“…Most of these interventions did not significantly reduce caregivers' strain or improve their well-being (Grasel et al, 2005; Larson et al, 2005; Tilling et al, 2005; Björkdahl et al, 2007; Johnston et al, 2007; Bakas et al, 2009, 2015; Forster et al, 2009, 2013; Pierce et al, 2009; Eames et al, 2013; Bishop et al, 2014; Hirsch et al, 2014; Ostwald et al, 2014; Cameron et al, 2015; Robinson-Smith et al, 2016). However, some studies yielded significant results in improving stroke knowledge (Louie et al, 2006; Franzén-Dahlin et al, 2008) and eventually reducing general burden, without any significant result in main psychological outcomes, such as anxiety and depression (Burton and Gibbon, 2005; Oupra et al, 2010; Perrin et al, 2010; Kim et al, 2012; Araujo et al, 2018; Cheng et al, 2018; Mores et al, 2018). Only in one study nurse counseling lowered anxiety symptoms but not the depressive ones (Goudarzian et al, 2018).…”