Traitement de la bilharziose intestinale. Evaluation de l'oxamniquine à partir de 172 observations

Gentilini, M; Danis, M.; Petit, P; Meunier, Yann A.; Brücker, Gilles; Vernant-Neisson, C.; Arnaud, J.

doi:10.1016/s0399-077x(81)80028-5

Cited by 2 publications

(1 citation statement)

References 8 publications

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“…En 1981, la mise sur le marché de l'oxamniquine (Vansil ® ) a radicalement changé la prise en charge des patients. Cet antiparasitaire était prescrit en une seule prise (15mg/kg) avec une efficacité et une tolérance remarquable (Gentilini et al, 1981). Il est certain que ce médicament a permis une diminution rapide du nombre de porteurs de S. mansoni en améliorant la compliance des patients.…”

Section: Dépistage Parasitologique Et éValuation De L'efficacité Des unclassified

Le contrôle de la schistosome intestinale de l'île de la Martinique

Schlegel¹,

Pointier

Petitjean-Roget

et al. 1997

Parasite

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Summary : THE CONTROL OF INTESTINAL SCHISTOSOMIASIS FROM MARTINIQUE ISLANDThe presence of schistosomiasis mansoni is known in Martinique since the beginning of the XXth century. A general survey of the distribution of the disease was carried out in 1977 and showed a mean prevalence of 12 % (coprology and serology taken together) in the whole of the island. Following this survey, an integrated control programme associating sanitary education, detection and treatment of patients and improved sanitation, was developed. In addition, a biological control programme against the intermediate snail host, Biomphalaria glabrata using the competitor snail, Melanoides tuberculata, was developed in the transmission sites. The decline of snail populations and of its parasite, as well as a strong reduction of the prevalence in humans were recorded between 1977 and 1996. At the present time, only few cases corresponding to older infections are detected. This epidemiological situation is quite different from that in Guadeloupe island where, in spite of an excellent control programme which was achieved on the Basse-Terre district, an important focus is still functionning on Grande-Terre district with the black rat as host reservoir. Such foci do not exist on Martinique island.

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Section: Dépistage Parasitologique Et éValuation De L'efficacité Des unclassified

Le contrôle de la schistosome intestinale de l'île de la Martinique

Schlegel¹,

Pointier

Petitjean-Roget

et al. 1997

Parasite

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Field trials of praziquantel and oxamniquine for the treatment of schistosomiasis mansoni in Burundi

Gryseels

Nkulikyinka

Coosemans

1987

Transactions of the Royal Society of Tropical Medicine and Hygi

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Praziquantel and oxamniquine were evaluated under operational conditions for use in mass-treatment campaigns in the Rusizi Plain, Burundi. After 6 weeks, the cure rates for oxamniquine at 20, 30 and 40 mg/kg in children (less than 20 years) were respectively 47%, 67% and 86%; in adults they were 86%, 97% and 97%. The egg reduction rates were over 98% in all groups. For praziquantel at 20, 30 and 40 mg/kg the cure rates in children were respectively 58%, 63% and 78%; in adults, 55%, 87% and 91%. The egg reduction rates were respectively 92%, 96%, 98% and 91%, 98%, 98%. These results were largely confirmed by a follow-up 3 months after treatment. Oxamniquine frequently caused important dizziness and drowsiness, and in 2 cases epileptiform seizures. The side effects of praziquantel were mainly mild transient colics and diarrhoea. The cost of oxamniquine (in Burundi) was twice to three times the cost of praziquantel. Because of its better acceptability and its lower cost, with only slightly less good parasitological results, praziquantel, at 40 mg/kg in a single dose, has been selected as the drug of choice for mass-treatment campaigns in Burundi.

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Traitement de la bilharziose intestinale. Evaluation de l'oxamniquine à partir de 172 observations

Cited by 2 publications

References 8 publications

Le contrôle de la schistosome intestinale de l'île de la Martinique

Le contrôle de la schistosome intestinale de l'île de la Martinique

Field trials of praziquantel and oxamniquine for the treatment of schistosomiasis mansoni in Burundi

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