Technology management is a key issue for innovation and quality in health care sector, which, in turn, implies effectiveness and safety considerations. It is valuable, to explore the influence of technology to safety management and quality in health environment, and so to dig into what topics arise from this relationship. The purpose of this study is to explore the relevance of Health Technology Management to safety and quality in health organizations from health professional’s perceptions and scientific evolution perspectives. Methodology and Theoretical Orientation: An exploratory based qualitative study was conducted. A semi-structured interview was administered to health professionals with professional and academic experience in clinical settings in Matanzas territory. There were selected the main issues raised from professional’s opinions. Additionally, there was examined the scientific development of this subject by means of a review of research documents published in Sciencedirect and Scielo databases. Findings: Main views were similar as to technology use, assessment and innovation impact on human errors, how they may condition clinical and therapeutic practices, health recovery as well as a risky care environment for patients and personnel. Conclusion & Significance: It is confirmed the importance of health technology management to safety and quality of health care as well as research.