Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use during adolescence

Lannoy, Séverine; Sullivan, Edith V.

doi:10.1016/bs.irn.2021.08.002

Cited by 3 publications

(2 citation statements)

References 131 publications

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“…Age-related differences in alcohol consumption is well documented [56,57]. More recent data show that 39.7% of 12-to 20-year-olds admitted to having at least one drink in their lifetimes, showing how as time progresses, consumption of alcohol in the young decreases.…”

Section: Impacts Of Agementioning

confidence: 93%

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

Sureshkumar¹,

Guo²,

Tran³

et al. 2022

Preprint

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Alcohol use disorder (AUD) represents major public and socioeconomic issues. Alcohol exerts its phar-macological effects by altering different neurotransmitter systems, such as g-aminobutyric acid (GABA), glutamate, opioids, etc. Recent evidence suggests that the dynorphin (DYN)/kappa opioid receptor (KOR) system mediates the negative affective states associated with alcohol withdrawal. This system is also in-volved in stress-mediated alcohol intake in alcohol-dependent subjects. The DYN/KOR system probably exerts its action in the central nucleus of the amygdala (CeA) to mediate the negative affective states as-sociated with alcohol withdrawal. This article aims to review the current literature regarding the role of the DYN/KOR system in the actions of alcohol. We first review the literature regarding the effect of alcohol on the level of the peptide and its receptor, and the role of the endogenous DYN/KOR system in alcohol reward and negative affective states associated with alcohol withdrawal is then discussed. We also review the literature regarding the effects of KOR ligands on these processes.

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Section: Impacts Of Agementioning

confidence: 93%

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

Sureshkumar¹,

Guo²,

Tran³

et al. 2022

Preprint

View full text Add to dashboard Cite

show abstract

“…Age-related differences in alcohol consumption are well documented [61,62]. More recent data show that 39.7% of 12-to 20-year-olds have admitted to having at least one drink in their lifetimes, showing how, as time progresses, the consumption of alcohol in the young decreases.…”

Section: Impacts Of Agementioning

confidence: 94%

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

Sureshkumar¹,

Guo

Tran

et al. 2022

Psychoactives

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Alcohol use disorder (AUD) represents major public and socioeconomic issues. Alcohol exerts its pharmacological effects by altering different neurotransmitter systems, such as g-aminobutyric acid (GABA), glutamate, opioids, etc. Recent evidence suggests that the dynorphin (DYN)/kappa opioid receptor (KOR) system mediates the negative affective states associated with alcohol withdrawal. This system is also involved in stress-mediated alcohol intake in alcohol-dependent subjects. The DYN/KOR system probably exerts its action in the central nucleus of the amygdala (CeA) to mediate the negative affective states associated with alcohol withdrawal. This article aims to review the current literature regarding the role of the DYN/KOR system in the actions of alcohol. We first review the literature regarding the effect of alcohol on the level of the peptide and its receptor, and the role of the endogenous DYN/KOR system in alcohol reward and negative affective states associated with alcohol withdrawal is then discussed. We also review the literature regarding the effects of KOR ligands on these processes.

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Consumo de Alcohol en Adolescentes: Estrategias Derivadas de la Neuroeducación para la Prevención y Promoción de Hábitos Saludables

Peñuela-Velásquez,

Mendoza-Múzquiz,

Martínez-Saldaña

et al. 2024

Revista Científica y Académica

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El consumo de alcohol es un problema de salud pública en la mayor parte de países en donde esta práctica está legalizada y es incentivada y reforzada por la publicidad, el comercio y la cultura, llegando a tornarse más problemática en las etapas tempranas de desarrollo del ser humano, en este caso, se hace énfasis en las afectaciones y alteraciones que el consumo de alcohol de manera habitual, conlleva sobre las poblaciones adolescentes y juveniles. Este artículo de revisión ha tenido como objetivo, retomar un conjunto de investigaciones en donde se evidencien los efectos adversos del alcohol en adolescentes y sobre las ventajas y fortalezas que podría tener el uso de técnicas y herramientas provistas por la neuroeducación para prevenir y mitigar el consumo de alcohol. Como conclusiones, se recomienda que los sistemas educativos puedan hacer uso de la neuroeducación para la generación de programas y proyectos diseñados por expertos en este campo, con el fin de velar por el sano y adecuado desarrollo de la adolescencia y la juventud escolarizadas que se están viendo cada vez más afectadas por el consumo habitual de alcohol.

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Trajectories of brain development reveal times of risk and factors promoting resilience to alcohol use during adolescence

Cited by 3 publications

References 131 publications

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

The Role of the Dynorphin/Kappa Opioid Receptor System in the Actions of Alcohol

Consumo de Alcohol en Adolescentes: Estrategias Derivadas de la Neuroeducación para la Prevención y Promoción de Hábitos Saludables

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