Trajectories of Depressive Symptoms Before Diagnosis of Dementia

Singh‐Manoux, Archana; Dugravot, Aline; Fournier, Agnès; Abell, Jessica; Ebmeier, Klaus P.; Kivimäki, Mika; Sabia, Séverine

doi:10.1001/jamapsychiatry.2017.0660

Cited by 385 publications

(311 citation statements)

References 37 publications

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“…Responders reported the extent to which 17 DSM‐IV PTSD symptoms had bothered them in the past month, with responses ranging from not at all (1) to extremely (5). Neurodegenerative conditions often cause neuropsychiatric symptoms in the form of anxiety and elevated depressive symptoms [26]; however, recent work has shown that re‐experiencing symptoms are less sensitive to increases in symptomatology seen in cognitively impaired individuals, so the focus in this study was on the symptoms [27]. PTSD symptom severity denotes symptoms summed across the five re‐experiencing symptoms in a standard way and scaled to range from no symptoms (0) to maximal symptoms (1) to facilitate effect size comparison.…”

Section: Methodsmentioning

confidence: 99%

Incidence of mild cognitive impairment in World Trade Center responders: Long‐term consequences of re‐experiencing the events on 9/11/2001

Clouston

Diminich

Kotov

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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Objective This study examined whether World Trade Center (WTC) exposures and chronic posttraumatic stress disorder (PTSD) were associated with incidence of mild cognitive impairment (MCI) in a longitudinal analysis of a prospective cohort study of WTC responders. Methods Incidence of MCI was assessed in a clinical sample of WTC responders (N = 1800) who were cognitively intact at baseline assessment. Crude incidence rates were calculated and compared to population estimates using standardized incidence ratios. Multivariable analyses used Cox proportional‐hazards regression. Results Responders were 53.1 years old (SD = 7.9) at baseline. Among eligible cognitively intact responders, 255 (14.2%) developed MCI at follow‐up. Incidence of MCI was higher than expected based on expectations from prior published research. Incidence was higher among those with increased PTSD symptom severity, and prolonged exposure was a risk factor in apolipoprotein‐ε4 carriers. Conclusions PTSD and prolonged WTC exposures were associated with increased incidence of MCI in WTC responders, results that may portend future high rates of dementia in WTC‐exposed responders.

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Section: Methodsmentioning

confidence: 99%

Incidence of mild cognitive impairment in World Trade Center responders: Long‐term consequences of re‐experiencing the events on 9/11/2001

Clouston

Diminich

Kotov

et al. 2019

Alz & Dem Diag Ass & Dis Mo

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“…Indeed, depressive symptoms might lie in a continuum between subclinical cognitive impairment and overt dementia. In a 28 year follow-up cohort with 10,308 participants, Singh-Manoux and colaborators (2017) 26 also showed that depressive symptoms can be seen as a prodrome of dementia and initiate ten years before the diagnosis of dementia. 26 Taking into account that the great majority of neurodegenerative diseases develops throughout many years, it is conceivable that depressive symptoms might preceed cognitive decline and other clinical features.…”

Section: Depressive Disorders: Risk Factor or A Prodrome Of Dementiamentioning

confidence: 96%

“…In a 28 year follow-up cohort with 10,308 participants, Singh-Manoux and colaborators (2017) 26 also showed that depressive symptoms can be seen as a prodrome of dementia and initiate ten years before the diagnosis of dementia. 26 Taking into account that the great majority of neurodegenerative diseases develops throughout many years, it is conceivable that depressive symptoms might preceed cognitive decline and other clinical features. 27,28 This supports the idea that depressive disorders in elderly population, especially LoD, is a prodrome than a risk factor for dementia.…”

Section: Depressive Disorders: Risk Factor or A Prodrome Of Dementiamentioning

confidence: 96%

Depressive disorders in the elderly and dementia: An update

Dias

Barbosa

Kuang

et al. 2020

Dement. neuropsychol.

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The relationship between depressive disorders in the elderly and dementia, particularly Alzheimer's disease (AD), is highly complex. While the nature of this relationship is still a matter of debate, differential diagnosis and treatment remain a great clinical challenge. We review recent findings on the conundrum of depressive disorders in the elderly and AD. There is a biological continuum between depressive disorders in the elderly -or at least a subgroup of them -and AD. While elderly subjects with depression and patients with AD exhibit higher circulating levels of pro-inflammatory molecules and lower BDNF than matched controls, CSF levels of Aβ42 can discriminate AD from depressive disorders in the elderly. The role of antidepressant treatment as a strategy to minimize the risk of AD remains to be established. A relação entre transtornos depressivos em idosos e demência, particularmente a doença de Alzheimer (DA), é altamente complexa. Embora a natureza desse relacionamento ainda seja motivo de debate, o diagnóstico e o tratamento diferenciais continuam sendo um grande desafio clínico. Revisamos descobertas recentes sobre o dilema de transtornos depressivos em idosos e DA. Existe um contínuo biológico entre os transtornos depressivos em idosos -ou pelo menos um subgrupo deles -e a DA. Enquanto indivíduos idosos com depressão e pacientes com DA exibem níveis circulantes mais altos de moléculas pró-inflamatórias e menor BDNF do que os controles correspondentes, os níveis de Aβ42 no LCR podem discriminar a DA de distúrbios depressivos em idosos. O papel do tratamento antidepressivo como estratégia para minimizar o risco de DA ainda precisa ser estabelecido. Palavras-chave: depressão, demência, Alzheimer, diagnóstico diferencial, terapêutica.

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“…No support was found for the construct that depressive symptoms are a risk factor for dementia. 25 Notably, depressive symptoms have been reported in 30%-50% of patients with AD and are especially common at the prodromal stage. 26 Overt major depression can be diagnosed in 10% of AD patients, mostly during the early to moderately impaired stage 27 and in up to 50% of patients with vascular dementia.…”

Section: Introductionmentioning

confidence: 99%