Training-induced hypoalgesia and its potential underlying mechanisms

Song, Jun; Yamada, Yujiro; Kataoka, Ryo; Wong, Vickie; Spitz, Robert W.; Bell, Zachary W.; Loenneke, Jeremy P.

doi:10.1016/j.neubiorev.2022.104858

Cited by 13 publications

(10 citation statements)

References 130 publications

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“…A 30-second rest was incorporated between each set with the cuff in the BFR condition still inflated. At the end of each set, with the cuff inflated, participants immediately reported their exertion level based on the Borg scale (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) and rated perceptual discomfort on a 10-point scale [18,26]. The overall exertion level for each condition was quantified as the mean of four RPE values for each set, consistent with previous studies [14,27].…”

Section: Resistance Exercise Protocolsmentioning

confidence: 95%

“…Evidence is also mixed regarding the extent of systemic EIH, i.e. EIH in the contralateral non-exercised limb [5,17]. Song et al (2022b) found no significant difference in systemic EIH between conditions (30%1RM with and without BFR at 80% LOP) in a knee extension exercise [16].…”

Section: Introductionmentioning

confidence: 99%

“…Summary of mean (SD) ratings of perceived exertion (RPE) and discomfort at the end Perceived exertion level were measured by the Rate of Perceived Exertion scale(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20), with a higher score indicate a greater exertion level. Participant's discomfort level were measured on a 10-point scale, with higher score indicates greater discomfort level.…”

mentioning

confidence: 99%

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Hypoalgesia and Conditioned Pain Modulation in Blood Flow Restriction Resistance Exercise

Yang,

Rolnick,

Merriwether

et al. 2024

Int J Sports Med

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We compared the magnitude of exercise-induced hypoalgesia and conditioned pain modulation between blood-flow restriction (BFR) resistance exercise (RE) and moderate-intensity RE. Twenty-five asymptomatic participants performed unilateral leg press in two visits. For moderate-intensity RE, subjects exercised at 50% 1RM without BFR whereas BFR RE exercised at 30% 1RM with a cuff inflated to 60% limb occlusion pressure. Exercise-induced hypoalgesia was quantified by pressure pain threshold changes before and after RE. Conditioned pain modulation was tested using cold water as the conditioning stimulus and mechanical pressure as the test stimulus and quantified as pressure pain threshold change. Difference in conditioned pain modulation pre- to post- RE was then calculated. The differences of RE on pain modulations were compared using paired t-tests. Pearson’s r was used to examine the correlation between exercise-induced hypoalgesia and changes in conditioned pain modulation. We found greater hypoalgesia with BFR RE compared to moderate-intensity RE (p = 0.008). Significant moderate correlations were found between exercise-induced hypoalgesia and changes in conditioned pain modulation (BFR: r = 0.63, moderate-intensity: r = 0.72). BFR RE has favorable effects on pain modulation in healthy adults and the magnitude of exercise-induced hypoalgesia is positively correlated with conditioned pain modulation activation.

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Section: Resistance Exercise Protocolsmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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Hypoalgesia and Conditioned Pain Modulation in Blood Flow Restriction Resistance Exercise

Yang,

Rolnick,

Merriwether

et al. 2024

Int J Sports Med

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“…Virtual reality exercise is likely to promote effects similar to those of traditional exercise [ 118 ]. Exercise-induced hypoalgesia (EIH), which has been defined as a generalized reduction in pain and pain sensitivity that occurs during exercise and for some time afterward, may also be mediated by the immune, pain modulation systems (opioid/serotonergic), and mesocorticolimbic systems [ 119 , 120 , 121 ]. Preliminary evidence on active virtual reality EIH shows an added hypoalgesic effect in a healthy population [ 122 , 123 , 124 ].…”

Section: Immersive Virtual Reality As a Medium For Altering Sensorimo...mentioning

confidence: 99%

Role of Immersive Virtual Reality in Motor Behaviour Decision-Making in Chronic Pain Patients

et al. 2023

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Primary chronic pain is a major contributor to disability worldwide, with an estimated prevalence of 20–33% of the world’s population. The high socio-economic impact of musculoskeletal pain justifies seeking an appropriate therapeutic strategy. Immersive virtual reality (VR) has been proposed as a first-line intervention for chronic musculoskeletal pain. However, the growing literature has not been accompanied by substantial progress in understanding how VR exerts its impact on the pain experience and what neurophysiological mechanisms might be involved in the clinical effectiveness of virtual reality interventions in chronic pain patients. The aim of this review is: (i) to establish the state of the art on the effects of VR on patients with chronic pain; (ii) to identify neuroplastic changes associated with chronic pain that may be targeted by VR intervention; and (iii) to propose a hypothesis on how immersive virtual reality could modify motor behavioral decision-making through an interactive experience in patients with chronic pain.

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“…Clinical studies have shown that exercise is effective in improving arthritis, fibromyalgia, low back pain, intermittent claudication, neck pain, and knee osteoarthritis. [2][3][4][5][6] Mechanistic studies have confirmed that exercise can relieve pain symptoms by increasing endogenous opioids, promoting the recovery of neurotrophic factors, activating serotonin (5-HT) receptors, modulating inflammatory factors, and enhancing pain line inhibition. [7][8][9][10] Exploring the protective effect of exercise on NP and the specific molecular mechanisms involved is of great significance; however, limited studies have evaluated the role of treadmill training for alleviate NP.In recent years, tandem mass tagging (TMT) technology has been widely used in proteomics studies owing to its high precision, stability, and throughput.…”

Section: Introductionmentioning

confidence: 99%

Proteomic Analysis of the Spinal Dorsal Horn in Mice with Neuropathic Pain After Exercise

Bai¹,

Zhang²,

Zhou³

et al. 2023

JPR

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Purpose Neuropathic pain (NP) is a chronic pain state with a complex etiology that currently lacks effective treatment in clinical practice. Studies have found that exercise training can alleviate NP hyperalgesia, but the specific mechanism remains unclear. Here, we sought to identify proteins and signaling pathways critical for mediating the effects of treadmill training on NP in a mouse model of spared nerve injury (SNI). Methods We used Tandem Mass Tag (TMT) technology for proteins and signaling pathways identification. Functional enrichment analyses were conducted using DAVID and Metascape software. Ingenuity pathway analysis was used to conduct functional annotation and analyze alterations in canonical pathways and molecular networks. Reverse transcription quantitative PCR (RT-qPCR) was used to confirm the results of proteomics analysis. Results A total of 270 differentially expressed proteins were screened in the detrained and trained groups ( P ≤0.05). Enrichment and ingenuity pathway analysis revealed the effects of treadmill training on autophagy, cAMP-mediated signaling, calcium signaling and NP signaling in dorsal horn nerves. Treadmill training reduced the expression of Akt3, Atf2, Gsk3b, Pik3c3, Ppp2ca , and Sqstm1 , and increased the expression of Pik3cb in the autophagic pathway. Conclusion Our results suggest that treadmill training may alleviate nociceptive hyperalgesia in NP mice by modulating the autophagic pathway, providing unique mechanistic insights into the analgesic effects of exercise.

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Training-induced hypoalgesia and its potential underlying mechanisms

Cited by 13 publications

References 130 publications

Hypoalgesia and Conditioned Pain Modulation in Blood Flow Restriction Resistance Exercise

Hypoalgesia and Conditioned Pain Modulation in Blood Flow Restriction Resistance Exercise

Role of Immersive Virtual Reality in Motor Behaviour Decision-Making in Chronic Pain Patients

Proteomic Analysis of the Spinal Dorsal Horn in Mice with Neuropathic Pain After Exercise

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