Traitement minute de la méningite cérébro-spinale épidémique par injection intramusculaire unique de chloramphénicol (suspension huileuse)

Ceftriaxone as effective as long-acting chloramphenicol in short-course treatment of meningococcal meningitis during epidemics: a randomised non-inferiority study

“…Previous studies have shown similar CFR and recovery rates without sequelae at 72 h to those in our study. 5,13,14,22,23 All deaths reported in our study took place within 30 h of admission, and all occurred in patients who presented with impaired consciousness at admission. Furthermore, two-thirds of the patients who died had been diagnosed with another infection, either alone or associated with meningococcal meningitis.…”

“…Long-acting chloramphenicol (oily suspension) was first proven effective against epidemic meningococcal meningitis in the mid-1970s, 5,6 and has been recommended by WHO as a regimen of one or two intramuscular injections since 1995· 7 Even though oily chloramphenicol remains active against N meningitidis serogroup A 8 and is critical for the management of meningitis epidemics, continuation of the production of the drug is uncertain, mainly because of the absence of financial market perspectives for this product. 9 Alternative antimicrobial drugs with proven efficacy against N meningitidis include intravenous benzylpenicillin, ampicillin, and intravenous or intramuscular chloramphenicol or ceftriaxone.…”