Traitements intrapéritonéaux de la carcinose ovarienne : proposition d’algorithmes décisionnels

Abstract

Intraperitoneal therapy for carcinomatosis in ovarian cancer: proposed treatment algorithmOvarian cancer is the first cause of death by gynecological cancer. Most of the patients are diagnosed with peritoneal carcinomatosis that represents a therapeutic challenge. Its management implies maximal cytoreductive surgery with survival benefit. Over the last three decades, several strategies of intra-peritoneal chemotherapy have been investigated. This includes intra-peritoneal adjuvant chemotherapy that is used mainly in North America, hyperthermic intraperitoneal chemotherapy (HIPEC) and more recently pressurized intraperitoneal aerosol chemotherapy (PIPAC). In the current article, we review the evidence in favor of each therapeutic approach, and we propose treatment algorithms depending on the clinical situation of ovarian cancer patients: upfront, platinum-sensitive and platinum-resistant relapse.

Descriptive review of current practices and prognostic factors in patients with ovarian cancer treated by pressurized intraperitoneal aerosol chemotherapy (PIPAC): a multicentric, retrospective, cohort of 234 patients

“…There is a lack of literature yet proposing a decision algorithm for PIPAC management for patients with OC (29). The additional analyses allowed us to highlight some trends of longer OS and PFS, in favor of the subgroup having performed three or more PIPACs.…”