascularization, thereby promoting tumor microenvironment development.…”

Section: Discussionmentioning

confidence: 99%

Potential association between rosacea and cancer: A study in a medical center in southern China

Long

Yuan

et al. 2019

The Journal of Dermatology

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Growing evidence suggests that rosacea increases the risk of systemic diseases, but studies of the relationships between rosacea and cancer are rare. Aimed to assess the relationship between rosacea and cancer, a total of 7548 patients with confirmed internal malignancies and 8340 cancer‐free individuals aged 18 years or more were included in this study from November 2015 to October 2017. Clinical characteristics, personal history and laboratory data were recorded when patients were diagnosed with rosacea. Logistic regression analyses were performed to analyze associations between cancer and rosacea. We found rosacea significantly affected more women than men in both cancer and cancer‐free group. The data showed there was no relationship between rosacea and lung, gastrointestinal, nasopharyngeal and gynecological cancer. However, rosacea was significantly associated with the increased risk of breast cancer and glioma, but negatively associated with the risk of hematological cancer. Of the 190 female breast cancer patients with rosacea, 98.95% had the erythematotelangiectatic subtype of rosacea, 48.42% had chloasma and 76.31% of them were Fitzpatrick skin type III and IV. In our binary regression model, breast cancer patients with rosacea had a higher prevalence of estrogen receptor‐positive status, lower high‐density lipoprotein levels and higher low‐density lipoprotein than patients with breast cancer but no rosacea. Our findings indicate that rosacea is significantly associated with higher incidence of breast cancer, glioma and lower prevalence of hematological cancer.

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“…Fibroblast cells were cultured in Dulbecco's modified Eagle's medium (DMEM, Hyclone, Logan, USA) with 10% fetal bovine serum (Hyclone, Logan, UT, USA) as previously described (Li et al, 2010). The human keratinocyte HaCaT cells were cultured in free-calcium basal medium (DMEM; Gibco, USA) with 10% fetal bovine serum (Hyclone, Logan, USA) as previously described (Li et al, 2019) in an incubator at 37 • C, 5% CO 2 .…”

Section: Cell Culture and Treatmentmentioning

confidence: 99%

“…Two µg of RNA was reverse transcribed to cDNA. We then performed qPCR to obtain mRNA expression as previously described (Li et al, 2019).…”

Section: Real-time Pcr Analysismentioning

confidence: 99%

Haplopelma hainanum venom induces inflammatory skin lesions

Deng

Wang

Shi

et al. 2020

PeerJ

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The Haplopelma hainanum is a species of theraphosid spider from China. Its large size and charming appearance make this species a popular pet. According to a previous study, theraphosid spider bites can induce pain, erythema, and edema in humans and can present more severely in domestic animals. The pathological consequences of envenomation by H. hainanum remain unclear. In this study, we investigated the effects and mechanisms of H. hainanum envenomation in mice. We showed that the venom induced slight swelling, intense inflammatory response, and increased the microvascular density in mice skin. Moreover, we found that 50 µg/ml of the spider’s venom induced IL-1β expression in both HaCaT cells and fibroblast cells, but repressed CXCL10 expression in fibroblasts. The venom significantly induced cell senescence and repressed cell proliferation and migration in both HaCaT cells and fibroblast cells. Finally, we examined the expression of Nav channel in HaCaT and fibroblast cells and found that H. hainanum venom effectively inhibited Na+ currents in HaCaT cells. Our study calls for further investigation of the pathological consequences and potential mechanisms of H. hainanum envenomation. This information might assist in the development of suitable therapy.

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Tranexamic acid ameliorates rosacea symptoms through regulating immune response and angiogenesis

Cited by 52 publications

References 43 publications

Epidemiological features of rosacea in Changsha, China: A population‐based, cross‐sectional study

Epidemiological features of rosacea in Changsha, China: A population‐based, cross‐sectional study

Potential association between rosacea and cancer: A study in a medical center in southern China

Haplopelma hainanum venom induces inflammatory skin lesions

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