Trait Variation in American Marsupials Based on Biological Rules

Cáceres, Nilton C.; Brum, Mariana N.; Battistella, Thaís; Bubadué, Jamile

doi:10.1007/978-3-030-88800-8_11-1

Cited by 1 publication

(1 citation statement)

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“…In contrast, marsupials are found only in Australasia and the Americas, and feature development that is characterized by short gestation and relatively extended lactation [19]. While marsupials vary greatly in terms of both fur pigmentation and pattern, they are considered to follow ecogeographic and evolutionary rules and biological trends for fur trait variation like eutherian mammals [20]. Despite this, marsupials are largely unstudied from the perspective of fur genetics.…”

Section: Introductionmentioning

confidence: 99%

Coat colour in marsupials: genetic variants at the ASIP locus determine grey and black fur of the brushtail possum

Bond,

Veale,

Alexander

et al. 2024

R. Soc. Open Sci.

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The possession of fur or hair is a defining characteristic of mammals and can occur in a variety of colours and patterns. While genetic determinants of coat colour are well described in eutherian ‘placental’ mammals, the other major mammalian infraclass, marsupials, is grossly understudied. The fur of the common brushtail possum ( Trichosurus vulpecula ), an iconic native mammal found throughout Australia and introduced into Aotearoa New Zealand, possesses two main colour morphs: grey and black. To identify genetic variants associated with coat colour, we performed a genome-wide association study (GWAS) with genotype by sequencing (GBS) data. Single nucleotide variants (SNVs) on chromosome 3, close to the agouti signalling protein ( ASIP ) gene that controls the temporal and spatial distribution of pigments in eutherian mammals, were identified. Fine-mapping identified a C>T variant at chr3:100483705 that results in a ASIP:p.Arg115Cys missense substitution, and animals homozygous for this variant have black fur. In addition to uncovering the first genetic determinant of coat colour in a natural marsupial population, comparative analysis of ASIP in divergent marsupial species identified the dasyurids as having accelerated evolution, reflecting their well described diversity of coat colour and pattern.

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Section: Introductionmentioning

confidence: 99%