Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy

Eljaszewicz, Andrzej; Ruchti, Fiorella; Radzikowska, Urszula; Głobińska, Anna; Boonpiyathad, Tadech; Gschwend, Anna; Morita, Hideaki; Helbling, Arthur; Arasi, Stefania; Kahlert, Helga; Berek, Nadine; Nandy, Andreas; Akdiş, Mübeccel; Willers, Christoph; Moniuszko, Marcin; Sokołowska, Milena

doi:10.1016/j.jaci.2020.08.042

Cited by 72 publications

(83 citation statements)

References 72 publications

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“…In fact, allergen-specific immunotherapy modifies the composition and heterogeneity of ILCs, among other innate immune cells, and brings them to the level found in healthy individuals. [ 95 ]…”

Section: Type 2 Ilcsmentioning

confidence: 99%

Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease

Saéz

Gómez-Bris

Herrero‐Fernández

et al. 2021

IJMS

103

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Inflammatory bowel disease (IBD) is a heterogeneous state of chronic intestinal inflammation of unknown cause encompassing Crohn’s disease (CD) and ulcerative colitis (UC). IBD has been linked to genetic and environmental factors, microbiota dysbiosis, exacerbated innate and adaptive immunity and epithelial intestinal barrier dysfunction. IBD is classically associated with gut accumulation of proinflammatory Th1 and Th17 cells accompanied by insufficient Treg numbers and Tr1 immune suppression. Inflammatory T cells guide innate cells to perpetuate a constant hypersensitivity to microbial antigens, tissue injury and chronic intestinal inflammation. Recent studies of intestinal mucosal homeostasis and IBD suggest involvement of innate lymphoid cells (ILCs). These lymphoid-origin cells are innate counterparts of T cells but lack the antigen receptors expressed on B and T cells. ILCs play important roles in the first line of antimicrobial defense and contribute to organ development, tissue protection and regeneration, and mucosal homeostasis by maintaining the balance between antipathogen immunity and commensal tolerance. Intestinal homeostasis requires strict regulation of the quantity and activity of local ILC subpopulations. Recent studies demonstrated that changes to ILCs during IBD contribute to disease development. A better understanding of ILC behavior in gastrointestinal homeostasis and inflammation will provide valuable insights into new approaches to IBD treatment. This review summarizes recent research into ILCs in intestinal homeostasis and the latest advances in the understanding of the role of ILCs in IBD, with particular emphasis on the interaction between microbiota and ILC populations and functions.

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Section: Type 2 Ilcsmentioning

confidence: 99%

Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease

Saéz

Gómez-Bris

Herrero‐Fernández

et al. 2021

IJMS

103

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“…Metabolic control in DCs and monocytes has also been linked to the epigenetic changes and subsequent phenomenon of “trained immunity” – a memory, induced in cells of innate immunity such as DCs and monocytes/macrophages ( 90 ). Importantly, this phenomenon has been suggested to play an important role in the induction of tolerance to allergens during allergen-specific immunotherapy (AIT) as tolerogenic plasmacytoid DCs, CD141 + myeloid DCs, and intermediate monocytes were increased after 1 year of therapy whereas pro-inflammatory CD1c + myeloid DCs and non-classical monocytes were reduced ( 91 ).…”

Section: Metabolic Regulation Of Antigen-presenting Cells: Macrophages and Dendritic Cellsmentioning

confidence: 99%

The Importance of Metabolism for Immune Homeostasis in Allergic Diseases

et al. 2021

Self Cite

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There is increasing evidence that the metabolic status of T cells and macrophages is associated with severe phenotypes of chronic inflammation, including allergic inflammation. Metabolic changes in immune cells have a crucial role in their inflammatory or regulatory responses. This notion is reinforced by metabolic diseases influencing global energy metabolism, such as diabetes or obesity, which are known risk factors of severity in inflammatory conditions, due to the metabolic-associated inflammation present in these patients. Since several metabolic pathways are closely tied to T cell and macrophage differentiation, a better understanding of metabolic alterations in immune disorders could help to restore and modulate immune cell functions. This link between energy metabolism and inflammation can be studied employing animal, human or cellular models. Analytical approaches rank from classic immunological studies to integrated analysis of metabolomics, transcriptomics, and proteomics. This review summarizes the main metabolic pathways of the cells involved in the allergic reaction with a focus on T cells and macrophages and describes different models and platforms of analysis used to study the immune system and its relationship with metabolism.

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“…The main mechanisms include early desensitization of effector cells and progressive onset of a regulatory B and T cell response [ 34 , 35 , 36 ]. Although the main changes of specific immunotherapy are antigen-specific, recent data support a beneficial effect in restoring the general balance of the immune system altered toward Th2 immune response [ 37 , 38 ]. A recent review analyzes the impact of the COVID-19 pandemic on the management of AIT in routine practice [ 39 ].…”

Section: Immune Responses In Aitmentioning

confidence: 99%

COVID-19 vaccination and allergen immunotherapy (AIT) - A position paper of the German Society for Applied Allergology (AeDA) and the German Society for Allergology and Clinical Immunology (DGAKI)

Klimek

Pfaar

Hamelmann

et al. 2021

ALS

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Background: Vaccinations against severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are intended to induce an immune response to protect against infection/disease. Allergen immunotherapy (AIT) is thought to induce a (different) immune response, e.g., to induce tolerance to allergens. In this position paper we clarify how to use AIT in temporal relation to COVID-19 vaccination. Four SARS-CoV-2 vaccines are currently approved in the EU, and their possible immunological interactions with AIT are described together with practical recommendations for use. Materials and methods: Based on the internationally published literature, this position paper provides specific recommendations for the use of AIT in temporal relation to a SARS-CoV-2 vaccination. Results: AIT is used in 1) allergic rhinitis, 2) allergic bronchial asthma, 3) insect venom allergy, 4) food allergy (peanut). Conclusion: For the continuation of an ongoing AIT, we recommend an interval of 1 week before and after vaccination for subcutaneous immunotherapy (SCIT). For sublingual immunotherapy (SLIT) and oral immunotherapy (OIT), we recommend taking them up to the day before vaccination and a break of 2 – 7 days after vaccination. Initiation of a new SCIT, SLIT, or OIT should be delayed until 1 week after the day of the second vaccination. For SCIT, we generally recommend an interval of ~ 1 week to COVID-19 vaccination.

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Trained immunity and tolerance in innate lymphoid cells, monocytes, and dendritic cells during allergen-specific immunotherapy

Cited by 72 publications

References 72 publications

Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease

Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease

The Importance of Metabolism for Immune Homeostasis in Allergic Diseases

COVID-19 vaccination and allergen immunotherapy (AIT) - A position paper of the German Society for Applied Allergology (AeDA) and the German Society for Allergology and Clinical Immunology (DGAKI)

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