2024
DOI: 10.1093/genetics/iyae148
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Trait imputation enhances nonlinear genetic prediction for some traits

Ruoyu He,
Jinwen Fu,
Jingchen Ren
et al.

Abstract: The expansive collection of genetic and phenotypic data within biobanks offers an unprecedented opportunity for biomedical research. However, the frequent occurrence of missing phenotypes presents a significant barrier to fully leveraging this potential. In our target application, on one hand, we have only a small and complete dataset with both genotypes and phenotypes to build a genetic prediction model, commonly called a polygenic (risk) score (PGS or PRS); on the other hand, we have a large dataset of genot… Show more

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