Trajectories of Alcohol Initiation and Use During Adolescence: The Role of Stress and Amygdala Reactivity

Elsayed, Nourhan M.; Kim, M. Justin; Fields, Kristina M.; Olvera, Rene L.; Hariri, Ahmad R.; Williamson, Douglas E.

doi:10.1016/j.jaac.2018.05.011

Cited by 42 publications

(19 citation statements)

References 69 publications

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“…This is in line with the self-medication theory whereby substances are used to mediate mood disorders or innate reward deficiencies (9). Also, adolescents with high stress and amygdala reactivity are more likely to consume a full standard alcoholic drink, are more likely to experience early intoxication, and are at a heightened risk for the onset of an alcohol use disorder (57). In line with this, anhedonia can be hypothesized as a vulnerability trait for early substance use trajectories and subsequent increase of DUS risk.…”

Section: Discussionmentioning

confidence: 99%

Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review

et al. 2019

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Background: Recently, anhedonia has been recognized as an important Research Domain Criterion (RDoC) by the National Institute of Mental Health. Anhedonia is proposed to play an essential role in the pathogenies of both addictive and mood disorders, and possibly their co-occurrence with a single individual. However, up to now, comprehensive information about anhedonia concerning its underlying neurobiological circuitries, the neurocognitive correlates, and their role in addiction, mood disorder, and comorbidity remains scarce. Aim: In this literature review of human studies, we bring together the current state of knowledge with respect to anhedonia in its relationship with disorders in the use of substances (DUS) and the comorbidity with mood disorders. Method: A PubMed search was conducted using the following search terms: (Anhedonia OR Reward Deficiency) AND ((Drug Dependence OR Abuse) OR Alcohol OR Nicotine OR Addiction OR Gambling OR (Internet Gaming)). Thirty-two articles were included in the review. Results: Anhedonia is associated with substance use disorders, and their severity is especially prominent in DUS with comorbid depression. Anhedonia may be both a trait and a state dimension in its relation to DUS and tends to impact DUS treatment outcome negatively.

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Section: Discussionmentioning

confidence: 99%

Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review

et al. 2019

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“…Oshri et al [ 144 ] showed that ELS-related changes in AMG volume were associated with increased anxiety, depressive symptoms, and alcohol use. Heightened threat-related AMG reactivity has been shown to predict internalizing symptoms [ 145 ] and risks for alcohol use disorder [ 146 , 147 ]. In contrast, ELS has been associated with reduced mPFC volume [ 148 , 149 ] and lower mPFC activation during both resting state and cognitive tasks [ 150 , 151 , 152 ].…”

Section: Role Of Mesocorticolimbic Emotion Processing Circuits In Els and Oudmentioning

confidence: 99%

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Oswald

Dunn

Seminowicz

et al. 2021

JPM

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A robust body of research has shown that traumatic experiences occurring during critical developmental periods of childhood when neuronal plasticity is high increase risks for a spectrum of physical and mental health problems in adulthood, including substance use disorders. However, until recently, relatively few studies had specifically examined the relationships between early life stress (ELS) and opioid use disorder (OUD). Associations with opioid use initiation, injection drug use, overdose, and poor treatment outcome have now been demonstrated. In rodents, ELS has also been shown to increase the euphoric and decrease antinociceptive effects of opioids, but little is known about these processes in humans or about the neurobiological mechanisms that may underlie these relationships. This review aims to establish a theoretical model that highlights the mechanisms by which ELS may alter opioid sensitivity, thereby contributing to future risks for OUD. Alterations induced by ELS in mesocorticolimbic brain circuits, and endogenous opioid and dopamine neurotransmitter systems are described. The limited but provocative evidence linking these alterations with opioid sensitivity and risks for OUD is presented. Overall, the findings suggest that better understanding of these mechanisms holds promise for reducing vulnerability, improving prevention strategies, and prescribing guidelines for high-risk individuals.

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“…In line with animal models demonstrating that neuroplastic changes in the striatum mediate exaggerated salience to drug cues at the expense of natural rewards and habitual responses to cues repeatedly paired with the drug (Robbins, Ersche, & Everitt, 2008), exaggerated striatal drug cue reactivity and blunted striatal processing of nondrug rewards has been demonstrated in functional MRI studies in human drug users with regular and addictive use of different substances (Chase, Eickhoff, Laird, & Hogarth, 2011; Kühn & Gallinat, 2011; Vollstädt‐Klein et al, 2010; Zhou et al, 2019; Zimmermann et al, 2019). However, despite convergent evidence for striatal maladaptations across different substance use disorders, substance‐specific predisposing factors (Becker et al, 2015; Cheng et al, 2019; Elsayed et al, 2018; Zilberman, Yadid, Efrati, & Rassovsky, 2019) and addiction‐related alterations have been increasingly recognized, such that frontal regions have been found to be differentially impacted by stimulant or opioid use (Badiani, Belin, Epstein, Calu, & Shaham, 2011) and neurocognitive deficits in domains associated with frontostriatal circuits such as inhibitory control and cognitive flexibility have been found to be differentially impacted by alcohol, stimulants, and cannabis (Fernández‐Serrano, Pérez‐García, & Verdejo‐García, 2011; Smith, Mattick, Jamadar, & Iredale, 2014). Further evidence for substance use disorder‐specific brain alterations comes from a recent qualitative review suggesting that different addictions may be associated with alterations in distinct brain systems and particularly alterations in frontal regions appear to be substance‐specific (Zilberman, Lavidor, Yadid, & Rassovsky, 2019).…”

Section: Introductionmentioning

confidence: 99%

Common and separable neural alterations in substance use disorders: A coordinate‐based meta‐analyses of functional neuroimaging studies in humans

Klugah‐Brown

Zweerings

et al. 2020

Human Brain Mapping

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Delineating common and separable neural alterations in substance use disorders (SUD) is imperative to understand the neurobiological basis of the addictive process and to inform substance-specific treatment strategies. Given numerous functional MRI (fMRI) studies in different SUDs, a meta-analysis could provide an opportunity to determine robust shared and substance-specific alterations. The present study employed a coordinate-based meta-analysis covering fMRI studies in individuals with addictive cocaine, cannabis, alcohol, and nicotine use. The primary meta-analysis

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Trajectories of Alcohol Initiation and Use During Adolescence: The Role of Stress and Amygdala Reactivity

Cited by 42 publications

References 69 publications

Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review

Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review

Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings

Common and separable neural alterations in substance use disorders: A coordinate‐based meta‐analyses of functional neuroimaging studies in humans

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