Tramadol-associated mania: A case report

Nimah, Jamaluddin; Chen, Alexander; Gable, Kelly N.; Felthous, Alan R.

doi:10.5055/jom.2017.0386

Cited by 4 publications

(5 citation statements)

References 22 publications

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“…Among the four receptors of the opioidergic system (i.e., mu, delta, kappa, and nociceptin orphanin FQ peptide), actions through mu and kappa receptors have been implicated in mood alteration. While mu agonism is implicated in tramadol-induced mania, 2, 3 kappa agonism also has been reported to have a rapid onset and transient antimanic property. 6 Moreover, buprenorphine, a kappa antagonist and partial mu agonist, may exert an antipsychotic effect through kappa antagonism.…”

Section: Discussionmentioning

confidence: 99%

“…Neetu K Nandan 1 , Lokesh Kumar Singh 1 , Sai Krishna Tikka 1 , Avinash Shukla 2 1 All India Institute of Medical Sciences, Raipur, Chhattisgarh, India. 2 District Hospital, Raipur, Chhattisgarh, India.…”

Section: Patient Consentmentioning

confidence: 99%

“…1 Both opioids-induced and withdrawal emergent mania are not reported frequently and, therefore, less understood. While the opioid most commonly related to induced mania is tramadol, 2, 3 withdrawal emergent mania has been mostly reported with opium. 4, 5 Here, we report the case of a young male with recurrent withdrawal associated manic episodes with the use of poppy husk (locally called “bhukki”) who presented to a tertiary care center of central India.…”

mentioning

confidence: 99%

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Withdrawal Emergent Recurrent Manic Episodes with Use of “Bhukki”: A Case Report

Nandan

Singh

Tikka

et al. 2020

Indian Journal of Psychological Medicine

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Withdrawal EmergentRecurrent Manic Episodes with Use of "Bhukki": A Case Report E vidence suggests a strong association between all mood disorders and substance use disorders. This association has been reported to be threefold to fourfold higher for opioid use disorders compared to other substances. 1 Both opioids-induced and withdrawal emergent mania are not reported frequently and, therefore, less understood. While the opioid most commonly related to induced mania is tramadol, 2,3 withdrawal emergent mania has been mostly reported with opium. 4,5 Here, we report the case of a young male with recurrent withdrawal associated manic episodes with the use of poppy husk (locally called "bhukki") who presented to a tertiary care center of central India.

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Section: Discussionmentioning

confidence: 99%

Section: Patient Consentmentioning

confidence: 99%

mentioning

confidence: 99%

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Withdrawal Emergent Recurrent Manic Episodes with Use of “Bhukki”: A Case Report

Nandan

Singh

Tikka

et al. 2020

Indian Journal of Psychological Medicine

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“…Many studies have reported psychiatric complications associated with tramadol use. Cognitive impairment, manic symptoms, psychotic symptoms, and anxiety symptoms are tramadol users' most common psychiatric symptoms [9,[12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Degenerative brain changes associated with tramadol use: an optical coherence tomography study

Khalil,

Esmael

et al. 2023

Middle East Curr Psychiatry

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Background Tramadol—a synthetic opioid originally used as an analgesic—has been widely misused as an addictive drug in the middle east in the last twenty years. Brain changes associated with long-term tramadol use are understudied. This study aimed to detect the possible effects of tramadol use for at least one year on the brain. Optical coherence tomography (OCT) as a noninvasive measure can assess changes in retinal thickness which reflects degenerative changes in the brain. Methods Twenty-five patients fulfilling the tramadol use disorder according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria were compared to 25 matched control subjects free of substance use disorders. Other psychiatric and medical conditions that may affect OCT were excluded from both groups. Patients were assessed using Addiction Severity Index; meanwhile, both groups were evaluated using OCT. Results Patients with tramadol use showed a lower thickness of most OCT parameters than healthy non-tramadol controls. The retinal nerve fiber layer (RNFL) thickness was not associated with tramadol dose, duration of use, or the age of first use. There were differences between the right and left eyes in RNFL and Ganglion cell complex (GCC) thickness. Conclusions Long-term tramadol use is associated with decreased thickness of RNFL that can be a potential marker and an early sign for degeneration detected by noninvasive techniques like OCT.

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“…The 'atypical' effects of tramadol in withdrawal are perhaps not unexpected when considering the welldescribed range of adverse neurological effects that have been reported with its therapeutic use including serotonin toxicity, hallucinations, psychosis and mania [7][8][9][10][11][12].…”

mentioning

confidence: 99%

Acute tramadol withdrawal: An unusual cause of severe acute behavioural disturbance

Harris

Harburg

Isoardi

2020

Drug and Alcohol Review

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Tramadol-associated mania: A case report

Cited by 4 publications

References 22 publications

Withdrawal Emergent Recurrent Manic Episodes with Use of “Bhukki”: A Case Report

Withdrawal Emergent Recurrent Manic Episodes with Use of “Bhukki”: A Case Report

Degenerative brain changes associated with tramadol use: an optical coherence tomography study

Acute tramadol withdrawal: An unusual cause of severe acute behavioural disturbance

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