Trajectories of depressive and anxiety symptoms in older adults: a 6‐year prospective cohort study

Holmes, Sophie; Esterlis, Irina; Mazure, Carolyn M.; Lim, Yen Ying; Ames, David; Rainey‐Smith, Stephanie R.; Fowler, Christopher; Ellis, Kathryn A.; Martins, Ralph N.; Salvado, Olivier; Doré, Vincent; Villemagne, Victor L.; Rowe, Christopher C.; Laws, Simon M.; Masters, Colin L.; Pietrzak, Robert H.; Maruff, Paul

doi:10.1002/gps.4761

Cited by 22 publications

(38 citation statements)

References 69 publications

(84 reference statements)

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“…Cognitive dysfunction, particularly executive dysfunction, is common in geriatric depression and increases the risk for poor response to antidepressants . However, findings on the association between cognitive impairment and the clinical course of depression have been divergent in both clinical‐ and population‐based samples, with some studies reporting significant associations and some reporting null findings . Separate processes may be involved in specific domains of cognition and response to depression treatment .…”

Section: Discussionmentioning

confidence: 99%

“…Trajectory groups with greater symptom burden were associated with female sex, low income and education, limited social support, functional impairment, physical illnesses, and initial symptom severity . Difference in the shape of depression trajectories by age groups has also been reported, while findings regarding the impact of cognition have been mixed …”

Section: Introductionmentioning

confidence: 99%

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Trajectories of major depression in middle‐aged and older adults: A population‐based study

Xiang

Cheng

2019

Int J Geriat Psychiatry

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Objectives This study aimed to examine depression trajectories and correlates in a nationally representative sample of middle‐aged and older adults in the United States. Methods The study sample consisted of 15 661 participants aged over 50 years from the US Health and Retirement Study. Major depression was assessed using the Composite International Diagnostic Interview (CIDI‐SF). Depression trajectories were identified using a group‐based trajectory modeling enhanced to account for nonrandom attrition. Multinomial logistic regression was conducted to investigate predictors of depression trajectories. Results Four depression trajectory groups were identified: “never” (85.8%), “increasing” (6.3%), “decreasing” (3.2%), and “persistently moderate/high” (4.7%). Baseline depressive symptom severity was a strong predictor of depression trajectories. Older age, male sex, and non‐Hispanic African American race were associated with a lower risk of the three trajectories with small to high depression burden, whereas chronic disease count was associated with a higher risk of these trajectories. The risk of being on the increasing trajectory increased with mobility difficulties. Difficulties in household activities predicted membership in the persistently moderate/high group. Conclusions A small but nonignorable proportion of middle‐aged and older adults have chronic major depression. Initial symptom severity and chronic disease burden are consistent risk factors for unfavorable depression trajectories and potential targets for screening and intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trajectories of major depression in middle‐aged and older adults: A population‐based study

Xiang

Cheng

2019

Int J Geriat Psychiatry

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“…Person-centred methods have highlighted the presence of varying, heterogeneous trajectories of depressive symptoms (Holmes et al, 2017;Hsu, 2012;Kuchibhatla et al, 2012). Recently, a systematic review has provided consistent evidence on depressive symptom trajectories, underlying the overall course, across the lifespan (Musliner et al, 2016).…”

Section: Long-term Trajectories Of Depressive Symptoms In Old Age: Rementioning

confidence: 99%

Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors

Torre‐Luque

Prina

et al. 2019

Journal of Affective Disorders

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Published in: De la Torre-luque A, De la Fuente J, Prina M, Sanchez-Niubo A, Haro JM, Ayuso-Mateos JL. Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors. Abstract Background. This study aimed at depicting the course of depression symptoms over the old age, with a special interest in a) uncovering its relationships with sociodemographic and health-related factors; b) analysing its predictive role on healthyageing outcomes later in life. Methods. The sample comprised 8317 older adults (46.02% men) from the English Longitudinal Study of Ageing. Robust structural equation modelling was used to identify symptom trajectories and their relationships with time-varying factors. Trajectory class and covariates were used to predict outcomes (quality of life, satisfaction with life, and daily living functioning) in a 2-year follow-up. Results. Three trajectory classes (so-called, normative, subclinical, chronic symptom trajectories) were identified for both sexes. Rising hearing difficulties and history of psychiatric problems were consistently associated with the chronic symptom trajectory. Lower education level, history of psychiatric problems, and increasing visual difficulties were connected with the subclinical trajectories. Finally, participants with either a subclinical or a chronic symptom trajectory showed worse outcomes than the remaining participants in the follow-up. Conclusion: This study highlighted the presence of varying courses of depression symptoms (each showing some distinctive features from other another) over the old age, pointing to some relevant implications for clinical assessment and treatment prescription.

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“…In these models, underlying subgroups within a population are identified and a growth curve for each subgroup is estimated . Several studies have examined trajectories of depressive symptoms and found symptom development to be highly heterogeneous . However, these studies were either conducted among the general population or among patients suffering from unipolar depressive disorder .…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have examined trajectories of depressive symptoms and found symptom development to be highly heterogeneous . However, these studies were either conducted among the general population or among patients suffering from unipolar depressive disorder . Only few clinical studies have performed trajectory analyses to explore symptom development among patients with bipolar disorder, and none of these have investigated how depressive symptoms improve over time .…”

Section: Introductionmentioning

confidence: 99%

Patterns of changes in bipolar depressive symptoms revealed by trajectory analysis among 482 patients with bipolar disorder

et al. 2018

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Introduction: Depressive episodes are often prevalent among patients with bipolar disorder, but little is known regarding the differential patterns of development over time. We aimed to determine and characterize trajectories of depressive symptoms among adults with bipolar disorder during 6 months of systematic treatment. Methods: The pragmatic clinical trial, Bipolar Clinical Health Outcomes Initiative inComparative Effectiveness (CHOICE), randomized 482 outpatients with bipolar disorder to lithium or quetiapine. Depressive symptoms were rated at up to 9 visits using the Montgomery-Asberg Depression Rating Scale (MADRS). Growth mixture modeling was utilized to identify trajectories and multinomial regression analysis estimated associations with potential predictors.Results: Four distinct trajectories of depressive symptoms were identified. The responding class (60.3%) with a rapid reduction and subsequent low level; the

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Trajectories of depressive and anxiety symptoms in older adults: a 6‐year prospective cohort study

Abstract: Our results indicate distinct and sex-specific risk factors linked to depressive and anxiety trajectories, which may help inform risk stratification and management of these symptoms in older adults at risk for Alzheimer's disease. Copyright © 2017 John Wiley & Sons, Ltd.

Cited by 22 publications

References 69 publications

Trajectories of major depression in middle‐aged and older adults: A population‐based study

Trajectories of major depression in middle‐aged and older adults: A population‐based study

Long-term trajectories of depressive symptoms in old age: Relationships with sociodemographic and health-related factors

Patterns of changes in bipolar depressive symptoms revealed by trajectory analysis among 482 patients with bipolar disorder

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