Training-induced prefrontal neuronal changes transfer between tasks

Tang, Hua; Riley, Mitchell R.; Singh, Balbir Singh Mahinder; Qi, Xue-Lian; Blake, David T.; Constantinidis, Christos

doi:10.1101/2020.10.22.351197

Cited by 3 publications

(3 citation statements)

References 63 publications

(86 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The SFG plays an essential role in memory and higher-order cognitive processing, particularly in working memory (Briggs et al, 2020). The OFC is a core brain region correlated with episodic memory (Rolls et al, 2022;Tang et al, 2022;Wang et al, 2023). These brain alterations were found to expand with age in the present study, suggesting that chronic pain may lead to earlier functional and structural decline in the OFC and SFG, thereby potentially impairing pain processing and memory function.…”

Section: Discussionsupporting

confidence: 48%

Changes in brain structure and function during early aging in patients with chronic low back pain

Zu,

Zhang,

Hao

et al. 2024

Front. Aging Neurosci.

View full text Add to dashboard Cite

ObjectiveTo explore the structural and functional changes in cognition-related brain regions in patients with chronic low back pain (CLBP) at earlier ages, and explore the impact of the interaction between CLBP and age on the brain.MethodsSeventy-six patients with CLBP were recruited and divided into “younger” age group (20–29 years, YA), “middle” age group (30–39 years, MA), and “older” age group (40–49 years, OA). All patients underwent functional magnetic resonance imaging (fMRI) as well as clinical psychological and pain-related symptoms assessments.ResultsStructural analysis showed that patients in OA group had lower gray matter (GM) volumes in the orbitofrontal cortex (OFC) bilaterally and the right superior frontal gyrus (SFG) compared to YA group. The resting-state brain activity analysis showed that amplitude of low-frequency fluctuation (ALFF) values in the bilateral postcentral gyrus and left ventral medial prefrontal cortex (mPFC) were significantly different in the OA group. The functional connectivity (FC) in the right ventral dorsolateral prefrontal cortex (DLPFC) and the right insula was significantly decreased in the OA group compared to the YA and MA groups. Likewise, the FC in the left caudal parahippocampal gyrus (PHG) and left inferior parietal lobule (IPL) were significantly lower in the MA and OA groups compared to the YA group. In addition, both the structural properties and the FC values of these brain regions were significantly correlated with age.ConclusionThis preliminary study concludes that CLBP affects the aging process. The synergistic effects of CLBP and aging accelerate the functional and structural decline of certain areas of the brain, which not only affects pain processing, but are also may be associated with cognitive declines.

show abstract

Section: Discussionsupporting

confidence: 48%

Changes in brain structure and function during early aging in patients with chronic low back pain

Zu,

Zhang,

Hao

et al. 2024

Front. Aging Neurosci.

View full text Add to dashboard Cite

show abstract

“…Mante et al (2013) reported that the prefrontal cortex is a dynamic system where context-dependent selectivity for relevant stimulus component is implemented by separate neuronal populations. Particularly relevant to this issue is the discovery that, after training on various tasks, prefrontal neurons showed decreased trial-to-trial variability of discharges and noise correlation between neurons so that new information is incorporated into the activity of a small population of neurons (Qi and Constantinidis, 2013;Tang et al, 2022). In most of these studies, neurons were recorded from the lPFC, while we recorded from the medial frontal area.…”

Section: Discussionmentioning

confidence: 99%

Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex

Awan

Mushiake²,

Matsuzaka³

2023

Front. Syst. Neurosci.

View full text Add to dashboard Cite

Higher mammals are able to simultaneously learn and perform a wide array of complex behaviors, which raises questions about how the neural representations of multiple tasks coexist within the same neural network. Do neurons play invariant roles across different tasks? Alternatively, do the same neurons play different roles in different tasks? To address these questions, we examined neuronal activity in the posterior medial prefrontal cortex of primates while they were performing two versions of arm-reaching tasks that required the selection of multiple behavioral tactics (i.e., the internal protocol of action selection), a critical requirement for the activation of this area. During the performance of these tasks, neurons in the pmPFC exhibited selective activity for the tactics, visuospatial information, action, or their combination. Surprisingly, in 82% of the tactics-selective neurons, the selective activity appeared in a particular task but not in both. Such task-specific neuronal representation appeared in 72% of the action-selective neurons. In addition, 95% of the neurons representing visuospatial information showed such activity exclusively in one task but not in both. Our findings indicate that the same neurons can play different roles across different tasks even though the tasks require common information, supporting the latter hypothesis.

show abstract

“…It is plausible that pretrained monkeys may reuse strategies acquired for performing the discrimination task while learning the DMC task. Similarly, different training histories may lead to different behavioral strategies to perform the DMC task, and different strategies may give rise to different patterns of activity in LIP (Tang et al, 2020). Previous studies have found that stimulus encoding and working-memory dependent sustained-firing activity in the prefrontal cortex during cognitive tasks depends on training (Qi & Constantinidis, 2013;Li et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Low-dimensional encoding of decisions in parietal cortex reflects long-term training history

Latimer

Freedman

2021

Preprint

View full text Add to dashboard Cite

Neurons in parietal cortex exhibit task-related activity during decision-making tasks. However, it remains unclear how long-term training to perform different tasks over months or even years shapes neural computations and representations. We examine lateral intraparietal area (LIP) responses during a visual motion delayed-match-to-category (DMC) task. We consider two pairs of monkeys with different training histories: one trained only on the DMC task, and another first trained to perform fine motion-direction discrimination. We introduce generalized multilinear models to quantify low-dimensional, task-relevant components in population activity. During the DMC task, we found stronger cosine-like motion-direction tuning in the pretrained monkeys than in the DMC-only monkeys, and that the pretrained monkeys' performance depended more heavily on sample-test stimulus similarity. These results suggest that sensory representations in LIP depend on the sequence of tasks that the animals have learned, underscoring the importance of training history in studies with complex behavioral tasks.

show abstract

Training-induced prefrontal neuronal changes transfer between tasks

Cited by 3 publications

References 63 publications

Changes in brain structure and function during early aging in patients with chronic low back pain

Changes in brain structure and function during early aging in patients with chronic low back pain

Non-overlapping sets of neurons encode behavioral response determinants across different tasks in the posterior medial prefrontal cortex

Low-dimensional encoding of decisions in parietal cortex reflects long-term training history

Contact Info

Product

Resources

About