Trajectories of Acute Diabetes-Specific Stress in Adolescents With Type 1 Diabetes and Their Caregivers Within the First Year of Diagnosis

Yi‐Frazier, Joyce P.; Cochrane, Katie; Whitlock, Kathryn B.; Rosenberg, Abby R.; Pascual, Michael; Beauregard, Natalie; Mitrovich, Connor; Panlasigui, Neil; Pihoker, Catherine

doi:10.1093/jpepsy/jsy003

Cited by 13 publications

(3 citation statements)

References 45 publications

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“…One limitation of the current study is that the sample was predominantly married mothers, so it is possible that it lacked variability to detect effects. Results on race/ethnicity confirm findings from other studies showing no differences in psychosocial functioning by parent racial/ethnic background at the time of T1D diagnosis (Yi-Frazier et al, 2018); other studies have demonstrated more difficulties with parent psychosocial functioning for parents of color compared with non-Hispanic White parents a few years after diagnosis (Caccavale et al, 2015;Driscoll et al, 2010;Streisand et al, 2010). Overall, results may show that the acute intensity of diagnosis impacts families in a significant way and that later health disparities emerge over time due to social segregation and differential access to quality care, health care policies, intergenerational effects of stress, and other aspects rooted in systemic racism (Gee & Ford, 2011).…”

Section: Discussionsupporting

confidence: 86%

Diabetes-specific functioning in parents of young children with recently diagnosed type 1 diabetes.

Tully¹,

Wang²,

Sinisterra³

et al. 2022

Health Psychology

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Objective: A Type 1 diabetes (T1D) diagnosis in young children can cause significant family stress. Parents may experience increased depressive symptoms, but less is known about early diabetes-specific functioning (i.e., parental self-efficacy to manage diabetes, hypoglycemia fear, and coparenting conflict). We evaluated a theoretically based model of diabetes-specific functioning among parents of young children newly diagnosed with T1D (YC-T1D). The model included parent demographic variables, child illness-factors, family protective factors, and general parent emotional functioning. Method: One hundred fifty-seven newly diagnosed YC-T1D (M age = 4.4 6 1.7 years; M days postdiagnosis = 29.0 6 15.4) and their primary caregivers (91.7% female; 61% non-Hispanic White) were assessed at baseline of a behavioral intervention randomized controlled trial. We used psychosocial measures to explore hypothesized domains associated with parents' diabetes-specific functioning using structural equation modeling. Results: More difficulties with parent emotional functioning were related to more problems with parent diabetes-specific functioning, and higher family protective factors were related to fewer problems with diabetes-specific functioning. Child-illness factors were also directly related to more difficulties with parent diabetes-specific functioning and emotional functioning. Parents with college education reported more difficulties with emotional functioning and parent diabetes-specific functioning. Younger child age was associated with fewer difficulties with emotional functioning and more family protective factors. Conclusions: Results provide initial support for a model of parent diabetes specific-functioning at young child T1D diagnosis. Future research may examine this model in relation to children's glycemic outcomes over the first year after diagnosis. Implications are made for parent screening at the time of YC-T1D diagnosis.

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Section: Discussionsupporting

confidence: 86%

Diabetes-specific functioning in parents of young children with recently diagnosed type 1 diabetes.

Tully¹,

Wang²,

Sinisterra³

et al. 2022

Health Psychology

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“…Yi-Frazier et al [ 20 ] found that families and individuals of adolescents with type 2 diabetes are experiencing significant psychological stress.…”

Section: Resultsmentioning

confidence: 99%

Identifying diseases that cause psychological trauma and social avoidance by GCN-Xgboost

Wang

Yuan

et al. 2020

BMC Bioinformatics

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Background With the rapid development of medical treatment, many patients not only consider the survival time, but also care about the quality of life. Changes in physical, psychological and social functions after and during treatment have caused a lot of troubles to patients and their families. Based on the bio-psycho-social medical model theory, mental health plays an important role in treatment. Therefore, it is necessary for medical staff to know the diseases which have high potential to cause psychological trauma and social avoidance (PTSA). Results Firstly, we obtained diseases which can cause PTSA from literatures. Then, we calculated the similarities of related-diseases to build a disease network. The similarities between diseases were based on their known related genes. Then, we obtained these diseases-related proteins from UniProt. These proteins were extracted as the features of diseases. Therefore, in the disease network, each node denotes a disease and contains the information of its related proteins, and the edges of the network are the similarities of diseases. Then, graph convolutional network (GCN) was used to encode the disease network. In this way, each disease’s own feature and its relationship with other diseases were extracted. Finally, Xgboost was used to identify PTSA diseases. Conclusion We developed a novel method ‘GCN-Xgboost’ and compared it with some traditional methods. Using leave-one-out cross-validation, the AUC and AUPR were higher than some existing methods. In addition, case studies have been done to verify our results. We also discussed the trajectory of social avoidance and distress during acute survival of breast cancer patients.

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“…Assessments were completed during regular check-ups or at home by young patients living with T1DM on average for more than 5 years (range between 0 and 14 years). Thus, it can be assumed that diabetes management was well-adjusted and most participants were in stable health situations, where disease-related symptoms and the management of T1DM was only minimally affecting their generic HRQL (49,50). However, further studies are needed to investigate the effect of the prolonged T1DM remission phase on HRQL.…”

Section: Discussionmentioning

confidence: 99%

Trajectories of Health-Related Quality of Life and HbA1c Values of Children and Adolescents With Diabetes Mellitus Type 1 Over 6 Months: A Longitudinal Observational Study

Fischer

Barthel

et al. 2020

Front. Pediatr.

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Introduction: To achieve optimized blood glucose concentrations (assessed by HbA1c) and high health-related quality of life (HRQL), children and adolescents with diabetes mellitus type 1 (T1DM) must follow strict disease management strategies. This study aims to investigate HRQL of children and adolescents with T1DM and its association with HbA1c values over the course of 6 months. Methods: Patients aged 7-17 years (n = 203) with T1DM provided HRQL data on a monthly basis. HRQL was measured using the Kids-CAT, a computer-adaptive test (CAT) comprising five generic HRQL domains. HbA1c concentrations were assessed at baseline, at 3 and 6 months. We explored the trajectory of HRQL at the domain level using linear mixed effects models. Further, we investigated the association between HRQL and HbA1c concentrations over time using path analysis models. Results: Children and adolescents with T1DM reported high scores across all HRQL domains over time. However, those with an HbA1c concentrations of >9.0% reported significantly lower scores in physical well-being and parent relations compared with those with an HbA1c concentration of <7.5%. Path analysis models revealed a minimal temporal relationship between HbA1c and HRQL, with a small negative impact of HbA1c on physical well-being, psychological well-being and parent relations. Conclusion: Although observed HRQL of young patients with T1DM was comparable to age-related German-speaking reference population over the course of 6 months, those with an HbA1c concentration >9.0% reported lower scores in selected HRQL domains. Fischer et al. Longitudinal Quality of Life of Children With T1DM Thus, special attention should be drawn to HRQL of children and adolescents with higher HbA1c concentrations. The minimal relationship between HbA1c and HRQL indicates that the two therapy goals, i.e., achievement and maintenance of glycemic targets and high HRQL, should be considered and evaluated independently in clinical routine. Trial Registration: DRKS00006326 (German Clinical Trial Register), date of registration: August 1st, 2014.

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Trajectories of Acute Diabetes-Specific Stress in Adolescents With Type 1 Diabetes and Their Caregivers Within the First Year of Diagnosis

Cited by 13 publications

References 45 publications

Diabetes-specific functioning in parents of young children with recently diagnosed type 1 diabetes.

Diabetes-specific functioning in parents of young children with recently diagnosed type 1 diabetes.

Identifying diseases that cause psychological trauma and social avoidance by GCN-Xgboost

Trajectories of Health-Related Quality of Life and HbA1c Values of Children and Adolescents With Diabetes Mellitus Type 1 Over 6 Months: A Longitudinal Observational Study

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