2009
DOI: 10.2353/ajpath.2009.090099
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TRAIL-Deficient Mice Exhibit Delayed Regression of Retinal Neovascularization

Abstract: While it is well established that tumor necrosis factorrelated apoptosis-inducing ligand (TRAIL) induces apoptosis in various cell types, the role of TRAIL in regulation of retinal neovascularization (NV) has not been described. Here we determined the role of TRAIL in retinal NV during oxygen-induced retinopathy using TRAIL deficient ( ؊/؊ ) mice. TRAIL and its receptor, DR5, were expressed in wild-type retinas at all time points evaluated (postnatal days 12, 17, 21, 24) during oxygen-induced retinopathy and i… Show more

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Cited by 17 publications
(20 citation statements)
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“…Other studies showed that apoptotic bodies derived from neovessel mediate release of cytokines and chemokines that facilitate progenitor cell recruitment, further supporting a role for TNF-␣ in vascular tuft regression (60). Additionally, CCN1 enhances the apoptotic activity of TRAIL and Fas ligand, which has been shown to be involved in endothelial cell death associated with vascular tuft regression (61). Thus, CCN1 induces a selective modulation of TNF-␣ activity that may translate into a more efficient and rapid vascular recovery.…”
Section: Discussionmentioning
confidence: 88%
“…Other studies showed that apoptotic bodies derived from neovessel mediate release of cytokines and chemokines that facilitate progenitor cell recruitment, further supporting a role for TNF-␣ in vascular tuft regression (60). Additionally, CCN1 enhances the apoptotic activity of TRAIL and Fas ligand, which has been shown to be involved in endothelial cell death associated with vascular tuft regression (61). Thus, CCN1 induces a selective modulation of TNF-␣ activity that may translate into a more efficient and rapid vascular recovery.…”
Section: Discussionmentioning
confidence: 88%
“…BCL2L11 expression was responsible for the inherent sensitivity of the developing retinal vasculature to changes in oxygen levels and promoted vessel obliteration in response to hyperoxia [42] . TRAIL (tumor necrosis factor-related apoptosis-inducing ligand), another important proapoptotic factor, is also vital for retinal vasoobliteration and subsequent neovascularization in the mouse OIR model [43] . It has been suggested that no expression of TRAIL in the retina was beneficial for the prevention of retinal neovascularization.…”
Section: Discussionmentioning
confidence: 99%
“…TRAIL expression in the eye is restricted to sites of interaction between key internal ocular structures and the surrounding tissue, much like that for Fas ligand (Griffith et al, 1995; Stuart et al, 1997). TRAIL expression in the retina is also an important regulator of oxygen-induced retinopathy (Hubert et al, 2009). Examination of the placenta, another immune privileged site, found TRAIL expression in syncytiotrophoblasts and Hofbauer cells, as well as a few other placental cell types (Phillips et al, 1999).…”
Section: Immunotherapy Involving Trail Receptor Agonists In Non-camentioning
confidence: 99%