Traitements médicaux chez la femme ayant des myomes symptomatiques en période d’activité génitale

Koskas, Martin; Derrien, Jean

doi:10.1016/j.lpm.2013.02.318

Cited by 3 publications

(2 citation statements)

References 24 publications

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“…Koskas and Derrien 11 study showed that Letrozole is as effective as GnRH agonists in reduction of fibroid size with less hot flush and the use of GnRH agonist is effective to decrease of uterine bleeding and correction of hemoglobin level, also add-back therapy with tibolone seems to reduce the hypoestrogenism symptoms of GnRH agonists.…”

Section: Discussionmentioning

confidence: 98%

“…Koskas and Derrien 11 study reported that surgical technique in cases of uterine fibroids are traditional and high recurrence rates and adhesion formation (pain-infertility) are the complication of surgical intervention. Both clinical trial and in vitro investigations have shown that aromatase inhibitor might reduce the growth of fibroid and so to prevent surgical intervention.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Gonadotropin-releasing Hormone Agonist Plus Aromatase Inhibitor in the Treatment of Uterine Leiomyoma in Near Menopause Patient: A Case Series Study

Moradan

2018

J Menopausal Med

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ObjectivesThere are many drugs for of symptomatic fibroids. Gonadotropin-releasing hormone (GnRH) agonists are the well known drugs. Also, aromatase inhibitors are effective. All published studies surveyed the effect of one of these two drugs. In this study as the first study decided to evaluate the effectiveness of the combination of GnRH agonists + aromatise inhibitor on the uterine fibroids.MethodsA cross-sectional prospective case series study was performed on 10 known cases of uterine fibroids late perimenopause, at least 3 myomas >5 cm, abnormal uterine bleeding and anemia due to fibroids, candidate for hysterectomy, no tendency to surgery. A single dose of Diphereline 11.25 mg, SR plus 2.5 mg of Letrozole daily for 4 weeks with add-back therapy + calcium carbonate were used. The second dose of Diphereline 11.25 mg, SR was used 3 months after the first injection. The patients were followed until 3 years.ResultsThe mean age of the study group was 49.90 ± 1.66. The mean fibroid size reduced from 15.05 ± 57.20 cm to 13.56 ± 39.39 cm (P = 0.012) and fibroid volume reduced from 72.78 ± 110.6 to 50.96 ± 64.2 (P = 0.116). There was no signification changes in the serum level of hormones at the end of six months. Eight cases were menopause at the end of the study and hypoestrogenism symptoms did not happened in none of the cases until the end of 24 months. Except in one case, there was no need to do surgery on others.ConclusionsCombination of Diphereline + Letrozole probably could prevent surgery in cases that have multiple fibroids, perimenopause, anemic and candidate for surgery.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%