Tramadol Added to 1.5% Mepivacaine for Axillary Brachial Plexus Block Improves Postoperative Analgesia Dose-Dependently

Robaux, Sébastien; Blunt, Cornelia; Viel, E.; Cuvillon, Philippe; Nouguier, Philippe; Dautel, G.; Boileau, S.; Girard, Florence; Bouaziz, Hervé

doi:10.1213/01.ane.0000108966.84797.72

Cited by 107 publications

(106 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nevertheless, the value of TRAM as an anesthetic adjunct is uncertain; therefore, caution is necessary. 1 Concerning COD in the PNS, it can produce a dose-dependent and reversible decrement in motor function. 9 Our results further support the concept that combinations of different analgesic modalities could reduce the incidence and severity of pain and patient anxiety.…”

Section: Discussionmentioning

confidence: 99%

“…In this regard, some adjuvant drugs have been proposed to enhance anesthesia and analgesia, such as clonidine, diazepam, morphine, codeine and tramadol. 1 Although modern LAs are effective and safe for most clinical practice, there are some patients who need more comfort. In these cases, an intense search for antinociceptive agents continues, aiming at improving nerve selectivity, promoting less motor block and lowering systemic toxDeclaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of opioids on local anesthesia in the rat: a codeine and tramadol study

et al. 2013

View full text Add to dashboard Cite

Opioids are central analgesics that act on the CNS (central nervous system) and PNS (peripheral nervous system). We investigated the effects of codeine (COD) and tramadol (TRAM) on local anesthesia of the sciatic nerve. Eighty Wistar male rats received the following SC injections in the popliteal fossa: local anesthetic with epinephrine (LA); local anesthetic without vasoconstrictor (LA WV); COD; TRAM; LA + COD; LA + TRAM; COD 20 minutes prior to LA (COD 20' + LA) or TRAM 20 minutes prior to LA (TRAM 20' + LA). As a nociceptive function, the blockade was considered the absence of a paw withdraw reflex. As a motor function, it was the absence of claudication. As a proprioceptive function, it was the absence of hopping and tactile responses. All data were compared using repeated-measures analysis of variance (ANOVA). Opioids showed a significant increase in the level of anesthesia, and the blockade duration of LA + COD was greater than that of the remaining groups (p < 0.05). The associated use of opioids improved anesthesia efficacy. This could lead to a new perspective in controlling dental pain.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of opioids on local anesthesia in the rat: a codeine and tramadol study

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Robaux et al [15] failed to demonstrate an increase in sensory or motor block when tramadol was added to mepivacaine1.5% for brachial plexus block. But Kapral et al [16] demonstrated that the addition of tramadol 100 mg to mepivacaine 1% for axillary plexus block prolonged sensory and motor block compared with mepivacaine alone or axillary block with tramadol 100 mg i.v.…”

Section: Discussionmentioning

confidence: 97%

“…Previous studies showed conflicting results about the efficacy of tramadol as adjuvant to local anesthetics some studies not prove it is efficiency [13][14][15] and others documented that it has a beneficial effect [16,17].…”

Section: Introductionmentioning

confidence: 99%

Dose Addition of Tramadol to Levobupivacaine Femoral Nerve Block Prolong Its Analgesic Efficacy in Patients Undergoing Anterior Cruciate Ligament Reconstruction?

Rashwan¹

2014

Med-Science

View full text Add to dashboard Cite

show abstract

“…Clonidina, antidepressivos e opioides (Strumper;Duriex, 2004), incluindo o tramadol (Kapral et al, 1999;Robaux et al, 2004) (Collins et al, 1997). Também é uma alternativa aos indivíduos em que a associação analgésica de codeína e acetaminofen não é bem tolerada ou contraindicada (Moore, 1999 (Brau et al, 2000).…”

Section: Ordemunclassified

Eficácia analgésica pós-operatória e ação anestésica adjuvante do cloridrato de tramadol utilizado localmente após exodontias de terceiros molares inferiores impactados

Ceccheti¹

View full text Add to dashboard Cite

AGRADECIMENTOSÀ Profa. Dra. Maria da Graça Naclério-Homem, por acreditar sempre em meu potencial, pelo incentivo e apoio nessa jornada de 15 anos pós-graduação. Sua presença em minha vida trouxe oportunidades e desafios superados com grande alegria.À Profa. Maria Paula Siqueira de Melo Peres, por promover o ensino, a pesquisa e assistência na minha segunda casa, o Hospital das Clínicas. Obrigado pelo incentivo constante ao meu desenvolvimento. Foi estudado o efeito analgésico e anestésico adjuvante do cloridrato de tramadol aplicado localmente, após extração do terceiro molar inferior impactado. Um total de 52 pacientes foi submetido à exodontia sob anestesia local (mepivacaína 2% 1:20 000 corbadrina), em estudo duplo-cego, dose única, cruzado, controlado por placebo. Pacientes e os lados dos procedimentos foram distribuídos aleatoriamente para receberem 2 ml de tramadol (100%) (grupo T) ou 2 ml de solução salina 0,9% (grupo P). Ambas as soluções foram injetadas na submucosa gengival e alvéolo, imediatamente após as cirurgias realizadas por um mesmo cirurgião. Impacção dental e quantidade anestésica foram pareadas. Dados do consumo e a hora de uso The present study sought to assess the analgesic and adjuvant anesthetic effects of surgical site administration of tramadol hydrochloride immediately after extraction of impacted mandibular third molars. In this double-blind, placebo-controlled, singledose, crossover investigation, 52 patients underwent bilateral extraction of impacted mandibular third molars under local anesthesia (mepivacaine 2% with levonordefrin 1:20 000). Patients and procedures, by side of intervention, were randomly assigned to receive either 2 mL of tramadol (100%) (Group T, n = 52) or 2 mL of normal saline, 0.9% (Group P, n = 52). Medications were administered by submucosal injection at the level of the third molar immediately after surgery. All patients were operated on by the same surgeon; patients were paired for technical difficulty and amount of anesthetic solution. Use of supplementary analgesics (500 mg metamizole) and time to first postoperative use of a rescue drug were used to assess the analgesic effect of tramadol. Pain level on both sides (Group T and P) was recorded on a visual analog scale (VAS 0-10 cm) immediately after cessation of anesthetic effect and at 4, 8, 24, 48, and 72 hours postoperatively. Data were compared using the Wilcoxon test (p < 0.05). There was no difference in anesthetic blockade between groups. There were no differences in reported adverse effects. In the 72 hours following surgery, patients in group T took significantly fewer (p = 0.008) metamizole tablets (3.37 ± 4.65) than did those in group P (4.4 ± 3.71). Time to first dose of a rescue drug (in minutes) was longer in Group T (303.72 ± 416.01) than in Group P (185.4 ± 59.4) (p = 0.006).Tramadol reduced pain intensity values (VAS) significantly in Group T (3.55 ± 2.27) as compared to Group P (5.26 ± 2.49) after anesthetic effect had worn off (p = 0.001). Local administration of tramadol after oral surg...

show abstract

Tramadol Added to 1.5% Mepivacaine for Axillary Brachial Plexus Block Improves Postoperative Analgesia Dose-Dependently

Cited by 107 publications

References 18 publications

Effects of opioids on local anesthesia in the rat: a codeine and tramadol study

Effects of opioids on local anesthesia in the rat: a codeine and tramadol study

Dose Addition of Tramadol to Levobupivacaine Femoral Nerve Block Prolong Its Analgesic Efficacy in Patients Undergoing Anterior Cruciate Ligament Reconstruction?

Eficácia analgésica pós-operatória e ação anestésica adjuvante do cloridrato de tramadol utilizado localmente após exodontias de terceiros molares inferiores impactados

Contact Info

Product

Resources

About