Trajectories of change in cognitive function in people with chronic obstructive pulmonary disease

Park, Soo Kyung

doi:10.1111/jocn.14285

Cited by 12 publications

(10 citation statements)

References 57 publications

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“…They influence the rate of differentiation and apoptosis of cerebral cells [137] and regulate long-term potentiation [138] and hippocampal neurogenesis [137]. Multiple previous studies have shown the benefit of exercise on cognition in COPD patients [139,140], and in the study by Park et al the 6-minute walking distance was the only potentially modifiable variable that was related to worsening cognitive functioning over time [27]. The question remains, however, whether these improvements consolidate into the longer term if exercise is discontinued [11].…”

Section: Exercise Trainingmentioning

confidence: 98%

“…This surprising result might be explained by survival bias rather than the effects of COPD itself [26]. In a recent study, 32.6% of patients taking part in the National Emphysema Treatment Trial (NETT) were impaired on part B of the Trail Making Test (TMT) at baseline [27]. This test measures task switching, which is part of executive functioning.…”

Section: Longitudinal Studiesmentioning

confidence: 99%

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Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

Beers

Janssen

Gosker

et al. 2018

Expert Review of Respiratory Medicine

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Introduction: Cognitive impairment (CI) is an important but an under-recognized extra-pulmonary feature of chronic obstructive pulmonary disease (COPD). It is related to the burden of disability, worse health outcomes, and impaired self-management. Areas covered: CI includes deterioration of a wide range of cognitive functions, such as memory and various executive functions. Risk of hospitalization might be higher in patients with COPD compared to those without, with CI negatively impacting the wellbeing of patients with COPD. Disease-specific factors such as hypoxemia and inflammation, lifestyle factors such as dietary insufficiencies and lack of physical activity, and comorbidities such as obstructive sleep apnea and depression are likely to synergistically contribute to the development of CI in COPD. Tailored interventions can possibly improve CI in COPD, but this needs further investigation. Expert commentary: Further research is warranted involving the optimization of neuropsychological testing for screening and outcome assessment, longitudinal studies to investigate the development of CI in COPD over time, and randomized clinical trials to test the feasibility and efficacy of promising interventions.

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Section: Exercise Trainingmentioning

confidence: 98%

Section: Longitudinal Studiesmentioning

confidence: 99%

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

Beers

Janssen

Gosker

et al. 2018

Expert Review of Respiratory Medicine

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“…Cognitive impairment in elderly patients with COPD is affected by various factors, including disease-specific factors such as hypoxemia, 19 hypercapnia, 20 and systemic inflammation, 21 and lifestyle factors such as diet deficiency, 22 and lack of physical activity; 23,24 Other factors, such as aging, 25 long-term smoking, 26,27 education, 28 severity, and course of the disease, 29 may lead to abnormality in the brain structure and function in COPD patients, resulting in cognitive impairment. Moreover, elderly patients with COPD varying in degrees of synergy are often accompanied by cerebrovascular disease, anxiety and depression, sleep disorders, metabolic syndrome and other complications.…”

Section: Influencing Factors Of Cognitive Impairment In Elderly Patiementioning

confidence: 99%

<p>Influencing Factors and Exercise Intervention of Cognitive Impairment in Elderly Patients with Chronic Obstructive Pulmonary Disease</p>

Wang¹,

Mao²,

Wang³

et al. 2020

CIA

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Chronic obstructive pulmonary disease (COPD) is a common respiratory condition characterized by airflow limitation in the elderly. Airflow limitation is partially reversible and progressive. COPD not only causes a gradual decline in lung function but also affects the function of other systems throughout the body; it also has adverse effects on the central nervous system that can lead to cognitive impairment, especially in elderly patients. Therefore, understanding the influencing factors of cognitive impairment in elderly patients with COPD and applying early intervention are crucial in improving the quality of life of patients and reducing the burden on their families and society. This article mainly discusses the related factors of cognitive impairment in elderly patients with COPD and expands the possible mechanism of exercise in improving cognitive impairment in patients with COPD to provide a reference for the clinical prevention and treatment of cognitive impairment in elderly patients with COPD.

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“…However, these results are primarily from relatively healthy populations, with normal levels of cognitive functioning, and perhaps leave little room for improvement. Individuals with COPD more frequently experience cognitive impairment (10); approximately 56.7% of patients with COPD are affected by cognitive impairment, compared to 13.3% of aged matched peers (10), which can also worsen over time (25,26). When cognitive function is affected, typically attention, memory, executive functions and WM are affected (27,28).…”

Section: Why Consider Cognitive Training In the Overall Management Ofmentioning

confidence: 99%

A randomised placebo-controlled study into the feasibility and efficacy of working memory training in chronic obstructive pulmonary disease: the study protocol

Mount¹,

Houben²,

Gosker³

et al. 2019

Preprint

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Background General cognitive impairment is highly prevalent in patients with chronic obstructive pulmonary disease (COPD). Domain-specific cognitive impairments include deficits in working memory (WM), cognitive flexibility, verbal memory, planning and psychomotor speed. These impairments may be associated with poor health behaviours, such as a sedentary lifestyle and low-quality diet. Cognitive training may reverse these effects. Recent evidence suggests that WM training is linked to self-control and, indirectly, to improved lifestyle behaviour including increased physical activity. We aim to investigate the efficacy of WM training (WMT) in patients with COPD on cognitive performance, cognitive stress susceptibility and perception, self-control, and adherence to personalised physical activity and dietary behaviour goals. Methods A double blind, placebo-controlled randomised trial will be conducted in 60 patients with COPD. The trial will consist of two phases; 12 weeks of active WM training or sham training followed by 12 weeks of maintenance. Prior to the WMT, before the first phase, participants in both the sham (n=30) and training group (n=30) will set dietary and physical activity goals based on their dietary intake and physical activity profile using validated tools. Cognitive performance will be examined using the Cambridge Neuropsychological Test Automated Battery. The primary outcome of this study will be change in cognitive performance. Secondary outcomes will be self-control (impulsivity), compliance, stress susceptibility and perception, change in dietary intake and daily physical activity level and pattern. Discussion This trial will attempt to determine if cognitive performance can be improved in patients with COPD by WMT. Moreover, WM plays a key role in self-regulation of behaviour, i.e. resisting hedonic impulses in exchange for more deliberate evaluations and the achievement of long-term goals. Therefore, we expect that WMT will also have a positive impact on health behaviours. Registration Clinicaltrials.gov registration: NCT03073954, https://clinicaltrials.gov/ct2/show/NCT03073954?term=NCT03073954&rank=1

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Trajectories of change in cognitive function in people with chronic obstructive pulmonary disease

Cited by 12 publications

References 57 publications

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

<p>Influencing Factors and Exercise Intervention of Cognitive Impairment in Elderly Patients with Chronic Obstructive Pulmonary Disease</p>

A randomised placebo-controlled study into the feasibility and efficacy of working memory training in chronic obstructive pulmonary disease: the study protocol

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