Tralopyril affects locomotor activity of zebrafish (Danio rerio) by impairing tail muscle tissue, the nervous system, and energy metabolism

Chen, Xiangguang; Teng, Miaomiao; Zhang, Jie; Qian, Le; Duan, Manman; Cheng, Yi; Zhao, Wentian; Wang, Zhao; Wang, Chengju

doi:10.1016/j.chemosphere.2021.131866

Cited by 14 publications

(2 citation statements)

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“…[28] Studies have shown that chlorfenapyr and its metabolites can also aff ect the muscle system and reproductive system. [9,30]…”

Section: Toxicological Datamentioning

confidence: 99%

“…[3] Its metabolite, tralopyril, was accepted in 2014 as a newgeneration alternative antifouling biocide for effectively controlling biological fouling. [9][10][11][12] Tralopyril is often released into the water environment through splashing or soil drainage. [13][14][15][16] Given the high mortality rate associated with chlorfenapyr poisoning, this study aimed to review the mechanisms, clinical presentations, and treatment strategies for chlorfenapyr poisoning.…”

Section: Introductionmentioning

confidence: 99%

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Chlorfenapyr poisoning: mechanisms, clinical presentations, and treatment strategies

Cheng,

Chen,

Wang

et al. 2024

World Journal of Emergency Medicine

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BACKGROUND: Chlorfenapyr is used to kill insects that are resistant to organophosphorus insecticides. Chlorfenapyr poisoning has a high mortality rate and is difficult to treat. This article aims to review the mechanisms, clinical presentations, and treatment strategies for chlorfenapyr poisoning. DATA RESOURCES:We conducted a review of the literature using PubMed, Web of Science, and SpringerLink from their beginnings to the end of October 2023. The inclusion criteria were systematic reviews, clinical guidelines, retrospective studies, and case reports on chlorfenapyr poisoning that focused on its mechanisms, clinical presentations, and treatment strategies. The references in the included studies were also examined to identify additional sources. RESULTS:We included 57 studies in this review. Chlorfenapyr can be degraded into tralopyril, which is more toxic and reduces energy production by inhibiting the conversion of adenosine diphosphate to adenosine triphosphate. High fever and altered mental status are characteristic clinical presentations of chlorfenapyr poisoning. Once it occurs, respiratory failure occurs immediately, ultimately leading to cardiac arrest and death. Chlorfenapyr poisoning is diffi cult to treat, and there is no specifi c antidote.CONCLUSION: Chlorfenapyr is a new pyrrole pesticide. Although it has been identified as a moderately toxic pesticide by the World Health Organization (WHO), the mortality rate of poisoned patients is extremely high. There is no specifi c antidote for chlorfenapyr poisoning. Therefore, based on the literature review, future eff orts to explore rapid and eff ective detoxifi cation methods, reconstitute intracellular oxidative phosphorylation couplings, identify early biomarkers of chlorfenapyr poisoning, and block the conversion of chlorfenapyr to tralopyril may be helpful for emergency physicians in the diagnosis and treatment of this disease.

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“…[28] Studies have shown that chlorfenapyr and its metabolites can also aff ect the muscle system and reproductive system. [9,30]…”

Section: Toxicological Datamentioning

confidence: 99%