Trained dogs can identify malignant solitary pulmonary nodules in exhaled gas

Guirao, Ángela; Molins, Laureano; Ramón, Irene Torres; Sunyer, G.; Viñolas, Núria; Marrades, Ramón M.; Sánchez, David; Fibla, Juan J.; Boada, Marc; Hernández, J; Guzmán, Rudith; Libreros, Alejandra; Gómez-Caro, Abel; Guerrero, Carlos; Agustí, Àlvar

doi:10.1016/j.lungcan.2019.06.008

Cited by 17 publications

(18 citation statements)

References 18 publications

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“…[100][101][102][103][104] A study specifically focusing on SPNs (30 patients, 79 controls) was presented at WCLC 2018 and showed a sensitivity of 97% and specificity of 99% (Table 2). 105 These results are similar to previously published studies which have included stage I-IV disease. [100][101][102][103][104] As dogs need to be trained individually and separately, and can have "off" days, bioengineered platforms are preferred.…”

Section: Breath-based Screeningsupporting

confidence: 91%

“…109 In 2018, several studies were presented or published on this topic and are also summarized in Table 2. 101,105,[110][111][112][113][114][115][116][117] With the exception of one study (de Vries et al 110 ), they all included patients with a suspicion of or proven lung cancer. The percentage of patients with early-stage disease varied between 12% and 79%.…”

Section: Breath-based Screeningmentioning

confidence: 99%

See 1 more Smart Citation

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

Balata

Fong

Hendriks

et al. 2019

Journal of Thoracic Oncology

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Lung cancer remains the leading cause of cancer-related mortality worldwide. Tobacco consumption remains the most important risk factor. Although the prevalence of smoking has decreased overall, it continues to be a significant burden for global health. It is estimated that there are still nearly 1 billion cigarette smokers worldwide. Prevention strategies have largely focused on tobacco control and prevention. However, we have witnessed a dramatic increase in the use of e-cigarettes and other vaping products. Primary chemoprevention has historically not been a successful strategy for lung cancer; however, focused approaches in specific groups of patients at high risk for development of lung cancer are underway. The majority of cases with NSCLC are diagnosed with locally advanced or metastatic disease, where the overall prognosis remains very poor. Early-stage NSCLC on the other hand has a much better prognosis and can usually be treated radically with either surgical resection or radical radiotherapy, with relatively favorable long-term outcomes. In addition to image-based screening, other methods such as breath-based and biofluidbased approaches are now being investigated for early detection of NSCLC. This review will focus on recent advancements in the field of prevention, screening, and early detection of NSCLC.

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Section: Breath-based Screeningsupporting

confidence: 91%

Section: Breath-based Screeningmentioning

confidence: 99%

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

Balata

Fong

Hendriks

et al. 2019

Journal of Thoracic Oncology

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“…The first clinical investigation of cancer was published by Willis (16) on bladder cancer in 2010, after having published a proof of principle study in 2004 (17). Several positive studies have been performed on colorectal cancer screening with odour material by canine scent detection (18,19), and some tendencies have been recorded for lung cancer (20,21,22,23), melanoma (24,25), prostate (26,27,28), or liver (29) cancers.…”

Section: B) Non Infectious Diseases Detection Dogsmentioning

confidence: 99%

Detection dogs as a help in the detection of COVID-19 Can the dog alert on COVID-19 positive persons by sniffing axillary sweat samples ? Proof-of-concept study

Grandjean

Sarkis²,

Tourtier³

et al. 2020

Preprint

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The aim of this study is to evaluate if the sweat produced by COVID-19 persons (SARS-CoV-2 PCR positive) has a different odour for trained detection dogs than the sweat produced by non COVID-19 persons. The study was conducted on 3 sites, following the same protocol procedures, and involved a total of 18 dogs. A total of 198 armpits sweat samples were obtained from different hospitals. For each involved dog, the acquisition of the specific odour of COVID-19 sweat samples required from one to four hours, with an amount of positive samples sniffing ranging from four to ten. For this proof of concept, we kept 8 dogs of the initial group (explosive detection dogs and colon cancer detection dogs), who performed a total of 368 trials, and will include the other dogs in our future studies as their adaptation to samples scenting takes more time.The percentages of success of the dogs to find the positive sample in a line containing several other negative samples or mocks (2 to 6) were 100p100 for 4 dogs, and respectively 83p100, 84p100, 90p100 and 94p100 for the others, all significantly different from the percentage of success that would be obtained by chance alone.We conclude that there is a very high evidence that the armpits sweat odour of COVID-19+ persons is different, and that dogs can detect a person infected by the SARS-CoV-2 virus.

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“…Avec des millions de récepteurs olfactifs dans leurs nez, les chiens sont l'une des espèces les plus efficaces pour détecter et rechercher des objets variés qui dégagent des odeurs spécifiques. Lorsqu'ils sont dressés, les chiens peuvent guider des personnes non voyantes (chiens guides), détecter des substances toxiques, rechercher des truffes, localiser des mines explosives ou des drogues, retrouver des personnes disparues et même détecter certains types de cancers 3,4 , etc.…”

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Ramassage écologique des déchets plastiques

Moustafa¹

2020

Preprint

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La pollution environnementale est un problème global qui réduit la qualité de vie dans de nombreuses régions dans le monde. Certaines grandes villes sont étouffées par des quantités importantes de micro- et macro déchets organiques et inorganiques, tels que des métaux lourds, des gaz à effet de serre, des déchets alimentaires, des déchets plastiques et des mégots de cigarette éparpillés ici et là. Ces derniers sont parmi les déchets les plus répandus sur terre. On les retrouve presque partout; dans les rues, les bords de routes, les terrasses des cafés, les gares routières, les plages, les parcs, etc. Chaque année, les municipalités dépensent des millions d'euros pour ramasser et traiter ces déchets. Des chiens dressés pour le ramassage des déchets plastiques peuvent contribuer à la bonne gestion de déchets de manière écologique et efficace.

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Trained dogs can identify malignant solitary pulmonary nodules in exhaled gas

Cited by 17 publications

References 18 publications

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

Prevention and Early Detection for NSCLC: Advances in Thoracic Oncology 2018

Detection dogs as a help in the detection of COVID-19 Can the dog alert on COVID-19 positive persons by sniffing axillary sweat samples ? Proof-of-concept study

Ramassage écologique des déchets plastiques

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