Trajectory of Kidney Function: The Canary in Sepsis

Bhatraju, Pavan K.; Wurfel, Mark M.; Himmelfarb, Jonathan

doi:10.1164/rccm.202007-2627ed

Cited by 7 publications

(3 citation statements)

References 19 publications

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“… 36 The limitation of serum creatinine to diagnose acute kidney injury has been underscored, which might result in underestimation of patients with acute kidney injury at acute phase. 37 For the first time, we showed that 13% of patients without acute kidney injury and with normal eGFR at the acute phase had decreased eGFR at follow-up. The persistent follow-up of discharged patients with COVID-19 is necessary and essential, not only to understand the association between extrapulmonary diseases and SARS-CoV-2 infection, but also to find ways to reduce morbidity and mortality by efficient prevention.…”

Section: Discussionmentioning

confidence: 74%

RETRACTED: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

et al. 2021

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Section: Discussionmentioning

confidence: 74%

RETRACTED: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

et al. 2021

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“…Recent reports showed that hypothyroidism patients did not exhibit any heightened risk of SARS-CoV-2 infection. 143 , 144 Conversely, it is conceivable that autoimmune thyroiditis because of SARS-CoV-2 infection-induced “cytokine storm” may develop primary hypothyroidism. On the other hand, the disrupted pituitary axis upon SARS-CoV-2 infection may cause pituitary insufficiency that may result in insufficiency in both thyroid and corticotropic which necessitates levothyroxine and hydrocortisone therapy, respectively.…”

Section: Thyroid Disease Management: Challenges During and Post-covid-19 Scenariomentioning

confidence: 99%

SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases

Murugan¹,

Alzahrani²

2021

JIR

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“…Acute renal failure has been described during COVID-19 and it has been hypothesised that it can persist or evolve into chronic alteration after recovery [12,83]. In 13% of cases, renal impairment could develop in the post-COVID-19 period in patients without renal function alterations in the acute phase [12,83].…”

Section: Renal Failurementioning

confidence: 99%

Post-COVID-19 sequelae

Gramegna¹,

Mantero²,

Amati³

et al. 2021

Covid-19

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Characterisation of the underlying mechanisms of long-term COVID-19 sequelae is still ground for ongoing research; sequelae may result from irreversible organ damage during the acute infection phase, or may reflect the manifestations secondary to a persistent hyperinflammatory state or ongoing viral activity with poor host antibody response. This chapter presents a summary of the evidence available as at October 2021 regarding the different manifestations and severity of post-COVID-19 sequelae in adult patients. Recurrence, relapse and readmission after recoveryRecurrence and relapse of COVID-19Re-infection with SARS-CoV-2 has emerged as a possible outcome after full recovery from COVID-19. Several authors have reported that patients might present with a new positive respiratory sample after previous negative results. TO et al. [7] reported a real case of COVID-19 recurrence; they documented re-infection by a different strain of SARS-CoV-2 with IgG seroconversion. Conversely, KANG et al. [8] analysed 292 re-positive cases from South Korea; patients were asymptomatic or reported minor symptoms and the authors concluded that new positive samples were probably due to previous false-negative laboratory tests or persistent viral shedding rather than real re-infection.A systematic review of published evidence identified 1350 similar cases [9]. The re-positivity occurred mainly in asymptomatic patients; interestingly, only 5.6% of patients were pyrexial mean±SD 34.5±18.7 days after the initial onset of symptoms. Fortunately, the outcome was favourable in the majority of cases (96.7%) and only 2.1% died. GIDARI et al.[9] evaluated a total of nine re-positive patients and inoculated six new positive respiratory samples in Vero-E6 cells showing no growth and negative PCR results. This suggests an absence of live virus in re-positive patients who, therefore, should be considered not contagious. The authors hypothesised that this phenomenon was due to prolonged RNA persistence in the upper respiratory tract [9]. A meta-analysis of potential COVID-19 recurrence included >30,000 publications and analysed patient data for age, sex, time of re-occurrence or relapse of symptoms, and a persistent SARS-CoV-2 PCR test [10]. Relapse occurred after a mean±SD of 34±10.5 days of recovery. This group reported persistent positive SARS-CoV-2 results 39±9 days after the initial positive testing. Relapse predominantly occurred in older individuals with an anergic immune response. There were no reports of any clinical re-infections after a 70-day period following initial infection. Readmission and death in post-COVID-19Readmission and death after hospital discharge contribute to the burden of the disease. An observational study based in a large multihospital system in Michigan (USA) included 2179 hospitalised patients and reported readmission and death within 60 days of discharge in 19.9% and 9.1% of patients, respectively [11]. The most common reasons for readmission were COVID-19 (30.2%), sepsis (8.5%), pneumonia (3.1%) and heart failure ...

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Trajectory of Kidney Function: The Canary in Sepsis

Cited by 7 publications

References 19 publications

RETRACTED: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

RETRACTED: 6-month consequences of COVID-19 in patients discharged from hospital: a cohort study

SARS-CoV-2: Emerging Role in the Pathogenesis of Various Thyroid Diseases

Post-COVID-19 sequelae

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