Trajectories of Depressive Symptoms and Risk of Cognitive Decline and Dementia in Older Women

Petkus, Andrew J.; Espeland, Mark A.; Wang, X; Rapp, Stéphen R.; Casanova, Ramon; Gatz, Margaret; Resnick, Susan M.; Chen, J

doi:10.1093/geroni/igy023.1251

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“…Previous studies have shown long-term PM 2.5 exposure may increase risk of dementia (10), including our report based on WHIMS data (11). Empirical data from WHISCA also showed that GDS-15 trajectories predicted the risk for dementia (data not shown) (45). Taken together, all these data point to two interesting possibilities.…”

Section: Discussionsupporting

confidence: 70%

Particulate Air Pollutants and Trajectories of Depressive Symptoms in Older Women

Petkus¹,

Espeland²,

Wang³

et al. 2018

ISEE Conference Abstracts

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Objectives: Although several environmental factors contribute to the etiology of late-life depressive symptoms, the role of ambient air pollution has been understudied. Experimental data support the neurotoxicity of airborne particulate matter with aerodynamic diameter of ≤ 2.5 μm (PM 2.5 ), but it remains unclear whether long-term exposure is associated with late-life depressive symptoms. Our secondary aim was to explore whether the observed associations between exposure and depressive symptoms are explained by dementia risk.Design, Setting, and Participants: Prospective community-dwelling cohort study from the Women's Health Initiative Study of Cognitive Aging (1999Aging ( -2010. Our analyses included 1,989 older women (baseline age 73.3+3.75) with no prior depression or cognitive impairment.Measurements: Participants completed annual assessments of depressive symptoms (15-item Geriatric Depression Scale). Average ambient PM 2.5 exposure at the residential location was estimated by spatiotemporal modeling for the three-years preceding each neuropsychological

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Section: Discussionsupporting

confidence: 70%