TRAIL-Mediated Apoptosis in Human Liver Chang Cells

Park, Channy; Hong, Sung Wook; Jin, Sung Ho; Kim, Nam Song; Cho, Kyung Ho; Cheon, Jin Ho; Ahn, Jae Yeon; Yang, Jung Ku; Park, Raekil

doi:10.4143/crt.2003.35.4.341

Cancer Res Treat

2003

DOI: 10.4143/crt.2003.35.4.341

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TRAIL-Mediated Apoptosis in Human Liver Chang Cells

Channy Park¹,

Sung Wook Hong²,

Sung Ho Jin³

et al.

Abstract: We suggested that TRAIL induces the apoptotic death of Chang cells via proteome alterations inducing caspase cascade.

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2007

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Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells

Choi

Terai

et al. 2007

Neoplasia

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We found that beta-lapachone (beta-lap), a novel bioreductive drug, caused rapid apoptosis and clonogenic cell death in A549 human lung epithelial cancer cells in vitro in a dose-dependent manner. The clonogenic cell death caused by beta-lap could be significantly inhibited by dicoumarol, an inhibitor of NAD(P)H:quinone oxido-reductase (NQO1), and also by siRNA for NQO1, demonstrating that NQO1-induced bioreduction of beta-lap is an essential step in beta-lap-induced cell death. Irradiation of A549 cells with 4 Gy caused a long-lasting upregulation of NQO1, thereby increasing NQO1-mediated beta-lap-induced cell deaths. Although the direct cause of beta-lap-induced apoptosis is not yet clear, beta-lap treatment reduced the expression of p53 and NF-kappaB, whereas it increased cytochrome C release, caspase-3 activity, and gammaH2AX foci formation. Importantly, beta-lap treatment immediately after irradiation enhanced radiation-induced cell death, indicating that beta-lap sensitizes cancer cells to radiation, in addition to directly killing some of the cells. The growth of A549 tumors induced in immunocompromised mice could be markedly suppressed by local radiation therapy when followed by beta-lap treatment. This is the first study to demonstrate that combined radiotherapy and beta-lap treatment can have a significant effect on human tumor xenografts.

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Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells

Choi

Terai

et al. 2007

Neoplasia

View full text Add to dashboard Cite

show abstract

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TRAIL-Mediated Apoptosis in Human Liver Chang Cells

Abstract: We suggested that TRAIL induces the apoptotic death of Chang cells via proteome alterations inducing caspase cascade.

Cited by 1 publication

References 0 publications

Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells

Upregulation of NAD(P)H:Quinone Oxidoreductase By Radiation Potentiates the Effect of Bioreductive β-Lapachone on Cancer Cells

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