Tranexamic acid achieves less blood loss volume of in primary shoulder arthroplasty: a systematic review and meta-analysis of level I randomized controlled trials

Abstract

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Efficacy and Safety of Oral Tranexamic Acid vs. Other Routes in Total Joint Arthroplasty

“…Recent studies have underscored the effectiveness and safety of TXA in reducing blood loss during total joint arthroplasty (TJA). Its routine use has been linked to reduced postoperative bleeding and lower transfusion requirements [6][7][8][9][10][11][12][13][14][15][16][17] .…”

“…There is a debate in the literature on the optimal regimen of TXA administration. TXA can be administered intravenously, topically, orally, or by multiple routes 1,12,13,15 . Intravenous (IV) administration of TXA has become a standard practice to prevent perioperative blood loss in total knee arthroplasty (TKA) and total hip arthroplasty 18 .…”

The efficacy and safety of intravenous tranexamic acid on blood loss during total ankle replacement: a retrospective study

“…The efficacy and safety of tranexamic acid (TXA) in hip and knee replacement has been extensively studied in the orthopedic department of our hospital [1][2][3][4][5] , and studies have shown that TXA can obviously reduce blood loss and transfusion rate during the perioperative period in total hip and total knee replacement. It has also been reported that the use of TXA in shoulder replacement can reduce perioperative blood loss and complications 6,7 , and the use of TXA in trauma orthopedics and spinal fusion can also significantly reduce perioperative blood loss and related complications [8][9][10] . However, there are few reports on the application of TXA in total ankle replacement (TAR), and the conclusions of the two existing studies are completely opposite.…”