Training gains and transfer effects after mnemonic strategy training in mild cognitive impairment: A fMRI study

Simon, Sharon Sanz; Hampstead, Benjamin M.; Nucci, Mariana Penteado; Duran, Fabio; Fonseca, Luciana Mascarenhas; Martin, Maria da Graça Morais; Ávila, Renata; Porto, Fábio Henrique de Gobbi; Brucki, Sônia Maria Dozzi; Martins, Camila Bertini; Tascone, Lyssandra S.; Amaro, Edson; Busatto, Geraldo F.; Bottino, Cássio M.C.

doi:10.1016/j.ijpsycho.2019.03.014

Cited by 13 publications

(21 citation statements)

References 79 publications

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“…These patterns may reflect a difference in approach taken by APOE4 carriers and non-carriers to complete the task. For example, mnemonic strategy training appears to improve performance on face-name associative memory tasks and further correlate with increased frontoparietal activity in older adults with amnesic mild cognitive impairment [89,90]. We did not assess strategy use in the present study and were therefore unable to test this possibility directly.…”

Section: Apoe4-based Differences In Brain-behavior Correlationsmentioning

confidence: 86%

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

Rabipour

Rajagopal

et al. 2020

JAD

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Background: Episodic memory decline is one of the earliest symptoms of late-onset Alzheimer's disease (AD). Older adults with the apolipoprotein E 4 (+APOE4) genetic risk factor for AD may exhibit altered patterns of memory-related brain activity years prior to initial symptom onset. Objective: Here we report the baseline episodic memory task functional MRI results from the PRe-symptomatic EValuation of Experimental or Novel Treatments for Alzheimer's Disease cohort in Montreal, Canada, in which 327 healthy older adults were scanned within 15 years of their parent's conversion to AD.

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Section: Apoe4-based Differences In Brain-behavior Correlationsmentioning

confidence: 86%

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

Rabipour

Rajagopal

et al. 2020

JAD

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“…There is a significant body of literature on functional activity and connectivity changes after strategy-based CT that show similar findings as the results from this review. For instance, mnemonic strategy CTs increased activity of fronto-parietal and temporal regions in individuals suffering from MCI and increased functional connectivity within cognitive networks in healthy elderly (Chapman et al, 2015;Chapman, Spence, Aslan, & Keebler, 2017;Hampstead, Stringer, Stilla, Giddens, & Sathian, 2012;Hampstead, Stringer, Stilla, & Sathian, 2019;Simon et al, 2019). These studies were, however, beyond the scope of this review.…”

Section: Limitations and Recommendations For Future Researchmentioning

confidence: 91%

The Effects of Cognitive Training on Brain Network Activity and Connectivity in Aging and Neurodegenerative Diseases: a Systematic Review

et al. 2020

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Cognitive training (CT) is an increasingly popular, non-pharmacological intervention for improving cognitive functioning in neurodegenerative diseases and healthy aging. Although meta-analyses support the efficacy of CT in improving cognitive functioning, the neural mechanisms underlying the effects of CT are still unclear. We performed a systematic review of literature in the PubMed, Embase and PsycINFO databases on controlled CT trials (N > 20) in aging and neurodegenerative diseases with pre-and post-training functional MRI outcomes up to November 23rd 2018 (PROSPERO registration number CRD42019103662). Twenty articles were eligible for our systematic review. We distinguished between multi-domain and single-domain CT. CT induced both increases and decreases in task-related functional activation, possibly indicative of an inverted U-shaped curve association between regional brain activity and task performance. Functional connectivity within 'cognitive' brain networks was consistently reported to increase after CT while a minority of studies additionally reported increased segregation of frontoparietal and default mode brain networks. Although we acknowledge the large heterogeneity in type of CT, imaging methodology, in-scanner task paradigm and analysis methods between studies, we propose a working model of the effects of CT on brain activity and connectivity in the context of current knowledge on compensatory mechanisms that are associated with aging and neurodegenerative diseases.

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“…For example, using passive methods (e.g., repeat of the names as a distraction during the retention interval) can help prime memory retrieval of face-name associations [2]. Other studies have also demonstrated that mnemonic training can help to improve face-name memory function [7,25,30].…”

Section: Introductionmentioning

confidence: 99%

The Effects of High-Intensity Acute Exercise on Face-Name Memory in Healthy Young Adults

Gilbert

Loprinzi

2021

J. of SCI. IN SPORT AND EXERCISE

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The majority of previous research evaluating the effects of acute exercise on episodic memory function have focused on explicit memory tasks involving word-list paradigms. For a more real-world application, the present experiment evaluates whether high-intensity acute exercise can improve episodic memory function of incidentally processed information as well as increase one's ability to remember names associated with faces (face-name paradigm). A two-arm, parallel-group, randomized controlled intervention was employed. Participants (N = 91; M age = 20 years) were randomized into one of two groups, including an experimental group and a control group. The experimental group exercised for 20 min on a treadmill at a high-intensity (75% of heart rate reserve), while the control group engaged in a seated, time-matched task. Explicit memory was assessed from an intentional processing face-name paradigm in which participants encoded and subsequently recalled names that were paired with faces. Episodic memory for incidentally processed information was evaluated with a computerized program involving spatial-temporal integration. The mean (SD) number of correctly recalled face-name pairs between the exercise and control groups, respectively, for immediate memory were 11.16 (4.4) and 9.79 (4.3), P > 0.05. Results were similar for incidentally processed information, in that there were no differences between the exercise [7.30 (1.7)] and control [7.52 (1.9)] groups, P > 0.05. Overall, we did not observe evidence that high-intensity acute exercise improves episodic memory for incidentally or intentionally processed information.

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Training gains and transfer effects after mnemonic strategy training in mild cognitive impairment: A fMRI study

Cited by 13 publications

References 79 publications

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

APOE4 Status is Related to Differences in Memory-Related Brain Function in Asymptomatic Older Adults with Family History of Alzheimer’s Disease: Baseline Analysis of the PREVENT-AD Task Functional MRI Dataset

The Effects of Cognitive Training on Brain Network Activity and Connectivity in Aging and Neurodegenerative Diseases: a Systematic Review

The Effects of High-Intensity Acute Exercise on Face-Name Memory in Healthy Young Adults

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