Traitement durable des lipoatrophies faciales VIH et autres par implants malaires SAM GoreTex® et hydrogel de polyacrylamide (Eutrophill®). À propos de 90 cas consécutifs

Background and Aim: Osmotically active tissue expanders allow the harvesting of soft tissue for reconstruction after different injuries. However, their expansion properties could be improved. Thus, our goal was to examine the in vivo applicability of acrylamide (AAm), acrylic acid (AAc) and N- isopropylacrylamide (NIPAAm) hydrogels. Materials and Methods: Cylinders of AAm, AAc and NIPAAm hydrogels were implanted under the skin of rats in the dorsal region. The diameter and the length of the cylinders were measured daily. After removal of the hydrogels, their mass and rheological properties were determined. Further, biopsies were taken from the adjacent tissue for histological analysis. Results: The hydrogels reached the peak of swelling by the end of the 2nd postoperative week. The wet mass of the removed cylinders was 25 times their dry mass prior to implantation. NIPAAm polymers exhibited the most favourable visco-elastic properties, with the highest tendency to retain their preformed shape. The histological analysis revealed serious tissue damage when the AAc devices were used, whereas the AAm and NIPAAm did not result in such lesions. Conclusion: In view of its mechanical and biological properties, NIPAAm hydrogel seems to be the most appropriate of these materials for application in plastic and reconstructive surgery.

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Traitement durable des lipoatrophies faciales VIH et autres par implants malaires SAM GoreTex® et hydrogel de polyacrylamide (Eutrophill®). À propos de 90 cas consécutifs

Cited by 4 publications

References 14 publications

Medical and Surgical Applications of Expanded PTFE

Medical and Surgical Applications of Expanded PTFE

Assessing the Long-Term Viability of Facial Fat Grafts: An Objective Measure Using Computed Tomography

Acrylamide, Acrylic Acid and N-Isopropylacrylamide Hydrogels as Osmotic Tissue Expanders

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