Traitement préventif et curatif local de l'infection à virus rabique fixe (C.V.S.) chez la souris par des alcaloïdes (colchicine et vinblastine) inhibiteurs du flux axoplasmique

Heaney, Thomas; Bijlenga, G.; Joubert, Louis

doi:10.1016/s0399-077x(76)80094-7

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B Voles De Pdn~tration Des Virus Clans Le Systdme Nerveux1

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1978

1995

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Cited by 6 publications

(2 citation statements)

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“…Le cas o~ la vole nerveuse est peut-~tre la plus exclusive est la rage. Heaney et Biljenga ont montr6 que ce virus, dans un syst6me exp6rimental utilisant la souris, empruntait tout sirnplement le flux axonal, en bloquant celui-ci avec de la colchicine (15). Hurst a d'autre part montr6 que l'infection des cellules de Schwann contamin6es de proche en proche pouvait ~tre la vole de p~n6tration d'un virus herp6tique animal (pseudo rage) (17).…”

Section: B Voles De Pdn~tration Des Virus Clans Le Systdme Nerveuxunclassified

Généralités sur l'infection du système nerveux par les virus

Cathala

1978

Revue d&'apos;Electroencéphalographie et de Neurophysiologi

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Section: B Voles De Pdn~tration Des Virus Clans Le Systdme Nerveuxunclassified

Généralités sur l'infection du système nerveux par les virus

Cathala

1978

Revue d&'apos;Electroencéphalographie et de Neurophysiologi

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“…In previous experiments (Heaney et al 1976) we showed that a saturated solution of colchicine applied 3 days before intraplantar infection with the CVS strain of rabies virus was the most effective in arresting the infection. A saturated solution of colchicine has a concentration of I I5 mM.…”

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confidence: 94%

Post-Exposure Local Treatment of Mice Infected with Rabies with Two Axonal Flow Inhibitors, Colchicine and Vinblastine

Bijlenga

Heaney

1978

Journal of General Virology

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SUMMARYPost-exposure protection of rabies-infected mice was observed by proximal application of axonal flow inhibitors, particularly vinblastine, to the local nerve(s). These observations indicate that rabies virus is transported by the axonal flow of the peripheral nerves to the central nervous system, Both a fixed virus (CVS) and a street (sylvatic) virus were used.This model in mice could be used to develop an additional post-exposure local treatment of rabies infection in man, by infiltrating local nerves or ganglions with axonal flow inhibitors, with the advantage that it would not interfere with subsequent vaccination as is the case with the administration of hyperimmune serum or immunoglobulin.

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The Pathogenesis of Rabies

Charlton¹

1988

Developments in Veterinary Virology

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Traitement préventif et curatif local de l'infection à virus rabique fixe (C.V.S.) chez la souris par des alcaloïdes (colchicine et vinblastine) inhibiteurs du flux axoplasmique

Cited by 6 publications

References 28 publications

Généralités sur l'infection du système nerveux par les virus

Généralités sur l'infection du système nerveux par les virus

Post-Exposure Local Treatment of Mice Infected with Rabies with Two Axonal Flow Inhibitors, Colchicine and Vinblastine

The Pathogenesis of Rabies

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